2 at 723 K in AgSb0.94Pb0.06Se2. This study opens a new avenue for rapid, low-cost, large-scale production of AgSbSe2-based materials and demonstrates that Pb-doped AgSbSe2 prepared via the SHS-SPS method is a promising candidate for thermoelectric applications.We introduce cracked film lithography (CFL) as a way to reduce the cost of III-V photovoltaics (PV). We spin-coat nanoparticle suspensions onto GaAs thin-film device stacks. The suspensions dry in seconds, forming crack networks that we use as templates through which to electroplate the solar cells’ front metal grids. For the first time, we show that heating the crack template allows it to flow and refill cracks, which decreases crack footprint and improves final grid transmittance. We demonstrate 24.7%-efficient single-junction GaAs solar cells using vacuum-free CFL grids. These devices are only 1.7% (absolute) less efficient than the baseline grids patterned by photolithography with the loss mostly resulting from the reduced transparency of the CFL pattern. Additional optimization could decrease this difference. Initial cost modeling suggests that CFL is more scalable than photolithography In particular, CFL’s lower materials and equipment costs could greatly reduce the levelized cost of electricity of III-V PV at scale, a potential step toward terrestrial deployment.Four tris-bidentate catecholamide (CAM) ligands were synthesized, characterized, and evaluated as ligands for radiolabeling of gallium-68 for positron emission tomography (PET). Three of those ligands, 2,2-Glu-CAM, 3,3-Glu-CAM, and TREN-bisGlyGlu-CAM, incorporate ligand caps that contain a pendant carboxylic group for further conjugation to targeting moieties. The acyclic ligands all exhibited high (>80%) radiolabeling yields after short reaction times (95%) render TREN-bisGlyGlu-CAM a promising candidate for gallium-68 chelation.We report on a heterogeneous dendrimer (G3-acetal-NH2) derivative possessing an acid-responsive charge-reversal layer. The synthesis of G3-acetal-NH2 starts with a polyamidoamine (PAMAM) dendrimer G3 core and follows the aza-Michael addition with N-(2-(1-(allyloxy)ethoxy)ethyl)acrylamide synthesized by us and the thiol-ene click chemistry with cysteamine hydrochloride in sequence. In a weakly acidic environment, the surface of this newly formed dendrimer can turn from amine-terminated to hydroxyl-terminated due to the cleavage of the acetal groups. This charge conversion from 34.3 ± 2.7 to 18.0 ± 0.3 mV in 24 h at pH 5.3 enables its capacity as a gene delivery vehicle. G3-acetal-NH2 with a positively charged surface can condense pMAX GFP plasmid at similar weight ratios as native G4-NH2 (above 21), allowing for its protected uptake into cells and endosomal escape. Meanwhile, in the endosome, the drop in vesicle pH cleaves the acetal bond, releasing the genetic payload and limiting its recondensation by the reduction in the dendrimer surface charge. When the vector/plasmid weight ratio was 21, G3-acetal-NH2 improved transfection of pMAX GFP plasmid by 5-fold over native G4-NH2 in NIH3T3 cells in terms of GFP protein expression. Taken together, we show that this surface charge conversion performance makes the synthesized heterogeneous dendrimer an improved vehicle for gene transfection.Light-driven CO2 reduction was performed in a two-electrode photoelectrochemical cell (PEC) composed of a Co4O4 cubane complex-modified BiVO4 photoanode and a cobalt phthalocyanine complex-modified carbon cloth (cc) cathode. The hybrid electrodes assembled by the simple physical absorption of hydrophobic molecular catalysts exhibit long-term stability in an aqueous solution. Under 1 sun AM 1.5 G illumination, simultaneous oxygen and CO evolution at an approximately 21 ratio were achieved in a CO2-saturated NaHCO3 aqueous solution with high faradic efficiency up to 87% for CO production. Control experiments revealed a crucial role of immobilized molecular catalysts in promoting the activity and selectivity for both half-reactions. A solar-to-CO conversion efficiency of 0.44% was realized at a cell potential of 0.8 V, which is the highest efficiency for CO2 to CO conversion in PEC devices based on noble-metal-free materials.The oxygen octahedral rotation around the out-of-plane axis is explored to study its effect on metastable status, magnetic cluster glass in manganite. The antiphase rotation around the out-of-plane axis (TiO6a0a0c-) of SrTiO3 enhances the Mn-O bond anisotropy along in-plane and out-of-plane directions and weakens the ferromagnetic interactions in a 12 nm Pr0.67Sr0.33MnO3 film on the (001) SrTiO3 substrate, which together promote the formation of magnetic cluster-glassiness and enlarges the irreversible magnetoresistance (MR) effect with enhanced relaxation time of charge carriers. The effect of TiO6a0a0c- in the SrTiO3 substrate on material properties is obvious with a large irreversible MR effect for thin films, which fades away with the increase in film thickness. At 10 K, the irreversible MR is 0.91 for the 12 nm film and 0.22 for the 30 nm film. This work extends current understanding on interfacial coupling to metastable status and could help explore other systems in the perovskite structure with octahedral rotation.Many experimental and clinical studies have proven that the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tropism to the nervous system. The infection of the nervous system by SARS-CoV-2 can occur via the nasal route through trans-synaptic pathways. Coronaviruses can infect neurons and glial cells through angiotensin-converting enzyme 2 (ACE2) receptors or by endocytosis. The infection of the central nervous system (CNS) with the systemic inflammation associated with Coronavirus Disease 2019 (COVID-19) leads to the impairment of the blood-brain barrier and triggers a neuroinflammatory response with reactive astrogliosis, and microglial activation. In addition, brain stem cells are damaged, which results in respiratory distress. Apart from typical symptoms of COVID-19 related to the involvement of the respiratory system, neurological manifestations such as headache, dizziness, myalgia, anosmia, ageusia, encephalopathy, encephalitis, stroke, epileptic seizures, rhabdomyolysis and the Guillain-Barre syndrome (GBS) are associated with SARS-CoV-2 infection. In the study, attention was paid to the currently known neurological manifestations of COVID-19 so that they could be considered mainly in COVID-19 asymptomatic patients, which may limit the transmission of coronavirus infection.Two Phase 2 studies investigated the effect of a fixed-dose combination foam containing calcipotriene monohydrate (Cal) and betamethasone dipropionate (BD) on scalp psoriasis in adult and adolescent patients. Patients had psoriasis classified as at least 'mild’ per PGA. NCT01536938 enrolled adult patients (≥18 years) randomized 111 to once-daily (QD) Cal/BD foam (Cal 0.005%, BD 0.064%), Cal foam (0.005%) or BD foam (0.064%). NCT02387853 enrolled adolescent patients (12- less then 17 years) to Cal/BD foam QD (dose as previously). Treatment success was based on improvement in PGA classification at week 4. Additional efficacy endpoints included mPASI in adults and effect on extent of scalp surface area (SSA) in adolescents. Safety was also assessed. Overall, 302 adults (n=100 Cal/BD foam; n=101 Cal foam; n=101 BD foam) and 106 adolescents received treatment. Treatment success in adults was significantly higher with Cal/BD vs Cal foam (53.0% vs 35.6%, P=0.021) and numerically higher than with BD foam (47.5%, P=0.45). Mean percentage changes in mPASI were -80.0%, -57.8% and -71.2%, for Cal/BD, Cal and BD foam, respectively. In adolescents, 73.6% of patients treated with Cal/BD foam achieved treatment success and mean SSA fell from 50.6% at baseline to 12.5% at week 4. All treatment-related AEs were considered mild-to-moderate across both studies, except one severe AE (hypersensitivity reaction with urticaria) in the adult Cal/BD foam group, which led to withdrawal from the study. In these studies, treatment of scalp psoriasis with Cal/BD foam provided good efficacy for adults and adolescents and was generally well tolerated. J Drugs Dermatol. 2020;19(8) doi10.36849/JDD.2020.5168.

