An integrated PCSM model should be implemented systematically and methodologically into future CKD management and health policies.

Aquatic physiotherapy has been shown to be effective in developing balance, strength, and functional reach over time. When dealing with immediate effects, the literature has concentrated more on the body’s physiological response to the physical and mechanical properties of water during passive immersion. The purpose of this study was to evaluate the effects of a single 45-min active aquatic physiotherapy session on standing balance and strength, and its relationship with functional reach in persons 55 years and older with upper limb dysfunction.

The intervention group (

= 12) was assessed before and after a single aquatic physiotherapy session, while the control group (

= 10) was evaluated before and after 45 min of sitting rest. Functional assessment was made using the visual analogue pain scale (points), step test (repetitions), functional reach test (cm), and global balance-standing test on a force platform (% time). A two-way repeated-measures ANOVA was applied (

< 0.05).

The intervention group showed non-significant improvements between measurement before and after the intervention Pain 6.2 ± 1.9 vs. 5.2 ± 2.3 cm, steps 7.0 ± 2.0 vs. 7.4 ± 1.8 repetitions, reach 9.1 ± 2.8 vs. 10.4 ± 3.8 cm, and balance 61.7 ± 5.9 vs. 71.3 ± 18.2% time in balance on the platform. The control group showed fewer changes but had better baseline values. A comparison between groups with time showed no significant differences in these changes.

No significant immediate effects were found for one session of aquatic physiotherapy applied to patients older than 55 years with upper limb dysfunction.

