Additionally, increasing serum SDC-1 level was a significant risk factor for mortality. Serum SDC-1 may be a useful biomarker for daily monitoring to detect early signs of kidney, liver and coagulation system dysfunction, and may be an important risk factor for mortality in critically ill patients.In this paper, we analyse the seismic noise at Ischia Island (Italy) with the objective of detecting the hydrothermal source signals taking advantage of the Covid-19 quiescence due to lockdown (strong reduction of anthropogenic noise). We compare the characteristics of the background noise in pre-, during and post-lockdown in terms of spectral content, energy release (RMS) and statistical moments. The continuous noise is decomposed into two independent signals in the 1-2 Hz and 2-4 Hz frequency bands, becoming sharpened around 1 Hz and 3 Hz respectively in lockdown. We propose a conceptual model according to which a dendritic system of fluid-permeated fractures plays as neighbour closed organ pipes, for which the fundamental mode provides the persistent whisper and the first higher mode is activated in concomitance with energy increases. By assuming reasonable values for the sound speed in low vapor-liquid mass fraction for a two-phase fluid and considering temperatures and pressures of the shallow aquifer fed by sea, meteoric and deep hydrothermal fluids, we estimate pipe lengths in the range 200-300 m. In this scheme, Ischia organ-like system can play both continuous whisper and transients, depending on the energy variations sourced by pressure fluctuations in the hydrothermal fluids.To access resources in commercial laying houses hens must move between levels with agility to avoid injury. This study considered whether providing ramps during rear improved the ability of birds to transition between levels. Twelve commercial flocks (2000 birds/flock) on a multi-age site were examined between 1 and 40 weeks of age. All birds had access to elevated perching structures from 4 days of age. Six treatment flocks were also provided with ramps during rear to facilitate access to these structures. Flocks were visited three times during rear and three times at lay to record transitioning behaviour and use of the elevated structures, together with scores for keel bone and feather damage. Ramp reared flocks used the elevated structures to a greater extent at rear (P = 0.001) and at lay, when all flocks had ramps, showed less hesitancy [i.e. pacing (P = 0.002), crouching (P = 0.001) and wing-flapping (P = 0.001)] in accessing levels. Mean levels of keel bone damage were reduced in ramp reared flocks (52%) compared with control flocks (64.8%) at 40 weeks of age (P = 0.028). The early life experience of the ramp reared flocks enabled specific learning that translated and persisted in later life and resulted in overall welfare benefits.Social buffering occurs when the presence of one animal attenuates another’s stress response during a stressful event and/or helps the subject to recover more quickly after a stressful event. Inconsistent previous results might reflect previously unrecognised contextual influences, such as the nature of the stimulus presented or social factors. We addressed these issues in a two-part study of horses paired with familiar (16 subjects) or unfamiliar (16 subjects) companions. Each subject performed 4 tests in a counterbalanced order novel object test (static ball)-alone or with companion; and umbrella opening test-alone or with companion. Social buffering was significantly influenced by the nature of the stimulus presented, but not by companion’s habituation status or familiarity. Importantly, the stimulus used produced differential effects on behavioural and physiological measures of buffering. A companion significantly reduced behavioural response (reactivity) in the novel object test but not in the umbrella test. However, heart rate recovered more quickly for subjects with a companion in the umbrella test but not in the novel object test. We propose that circumstances which permit greater contextual processing may facilitate demonstration of behavioural effects of social buffering, whereas buffering in response to startling events may be manifest only during post-event physiological recovery.Earth fissures caused by tectonic forces, human activities, or both seriously threaten the safety of people’s lives and properties. The Taiyuan Basin, a Cenozoic downfaulted basin located in the centre of the Fen-Wei Basin tectonic belt, in northwestern China, presents the ideal study area for a hazard assessment of earth fissures. A total of 104 earth fissures have been observed in the Taiyuan Basin, with a total length of approximately 128 km. In this paper, we proposed a probabilistic method for mapping earth fissure hazards by integrating the analytic hierarchy process (AHP), the area under the curve (AUC), and the certainty factor model (CFM). Geomorphic units, geologic formations, active faults and land subsidence zones of the Taiyuan Basin were mapped in detail. Correlations between these factors and earth fissures were evaluated through spatial modelling in ArcGIS. The AUC was introduced into the AHP to weight each factor and thus, to derive an earth fissure susceptibility map. Finally, the modelled earth fissure susceptibility was compared with a digital inventory of earth fissures to develop a probability function and map the spatial variability in failure probability through the CFM. The study indicates that active faults have the greatest contribution to the generation of earth fissures. Earth fissures are prone to develop in the piedmont alluvial-diluvial clinoplain and the transitional zone near the geomorphic boundary. This mapping procedure can assist in making rational decisions regarding urban planning and infrastructure development in areas susceptible to earth fissures.Acute gastrointestinal bleeding is the most common gastrointestinal cause for hospitalization. For high-risk patients requiring intensive care unit stay, predicting transfusion needs during the first 24 h using dynamic risk assessment may improve resuscitation with red blood cell transfusion in admitted patients with severe acute gastrointestinal bleeding. A patient cohort admitted for acute gastrointestinal bleeding (N = 2,524) was identified from the Medical Information Mart for Intensive Care III (MIMIC-III) critical care database and separated into training (N = 2,032) and internal validation (N = 492) sets. The external validation patient cohort was identified from the eICU collaborative database of patients admitted for acute gastrointestinal bleeding presenting to large urban hospitals (N = 1,526). 