Neonatal diabetes mellitus (NDM) may be transient or permanent, and the majority is caused by genetic mutations. Early diagnosis is essential to select the patients who will respond to oral treatment. In this investigation, we aimed to present the phenotype and genotype of our patients with NDM and share our experience in a single tertiary center.

A total of 16 NDM patients from 12 unrelated families are included in the study. The clinical presentation, age at the diagnosis, perinatal and family history, consanguinity, gender, Hemoglobin A1c (HbA1c), C-peptide, insulin, insulin autoantibodies, genetic mutations, and response to treatment are retrospectively evaluated.

The median age at diagnosis of diabetes was five months (4 days-18 months), 6 patients with a confirmed genetic diagnosis were diagnosed after 6 months. Three patients had

mutations, six had

mutations, three had

mutations, and one had a

mutation. All the permanent NDM patients with

and

mutations were started on SU treatment resulting in a significant increase in C-peptide level, better glycemic control, and discontinuation of insulin.

Although NDM is defined as diabetes diagnosed during the first six months of life, and a diagnosis of type 1 diabetes is known much more common between the ages of 6 and 24 months, in rare cases it may present as late as 12 or even 24 months of age. Molecular diagnosis in NDM is important for planning treatment and predicting prognosis. Therefore, genetic testing is essential in these patients.

Although NDM is defined as diabetes diagnosed during the first six months of life, and a diagnosis of type 1 diabetes is known much more common between the ages of 6 and 24 months, in rare cases it may present as late as 12 or even 24 months of age. Molecular diagnosis in NDM is important for planning treatment and predicting prognosis. Therefore, genetic testing is essential in these patients.

The prevalence of celiac disease (CD) varies between 1% and 10% in patients with type 1 diabetes mellitus(T1DM). This study aims to determine the frequency of spontaneous recovery of celiac serology and the biopsy-proven CD frequency (BPCD) in patients with T1DM.

The data of 668 patients with celiac serology from 779 patients who were followed for the last 10 years with the diagnosis of T1DM were retrospectively evaluated.

Positive serology was detected in 103 out of 668(15.4%) patients. There was spontaneous normalization in 24(23.3%), fluctuation in 11(10.7%) and permanently positive serology in 68(66%) of these patients. In 46 out of 53(86.8%) patients with positive serology diagnosis of CD was confirmed with a biopsy (BPCD). The frequency of BPCD was 6.9%, and the serology in 76.1% of them was positive at the time of the diagnosis of T1DM. The weight, height and BMI-SDS at the time of diagnosis were lower in patients with BPCD compared to the group without CD. The anti-tissue transglutaminase-IgA le with asymptomatic and mild anti-TTG IgA level, is warranted.