No significant immediate effects were found for one session of aquatic physiotherapy applied to patients older than 55 years with upper limb dysfunction.Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted from the gut upon nutrient stimulation and regulate postprandial metabolism. These hormones are known as classical incretin hormones and are responsible for a major part of postprandial insulin release. The incretin effect is severely reduced in patients with type 2 diabetes, but it was discovered that administration of GLP-1 agonists was capable of normalizing glucose control in these patients. Over the last decades, much research has been focused on the development of incretin-based therapies for type 2 diabetes. These therapies include incretin receptor agonists and inhibitors of the incretin-degrading enzyme dipeptidyl peptidase-4. Especially the development of diverse GLP-1 receptor agonists has shown immense success, whereas studies of GIP monotherapy in patients with type 2 diabetes have consistently been disappointing. Interestingly, both GIP-GLP-1 co-agonists and GIP receptor antagonists administered in combination with GLP-1R agonists appear to be efficient with respect to both weight loss and control of diabetes, although the molecular mechanisms behind these effects remain unknown. This review describes our current knowledge of the two incretin hormones and the development of incretin-based therapies for treatment of type 2 diabetes.For the efficient and durable design of concrete, the role of fiber-reinforcements with mineral admixtures needs to be properly investigated considering various factors such as contents of fibers and potential supplementary cementitious material. Interactive effects of fibers and mineral admixtures are also needed to be appropriately studied. In this paper, properties of concrete were investigated with individual and combined incorporation of steel fiber (SF) and micro-silica (MS). SF was used at six different levels i.e., low fiber volume (0.05% and 0.1%), medium fiber volume (0.25% and 0.5%) and high fiber volume (1% and 2%). Each volume fraction of SF was investigated with 0%, 5% and 10% MS as by volume of binder. All concrete mixtures were assessed based on the results of important mechanical and permeability tests. The results revealed that varying fiber dosage showed mixed effects on the compressive (compressive strength and elastic modulus) and permeability (water absorption and chloride ion penetration) properties of concrete. Generally, low to medium volume fractions of fibers were useful in advancing the compressive strength and elastic modulus of concrete, whereas high fiber fractions showed detrimental effects on compressive strength and permeability resistance. The addition of MS with SF is not only beneficial to boost the strength properties, but it also improves the interaction between fibers and binder matrix. MS minimizes the negative effects of high fiber doses on the properties of concrete.Distribution patterns of the European fruit lecanium Parthenolecanium corni (Bouché) and of grapevine leafroll-associated virus-1 (GLRaV-1) and grapevine virus A (GVA) were monitored from 2003 to 2015 in a Riesling vine plot in the northeast of France. Virus spread was compared between two periods 2003-2008 and 2009-2014. The percentage of infected vines increased from 54 to 78% for GLRaV-1 and from 14 to 26% for GVA. The spatial distribution of viruses and of P. corni was analysed using permutation tests and revealed an aggregative pattern. Virus distribution was not associated with the density of P. corni population on grapevines. However, GLRaV-1 and GVA spread mainly from initially infected vines. New GLRaV-1 and GVA infections were more frequent on vines near primarily infected vines, first anisotropically along the row, then between neighbouring rows. Virus spread was similar to those described in literature with grapevine mealybug species. This slow vine-to-vine progression suggests that P. corni was responsible for the virus spread, in accordance with the low mobility and low transmission capacities of its local population.Smart cities are complex, socio-technological systems built as a strongly connected System of Systems, whose functioning is driven by human-machine interactions and whose ultimate goals are the well-being of their inhabitants. Consequently, controlling a smart city is an objective that may be achieved by using a specific framework that integrates algorithmic control, intelligent control, cognitive control and especially human reasoning and communication. Among the many functions of a smart city, intelligent transportation is one of the most important, with specific restrictions and a high level of dynamics. This paper focuses on the application of a neuro-inspired control framework for urban traffic as a component of a complex system. It is a proof of concept for a systemic integrative approach to the global problem of smart city management and integrates a previously designed urban traffic control architecture (for the city of Bucharest) with the actual purpose of ensuring its proactivity by means of traffic flow prediction. Analyses of requirements and methods for prediction are performed in order to determine the best way for fulfilling the perception function of the architecture with respect to the traffic control problem definition. A parametric method and an AI-based method are discussed in order to predict the traffic flow, both in the short and long term, based on real data. A brief comparative analysis of the prediction performances is also presented.The vibration of the periodic oscillator coupled damping beam model is reduced through the band gaps designing method, which can be applied in equivalent engineering structures. In this paper, the flexural wave dispersion relations of the infinite long periodic oscillator coupled damping beam were calculated using the reverberation-ray matrix method combined with the Bloch theorem. The flexural wave vibration frequency response function of the finite long periodic oscillator coupled damping beam was carried out using the finite element method. The flexural wave vibration band gaps occur in the infinite long periodic oscillator coupled damping beam model in both the analytical and numerical results. In these band gaps, flexural waves’ propagation is prohibited, and flexural vibration is significantly suppressed. Furthermore, the effects of structure and material parameters on the flexural wave vibration band gaps characteristics are studied. Thus, the structural vibration reduction design can be realized by adjusting the related parameters of the periodic coupled damping beam structures and the equivalent 2D periodic stiffened plate structures.This study aimed to identify determinants of quantitative dimensions of physical activity (PA; duration, frequency, and intensity) in community-dwelling, multi-morbid, older persons with cognitive impairment (CI). In addition, qualitative and quantitative aspects of habitual PA have been described. Quantitative PA and qualitative gait characteristics while walking straight and while walking turns were documented by a validated, sensor-based activity monitor. Univariate and multiple linear regression analyses were performed to delineate associations of quantitative PA dimensions with qualitative characteristics of gait performance and further potential influencing factors (motor capacity measures, demographic, and health-related parameters). In 94 multi-morbid, older adults (82.3 ± 5.9 years) with CI (Mini-Mental State Examination score 23.3 ± 2.4), analyses of quantitative and qualitative PA documented highly inactive behavior (89.6% inactivity) and a high incidence of gait deficits, respectively. The multiple regression models (adjusted R2 = 0.395-0.679, all p less then 0.001) identified specific qualitative gait characteristics as independent determinants for all quantitative PA dimensions, whereas motor capacity was an independent determinant only for the PA dimension duration. Demographic and health-related parameters were not identified as independent determinants. High associations between innovative, qualitative, and established, quantitative PA performances may suggest gait quality as a potential target to increase quantity of PA in multi-morbid, older persons.The induction of protein degradation in a highly selective and efficient way by means of druggable molecules is known as targeted protein degradation (TPD). TPD emerged in the literature as a revolutionary idea a heterobifunctional chimera with the capacity of creating an interaction between a protein of interest (POI) and a E3 ubiquitin ligase will induce a process of events in the POI, including ubiquitination, targeting to the proteasome, proteolysis and functional silencing, acting as a sort of degradative knockdown. With this programmed protein degradation, toxic and disease-causing proteins could be depleted from cells with potentially effective low drug doses. The proof-of-principle validation of this hypothesis in many studies has made the TPD strategy become a new attractive paradigm for the development of therapies for the treatment of multiple unmet diseases. Indeed, since the initial protacs (Proteolysis targeting chimeras) were posited in the 2000s, the TPD field has expanded extraordinarily, developing innovative chemistry and exploiting multiple degradation approaches. In this article, we review the breakthroughs and recent novel concepts in this highly active discipline.