CI provides important auditory and QOL benefits in AHL, but there is no high level evidence as yet to strongly support CI for AHL. A long term multi-centric study is necessary to influence a change in practice for a growing population of AHL.

ClinicalTrials.gov identifier NCT03052920.

CI provides important auditory and QOL benefits in AHL, but there is no high level evidence as yet to strongly support CI for AHL. A long term multi-centric study is necessary to influence a change in practice for a growing population of AHL.Trial registration ClinicalTrials.gov identifier NCT03052920.Objectives. A cohort study was designed and implemented to determine the prevalence of hearing problems and their related factors in professional drivers in Shahroud city. Methods. In total, 1461 professional drivers were examined. Demographic information, work history, blood parameters, and anthropometric and audiometric test data were collected. Hearing thresholds were assessed at frequencies of 500, 1000, 2000, 3000, 4000, 6000 and 8000 Hz. Results. In total, 64.8% and 54.9% of hearing impairment degrees were observed in the left and right ears, respectively, and this difference was statistically significant. The hearing threshold in the left ear was higher at all frequencies. The maximum hearing loss was at 6000 Hz, followed by 4000 Hz. There was a significant relationship between hearing loss with age groups for right and left ears and type of car for left ear. Conclusion. The prevalence and severity of hearing loss in Shahroud drivers are high, and most hearing loss is observed in the left ear. Given that noise-induced hearing loss is an incurable condition and has a significant impact on individuals’ quality of life and employment, drivers should be regularly screened for ear damage under the variables affecting hearing loss, and noise prevention training should be provided.Accurately determining a change in protein binding affinity upon mutations is important to find novel therapeutics and to assist mutagenesis studies. Determination of change in binding affinity upon mutations requires sophisticated, expensive, and time-consuming wet-lab experiments that can be supported with computational methods. Most of the available computational prediction techniques depend upon protein structures that bound their applicability to only protein complexes with recognized 3D structures. In this work, we explore the sequence-based prediction of change in protein binding affinity upon mutation and question the effectiveness of [Formula see text]-fold cross-validation (CV) across mutations adopted in previous studies to assess the generalization ability of such predictors with no known mutation during training. We have used protein sequence information instead of protein structures along with machine learning techniques to accurately predict the change in protein binding affinity upon mutation. Our proposed sequence-based novel change in protein binding affinity predictor called PANDA performs comparably to the existing methods gauged through an appropriate CV scheme and an external independent test dataset. On an external test dataset, our proposed method gives a maximum Pearson correlation coefficient of 0.52 in comparison to the state-of-the-art existing protein structure-based method called MutaBind which gives a maximum Pearson correlation coefficient of 0.59. Our proposed protein sequence-based method, to predict a change in binding affinity upon mutations, has wide applicability and comparable performance in comparison to existing protein structure-based methods. We made PANDA easily accessible through a cloud-based webserver and python code available at https//sites.google.com/view/wajidarshad/software and https//github.com/wajidarshad/panda, respectively.Mephentermine is a sympathomimetic amine, frequently used as a vasopressor. It is structurally comparable to amphetamines, and World Anti-Doping Agency has prohibited its use as a performance-enhancing drug. However, its illegal consumption by several sportspersons and those appearing for physical endurance tests is a growing concern for health-care professionals. We present a case of misuse of intravenous mephentermine by a young male who abruptly increased its amount a few days prior to the sports competition and developed acute psychosis. The case report highlights the need for strict regulations for procuring methamphetamine and effective treatment strategies for managing its misuse.The main goal of this study was to identify whether changes and new applications were positively or negatively influencing safety performance among health-sector workers. The research is based on the opinion of 16 selected occupational health and safety (OHS) experts who evaluated five main groups of questions by the analytic hierarchy process (AHP). The results were compared to the same questionnaire’s results applied previously at three main hospitals in Bingöl, Turkey. The results presented are predictable, such as that of private hospitals having better control and pressure on applying the OHS system; experts gave higher priority to OHS training; and staff considered that working according to OHS criteria was the most important problem. Caring about others’ safety and protecting one’s own life, being knowledgeable about risks, having practical OHS training and cooperation are other important criteria according to the experts.There is a significant need in the current industrial scenario for methods to be formulated to treat dangerous chemicals most safely. Accidental release of toxic chemicals will result in emergencies. Hence, an emergency response plan (ERP) is inevitable. The most toxic chemicals in the water and wastewater sector are chlorine and hydrogen sulphide, whereas methane is a flammable