on predicted CYP2D6 phenotypes in AMR-EUR and AMR-NAT, but affects prediction in 10.7 and 21.6% of BR-EUR and BR-AFR individuals, respectively. CONCLUSION Collectively, the present results reveal potential pharmacogenomic (PGx) implications of the population diversity in Latin America, affecting a major drug-metabolizing pathway. selleckchem Thus, the influence of enhancer rs5758550 on assignment of CYP2D6 metabolic phenotypes varies markedly, according to the individual proportions of Native, European and African ancestry. This conclusion reinforces the notion that extrapolation of PGx data across the heterogeneous Latin American is risky, if not inappropriate.BACKGROUND AND OBJECTIVES Pharmacogenomics (PGx) is the use of human genomic information to avoid toxicity and optimize efficacy of drug therapy in an individual. Hospital pharmacists are the key persons to facilitate the incorporation of PGx into clinical practice. PGx is relatively new to Thai hospital pharmacists. Therefore, this study aimed to evaluate the knowledge, attitude, and practice of Thai hospital pharmacists towards PGx implementation. MATERIALS AND METHODS We conducted a cross-sectional questionnaire-based survey among 600 hospital pharmacists in 21 hospitals across Thailand. The questionnaire consisted of 35 questions using comment boxes, Likert scales, and multiple choice answers. RESULTS The response rate was 20.5% (n = 123). link2 Nearly half of the hospital pharmacists (46.3%) had low PGx knowledge score ( less then 5 points), particularly for applied PGx knowledge in clinical situations. Concerns regarding PGx reimbursement, privacy issues, and discrimination were mentioned in this survey. However, most hospital pharmacists had positive attitude towards PGx service. Only 7% of hospital pharmacists had recommended or interpreted PGx tests in the past year. National PGx guidelines and government policies were considered the important factors for PGx implementation. Moreover, the most preferred learning format for PGx education was professional academic conferences. CONCLUSION Hospital pharmacists in Thailand had positive attitude towards PGx, despite limited experience and practice of PGx. link3 PGx education to support an application of PGx knowledge in clinical situations is required. National PGx guidelines and government policies may need to be developed to address the concerns for reimbursement, privacy, and discrimination to ensure successful PGx implementation.Ferrari, L, Colosio, AL, Teso, M, and Pogliaghi, S. Performance and anthropometrics of classic powerlifters which characteristics matter? J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study is (a) provide normative performance and anthropometric data of Southern European classic powerlifters of both sexes; (b) determine the possible relationships between these variables and performance; and (c) develop population-specific predictive equations for single lifts and overall powerlifting performance. During an unofficial national-level competition, we recruited 74 athletes (51 men and 23 women) and recorded their individual, anthropometric, and performance characteristics and divided them into sex and 2 performance categories based on their Wilks points. Weaker (370 Wilks points) athletes of both sexes were compared by two-way analysis of variance. Simple correlation and multiple linear regression between individual/anthropometric characteristics and performance were modeled. We applied a step-forward multiple linear regression model to predict single lifts and overall performance. All parameters significantly differed between sexes (p less then 0.05 for all comparisons). Stronger male athletes had a significantly larger neck (42 ± 2.8 cm; effect size [ES] = 0.59), and flexed (40.6 ± 3.3 cm; ES = 1.18) and relaxed upper-arm (37.5 ± 3.1 cm; ES = 1.34) and thigh girths (63.6 ± 7.0 cm; ES = 0.77) compared to weaker male athletes. Furthermore, stronger women had significantly larger flexed (32.6 ± 3.3 cm; ES = 0.88) and relaxed upper-arm (33 ± 1.5 cm; ES = 2.28) and chest girths (99.3 ± 9.2 cm; ES = 1.10) compared to weaker female athletes. A combination of experience, fat mass, and upper-limb and lower-limb muscle mass indexes can accurately and precisely predict overall and individual lift performance (r ≥ 0.83 for all the predictions). This is the first study to provide normative performance and anthropometric data in Southern European male and female powerlifters.Schoenmakers, PPJM, Crisell, JJ, and Reed, KE. Physiological and perceptual demands of running on a curved nonmotorized treadmill compared with running on a motorized treadmill set at different grades. J Strength Cond Res XX(X) 000-000, 2020-The current study compared the physiological and perceptual demands of running on a commercially available curved nonmotorized treadmill (cNMT) with different incline grades on a motorized treadmill (MT). Ten male team-sport athletes completed, after a familiarization session, a 6-minute run at a target velocity of 2.78 m·s on the cNMT (cNMTrun). The mean individual running velocity of cNMTrun was then used as warm-up and experimental running velocity in 3 subsequent visits, in which subjects ran for 6 minutes on the MT set at different grades (4, 6, or 8%). In all experimental trials (cNMTrun, 4MTrun, 6MTrun, and 8MTrun) and in the warm-up of the subjects’ third visit (1MTrun), oxygen consumption (V[Combining Dot Above]O2) and heart rate (HR) were monitored, and ratings of perceived exertion (RPE) were obtained. The HR in cNMTrun was significantly higher compared with all MT trials. V[Combining Dot Above]O2 and RPE were significantly higher in cNMTrun compared with 1MTrun and 4MTrun, but not different from 6MTrun and 8MTrun. The relationship between V[Combining Dot Above]O2 and MT grades was highly linear (V[Combining Dot