62 demographic, clinical, and laboratory test features were consolidated into 4-h time intervals over the first 24 h from admission. The outcome measure was the transfusion of red blood cells during each 4-h time interval. A long short-term memory (LSTM) model, a type of Recurrent Neural Network, was compared to a regression-based models on time-updated data. The LSTM model performed better than discrete time regression-based models for both internal validation (AUROC 0.81 vs 0.75 vs 0.75; P  less then  0.001) and external validation (AUROC 0.65 vs 0.56 vs 0.56; P  less then  0.001). A LSTM model can be used to predict the need for transfusion of packed red blood cells over the first 24 h from admission to help personalize the care of high-risk patients with acute gastrointestinal bleeding.To describe fundus autofluorescence (FAF) patterns in premature infants and to determine whether FAF increases gradually with increasing post-gestational age. This was a cross-sectional, observational and descriptive case series. FAF images were obtained from patients screened for Retinopathy of Prematurity. The presence of the following hypo-autofluorescence areas/structures was graded and ranked macular pigment (foveal centre), optic nerve head, peripapillary vessels/vascular arcade (PP/VA), and equatorial vessels (EqV). Ranks were attributed to the number of structures visualized from the posterior pole towards the periphery. The rank of FAF could then be analysed by Spearman’s correlation against age. Additionally, patients were divided by age into group 1 ( 40 WCGA than at less then  40 WCGA (8.0 [P = 0.016] and 7.5 [P = 0.03], respectively). Patterns of FAF are described for the first time in premature infants. FAF increases gradually with age and centrifugally from the posterior pole towards the equator in premature infants.Raman scattering represents the distribution and abundance of intracellular molecules, including proteins and lipids, facilitating distinction between cellular states non-invasively and without staining. However, the scattered light obtained from cells is faint and cells have complex structures, making it difficult to obtain a Raman spectrum covering the entire cell in a short time using conventional methods. This also prevents efficient label-free cell classification. In the present study, we developed the Paint Raman Express Spectroscopy System, which uses two fast-rotating galvano mirrors to obtain spectra from a wide area of a cell. By using this system and applying machine learning, we were able to acquire broad spectra of a variety of human and mouse cell types, including pluripotent stem cells and confirmed that each cell type can be classified with high accuracy. Moreover, we classified different activation states of human T cells, despite their similar morphology. This system could be used for rapid and low-cost drug evaluation and quality management for drug screening in cell-based assays.Inbreeding depression (ID) is a fundamental selective pressure that shapes mating systems and population genetic structures in plants. Although it has been shown that ID varies over the life stages of shorter-lived plants, less is known about how the fitness effects of inbreeding vary across life stages in long-lived species. We conducted a literature survey in the Pinaceae, a tree family known to harbour some of the highest mutational loads ever reported. Using a meta-regression model, we investigated distributions of inbreeding depression over life stages, adjusting for effects of inbreeding levels and the genetic differentiation of populations within species. The final dataset contained 147 estimates of ID across life stages from 41 studies. 44 Fst estimates were collected from 40 peer-reviewed studies for the 18 species to aid genetic differentiation modelling. Partitioning species into fragmented and well-connected groups using Fst resulted in the best way (i.e. trade-off between high goodness-of-fit of naged over life stages in commercial populations of long-lived plants.Species of the wood-decay genus Phylloporia (Hymenochaetaceae, Hymenochaetales, Basidiomycota) are widely distributed in the tropics. Phylloporia species are, however, morphologically and ecologically diverse, which makes morphology-based species identification challenging. In this study, we re-examined species of Phylloporia reported from Benin (West Africa). Using an integrative approach combining morphology, ecology, and phylogenetic analyses, we describe Phylloporia beninensis sp. nov. and report Phylloporia littoralis for the first time outside of its type locality. Phylloporia beninensis sp. nov. is characterized by its annual and imbricate basidiomata, duplex context with a black zone separating the upper context from the lower one, dimitic hyphal system, presence of cystidioles, basidia of 9-12 × 4-5 μm, and subglobose to ellipsoid basidiospores measuring 3-4.6 × 2.1-3.6 μm. Detailed descriptions with illustrations for the new species are provided. With the addition of the new species, 15 Phylloporia species are now known to occur in tropical Africa.