gas. CAMEO software is used in this research to predict the region that toxic gas release impacts. This research deals with a sewage treatment plant ERP and control measures for methane and chlorine gases. The affected area of hazard will depend upon the weather conditions and the time of the accident. Comparing two different seasons, the impacted distance is more significant in summer than in winter. It is observed that the night and early morning is more dangerous than the afternoon and evening as it shows the larger impacted distance.In a 2015-2016 UK survey of 35, 248 adults, 7% reported experiencing sexual abuse as children. This review considers the value of Art Therapy (AT) in recognizing individual needs and experiences and supporting victims to manage the lasting impact of abuse. Three main bodies of research were identified the use of AT in childhood sexual abuse (CSA) investigations; the use of art therapy in the treatment of the psychological sequelae of CSA victims in childhood and adulthood; and an assessment of how art therapy compares to other therapeutic approaches for CSA victims. The review highlights that AT particularly benefits rapport building between victim and therapist/investigator, and alleviates some psychological consequences of sexual abuse – particularly anxiety, post-traumatic stress, and dissociation. By engaging the limbic system, AT may also provide a communicative form, building a narrative where verbal communication is hindered. However, the analysis brings attention to several weaknesses in the current AT research available studies tend to have small sample sizes and few quantitative findings. This review concludes by identifying the need for research which considers the clinical implications of AT in CSA cases for the future.Purpose In developing countries, health and safety is not given importance especially in small and medium sized enterprises. Incidences of health and safety are continuously increasing. Major reason is lack of work place safety culture. Secondly, enterprises lack resources, therefore, it becomes hard for them to provide safety climate. Along with safety climate and safety culture behavior of leadership play a significant role towards safety performance. Therefore, the purpose of this study is to analyze the moderating role of leadership for gaining safety performance through safety culture and safety climate.Materials and Methods For the said purpose the authors collected data from the labors and managers. A structured questionnaire was adopted and after ensuring the reliability structural equation modeling was applied.Results and Conclusions The findings revealed that safety culture and safety climate both have a significant impact over safety performance, however, transformational leadership only moderates the relationship between safety culture and safety performance. The identification of moderating role of transformational leadership is a significant contribution in the social cognitive theory. Future researchers are also guided to identify the same link over large industries of developing countries.Intravenous thrombolysis elevates the prognostic level of acute ischemic stroke (AIS) patients. Normobaric hyperoxia (NBO) delays the progression of the infarct core and promotes neurological recovery. However, it is uncertain whether NBO can further raise the prognostic level of AIS patients based on intravenous thrombolysis. To explore the efficacy and safety of NBO combined with intravenous thrombolysis on AIS patients. This observational study included anterior circulation stroke patients who received intravenous thrombolysis within 4.5 h after stroke onset. These patients were divided into two groups based on whether or not they received NBO therapy. The baseline data and the prognosis of the two groups were compared. The primary outcome was the proportion of functional independence (modified Rankin Scale 0-2) at 90 days post discharge. A total of 227 patients were included in this study. 125 patients received NBO therapy combined with intravenous thrombolysis, while 102 patients received intravenous thrombolysis only. Overall, the rate of recanalization was 83.3%. Consequently, 101 patients (80.8%) who received NBO combined with intravenous thrombolysis and 63 patients (61.8%) in the control group achieved functional independence (P = 0.002). Multivariable logistic regression analysis showed that NBO combined with intravenous thrombolysis over intravenous thrombolysis alone was associated with 90-day functional independence (OR 2.318; 95% CI 1.226-4.381; P = 0.01). This study verified the efficacy and safety of NBO combined with intravenous thrombolysis in AIS patients. Prospective study is needed to further substantiate these findings.Objectives. Lean construction techniques have been considered an effective approach and strategy to reduce accidents in construction projects. This article aims to investigate the application of the lean construction principle and its impact on occupational health and safety. Methods. To achieve the aim, an analytical descriptive method was used. The data were collected through a questionnaire, with 70 respondents who were chosen using a random stratified sample method. The questionnaire evaluated the perception of contractors and consultants about the important lean construction factors and their impact on construction project safety. Results. There is an agreement that the application of lean construction techniques can be impeded by challenges like lack of lean construction knowledge, complexity, misconception about lean construction and difficulties in changing employees. Conclusions. The study identified strategies that could be used to address these challenges that will improve the safety of construction projects.