Above]O2 = 34.36 + 1.7 MT grade; r = 0.99), and using linear interpolation, the concave curved design of the cNMT was estimated to mimic a 6.9 ± 3% MT grade. On matched running velocities, V[Combining Dot Above]O2 and RPE responses while running on the cNMT are similar to a 6-8% MT grade. These findings can be used as a reference value by athletes and coaches in the planning of cNMT training sessions and amend running velocities accordingly. Future studies are needed to determine whether this estimate is similar for female runners, or those of a lower body mass.Haycraft, JAZ, Kovalchik, S, Pyne, DB, and Robertson, S. Classification of players across the Australian Rules football participation pathway based on physical characteristics. J Strength Cond Res XX(X) 000-000, 2020-This study investigated the utility of physical fitness and movement ability tests to differentiate and classify players into Australian Football League (AFL) participation pathway levels. Players (n = 293, age 10.9-19.1 years) completed the following tests; 5-m, 10-m, and 20-m sprint, AFL planned agility, vertical jump (VJ), running VJ, 20-m multistage fitness test (MSFT), and athletic ability assessment. A multivariate analysis of variance between AFL participation pathway levels was conducted, and a classification tree determined the extent to which players could be allocated to relevant levels. The magnitude of differences between physical fitness and movement ability were level-dependent, with the largest standardized effect size (ES) between Local U12, Local U14, and older levels for most physical fitness tests (ES -4.64 to 5.02), except the 5-m and 10-m sprint. The 20-m, 5-m, AFL agility, 20-m MSFT, overhead squat, and running VJ (right) contributed to the classification model, with 57% overall accuracy reported (43% under cross-validation). National U16 players were easiest to classify (87%), while National U18 players were most difficult (0%). Physical fitness tests do not seem to differentiate between players after selection into AFL talent pathway levels. Other attributes (i.e., skill, psychological, and sociocultural) should be prioritized over physical fitness and movement attributes by selectors/coaches when considering selection of talented players.Marcel-Millet, P, Ravier, G, and Groslambert, A. Effect of protective equipment on firefighters’ external and internal workloads during a simulated rescue intervention. J Strength Cond Res XX(X) 000-000, 2020-Firefighter’s protective equipment is one of the main factors increasing psychophysiological demand during rescue intervention. Workload quantification defines the amount of stress placed on an individual. This study aimed to test the relationships and compare different workload methods to discriminate 3 protective equipment conditions based on simulated rescue intervention. The protective equipment was (a) personal protective clothing (PPC); (b) PPC and a self-contained breathing apparatus (SCBA), including a cylinder, a full-face piece, and a breathing regulator; and (c) PPC and only the cylinder of the SCBA (SCBAc). Workload was determined using methods based on heart rate (HR), perceived exertion (sRPE), acceleration, and an indirect method based on postexercise HR variability. Differences between cod SCBA conditions.Ramírez-Vélez, R, Castro-Astudillo, K, Correa-Bautista, JE, González-Ruíz, K, Izquierdo, M, García-Hermoso, A, Álvarez, C, Ramírez-Campillo, R, and Correa-Rodríguez, M. The effect of 12 weeks of different exercise training modalities or nutritional guidance on cardiometabolic risk factors, vascular parameters and physical fitness in overweight adults cardiometabolic high-intensity interval training-resistance training randomized controlled study. J Strength Cond Res XX(X) 000-000, 2020-Evidence suggests that exercise training improves cardiometabolic risk factors. The aim of this study was to investigate whether 12 weeks of high-intensity interval training (HIIT), resistance training (RT), concurrent training (CT = HIIT + RT), or nutritional guidance (NG) induced improvements in cardiometabolic risk factors, vascular parameters, and physical fitness in overweight adults, and to compare the responses between the 4 intervention groups. Twelve-weeks factorial randomized design examining the effects of different T group has a significant positive impact on the FMD (%) in comparison to HIIT, CT, or NG group (time × group interaction F(2.942); p = 0.044; η partial = 0.174). The main findings of this study are that 12 weeks of HIIT leads to significant improvements in cardiorespiratory fitness, whereas RT resulted in improvements in the vascular profile, supporting the positive effect of both training programs for cardiometabolic risk factors in sedentary and overweight adults.Gil, MH, Neiva, HP, Alves, AR, Sousa, AC, Ferraz, R, Marques, MC, and Marinho, DA. The effect of warm-up running technique on sprint performance. J Strength Cond Res XX(X) 000-000, 2020-The purpose of the current study was to analyze the effect of changing the running technique during warm-up on sprint performances, running biomechanics, physiological, and psychophysiological responses. Thirty-one physically active men aged 18-23 years (mean ± SD 19.35 ± 1.08 years of age; 1.77 ± 0.07 m of height; 71.90 ± 10.37 kg of body mass) volunteered to participate and randomly performed 2 maximal 30-m sprints, 5 minutes after completing a warm-up focused on increased stride length-SL (WUL) or a warm-up focused on increased stride frequency-SF (WUF). The results showed that there were no differences between the 30-m sprint performances and in running biomechanics. However, WUF showed increased performances in the first 15 m of the race (WUF 2.59 ± 0.11 seconds vs. WUL 2.63 ± 0.15 seconds; p = 0.03), and WUL resulted in higher performances in the last 15 m (1.