Because of significant changes in recent years, cases of illicit drug exposure reported to the Poisons Information Centre (PIC) Erfurt during the last 10 years were investigated.

Retrospective analysis of above-mentioned cases from 2011 to 2020 according to substance classes, symptom severity, age groups, and gender.

Cases of illicit drug exposure (4,963, 2.8% of all exposures) increased from 316 in 2011 to 614 in 2015, decreased to 514 in 2017, and rose again to 578 in 2019. In 2020, a drop to 549 cases was observed. The ratio of multiple to single drug exposure cases, however, increased from 1.0 to 1.7 in 2020. Cases of exposure to psychostimulants almost doubled from 168 in 2011 to 319 in 2020. Cases of exposure to new psychoactive substances (NPS) rose from 21 in 2011 to 126 in 2015 and fell to 16 in 2020. 320 cases (6.5%) of illicit drug exposures resulted in severe, 1902 cases (38.3%) in moderate and 2139 cases (43.1%) in minor or no symptoms. Age groups mainly involved were adults of middle age (72.7%) and unknown age (12.7%) as well as adolescents (12.1%). Men (69.9%) were more often involved than women (26.9%).

Illicit drug exposures reported to the Poisons Information Centre (PIC) Erfurt discontinuously increased from 2011 to 2020 mainly by increase in mixed consumption. The intermittent decrease in 2016 and 2017 was caused by the fall of NPS exposures. Data of substance abuse from PICs could supplement official annual drug reports in aspects of Clinical Toxicology.

Illicit drug exposures reported to the Poisons Information Centre (PIC) Erfurt discontinuously increased from 2011 to 2020 mainly by increase in mixed consumption. The intermittent decrease in 2016 and 2017 was caused by the fall of NPS exposures. Data of substance abuse from PICs could supplement official annual drug reports in aspects of Clinical Toxicology.

 Vasospasm is a major problem following microsurgical reconstruction which can result in the partial or complete loss of the flap tissue. The aim of this study was to investigate the efficiency of hydrodilatation for the prevention of vasospasm.

 Thirty male Wistar rats were used for this experimental study. Femoral arteries of were exposed, photographed, and transected. In group 1, group 2, and group 3 papaverine solution, hydrodilatation, and minimal mechanical dilatation (control group) was performed, respectively. The anastomosis was completed and the arteries were photographed again 10 minutes after completion of the anastomosis. Following 7-day period samples for transmission electron microscopy (TEM) and light microscopy were obtained.

 The mean vessel diameters prior to transection were 0.43, 0.45, and 0.52 mm in the papaverine, hydrodilatation, and control groups, respectively. The mean vessel diameter 10 minutes following the completion of anastomosis was 0.76, 0.75, and 0.51 mm in the papavergroup showed a vasodilatory effect that was statistically similar to that of papaverine, which has a proven efficacy.

 Hydrodilatation and papaverine application were both effective in preventing vasospasm following microsurgical intervention but papaverine caused slightly less damage to the endothelial lining and less edema in the tunica adventitia when compared with the hydrodilatation. Hydrodilatation group showed a vasodilatory effect that was statistically similar to that of papaverine, which has a proven efficacy.Autonomic disorders are common in patients with SLE, but the therapeutic strategy and methods for evaluating the effects of therapy have not been established. We describe the three cases of SLE patients who developed severe autonomic disorders as demonstrated by the head-up tilt table test (HUT). All three patients were treated by intensive immunosuppressive treatments including cyclophosphamide (IVCY); their HUT results all became negative. Our cases suggest that IVCY treatment can be a good therapeutic option for severe autonomic disorders in SLE patients. The HUT is a useful objective method for the diagnosis of and the evaluation of longitudinal therapeutic effects on autonomic disorders in SLE patients with orthostatic intolerance.Residual expressions of enteric emissions favour a more equitable identification of an animals methanogenic potential compared to traditional measures of enteric emissions. The objective of this study was to investigate the effect of divergently ranking beef cattle for residual methane emissions (RME) on animal productivity, enteric emissions and rumen fermentation. Dry matter intake (DMI), growth, feed efficiency, carcass output and enteric emissions (Greenfeed emissions monitoring system) was recorded on 294 crossbred beef cattle ((steers = 135 and heifers = 159; mean age 441 days (SD = 49); initial body weight (BW) of 476 kg (SD = 67)) at the Irish national beef cattle performance test centre. Animals were offered a total mixed ration (77% concentrate and 23% forage; 12.6 MJ ME/kg of DM and 12% CP) ad libitum with emissions estimated for 21 days over a mean feed intake measurement period of 91 days. Animals had a mean daily methane emissions (DME) of 229.18 g/d (SD = 45.96), methane yield (MY) of 22.07 g/khane traits. Greater acetatepropionate ratio was associated with higher RME (r=0.18; P less then 0.05). Under the ad libitum feeding regime deployed here, RME was the best predictor of DME and only methane trait independent of animal productivity. Ranking animals on RME presents the opportunity to exploit inter animal variation in enteric emissions as well as providing a more equitable index of the methanogenic potential of an animal on which to investigate the underlying biological regulatory mechanisms.This conference was convened by the Chiropractic Educators Research Forum (CERF) on June 26, 2021. This meeting provided a forum for the presentation of scholarly works in education theory and practice. The conference specifically focused on research related to education and learning assessment. During the June 2021 CERF meeting, presenters and panelists took an in depth look at how programs assess learning, including both summative and formative assessments, either live or asynchronously through technology or the internet.It is hypothesized that heat processing may increase P digestibility in different protein sources fed to growing pigs. A study was conducted to determine the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of P in soybean expeller (SBE) produced from oil extraction using dry extrusion and expelling and to investigate the effects of heat treatment on the ATTD and STTD of P in SBE, canola meal (CM), and canola expeller (CE) fed to growing pigs. Thirty-six growing barrows with an initial body weight of 19.0 ± 1.0 kg (mean ± SD) were assigned to 1 of 6 experimental diets in a completely randomized design to give 6 replicates per diet. The experimental design was a 3 × 2 factorial arrangement including three oilseed meals with or without heat treatment. The diets were formulated to contain non-autoclaved or autoclaved (at 121 °C for 60 min) SBE, CM, and CE as the sole source of P. Limestone was included in diets to maintain a Catotal P ratio of 1.31 across diets. Pigs were individually housed in metabolism crates for 12 d, including 7 d for adaptation and 5 d for total collection of feces. Pigs were offered their daily ration at 2.8 times their maintenance energy requirement. Data were analyzed using the PROC MIXED of SAS. Heat treatment increased (P less then 0.05) the ATTD and STTD of P. Pigs fed the SBE diets had greater (P less then 0.05) ATTD and STTD of P than pigs fed CM and CE diets. For the autoclaved ingredients, the values of STTD of P were 49.4%, 23.2%, and 25.8% for SBE, CM, and CE, respectively, whereas STTD of P in non-autoclaved SBE, CM, and CE were 48.5%, 20.2%, and 22.5%. Heat treatment increased (P less then 0.05) the ATTD of Ca. In conclusion, heat treatment increased ATTD and STTD of P and ATTD of Ca in SBE, CM, and CE fed to growing pigs. The ATTD and STTD of P in SBE determined in the current study were 41.0% and 48.5%, respectively.A few-cycle mid-infrared (MIR) laser is demonstrated via nonlinear self-compression in solid thin plates. In this novel solution, the anomalous material dispersion in the MIR band and the chirp induced by self-phase modulation are mutually compensated, which can achieve self-compression. Finally, with the 4 µm laser injection with 4.8 mJ/155 fs and few-cycle pulses with 3.44 mJ, 29.4 fs are generated with a high efficiency of 71.7%, and the system maintains very good spectral stability in 10 days. Compared with other post-compression methods, this self-compression technique has the advantages of high efficiency and robust and large energy expansion scale, which can be further extended to MIR lasers with other wavelengths and higher peak power.Photoacoustic imaging of elastomers has important biomedical value. However, a bright background, e.g., blood vessels in living tissue, brings a challenge for photoacoustic elastography. In this study, we predicted that the spectrum of photoacoustic signals from elastomers with high elasticity could appear as narrow peaks at the eigen-frequencies of elastomers, but the signals from a bright background, e.g., blood vessel, show flat broadband spectrum for their low-quality factor. Even when the two kinds of signals are mixed together, the signals from elastomers can be identified from the spectrum since they present as convex narrow peaks on a wide base. Based on this factor, we propose a multispectral photoacoustic holography to realize selective imaging of tiny elastomers. This method recovers the image only using several frequency components in photoacoustic signals, instead of the whole-band signal. Since these narrow peaks in the spectrum correspond to the eigen-vibration of elastomers, the proposed method can highlight the elastomers with high elasticity from a bright background with low elasticity. The method was validated by experiments. This study might be helpful to localize elastic anomalous areas in the tissue, such as calcification in the vascular network, microcalcification in a tumor, and implants.To date, various studies have been dedicated to the development of cholesteric liquid crystal (CLC) microdroplet omnidirectional lasers. In this work, a stable and tunable multi-mode laser emission is achieved by designing a dye-doping CLC microdroplet. In such a structure, the polymer network only exists on the surface, maintaining stability while providing tunability, and due to the uneven distribution of the pitch, it leads to multi-mode laser emission. A large number of microdroplets are produced quickly via a new method based on ultrasonic separation. During the reaction, we introduce interfacial polymerization where monomers and photoinitiator are respectively distributed inside and outside the microdroplets through mutual diffusion, which enables one to make the polymer network exist on the surface instead of the interior. The obtained microdroplet-based multi-mode laser is shown to possess stability and tunability, demonstrating a great potential for flexible devices and 3D displays.