Androgen-deprivation therapy (ADT) is a systemic therapy administered for the management of advanced prostate cancer (PCa). Although ADT may improve survival, long-term use reduces bone mass density (BMD), posing an increased risk of fracture. Considering the long natural history of PCa, it is essential to preserve bone health and quality-of-life in patients on long-term ADT. As an alternative to pharmacological interventions targeted at preserving BMD, current evidence recommends lifestyle modifications, including individualized exercise and nutritional interventions. Exercise interventions include resistance training, aerobic exercise, and weight-bearing impact exercise, and have shown efficacy in preserving BMD. At the same time, it is important to take into account that PCa is a progressive and debilitating disease in which a substantial proportion of patients on long-term ADT are older individuals who harbor axial bone metastases. Smoking cessation and limited alcohol consumption are commonly recommended lifestyle measures in patients receiving ADT. Contemporary guidelines regarding lifestyle modifications vary by country, organization, and expert opinion. This comprehensive review will provide an evidence-based, updated summary of lifestyle interventions that could be implemented to preserve bone health and maintain quality-of-life throughout the disease course of PCa.Public health interventions to manage the cardio-metabolic syndrome (CMS) have had modest success, necessitating the expansion of telehealth services to where people live. This effort analyzes the association between telehealth provision and the management of CMS-related quality measures (hypertension, diabetes, weight assessment and related counseling, lipid therapy for coronary artery disease, and antiplatelet therapy for ischemic vascular disease) using the Uniform Data System administrative database during the period 2016-2018. A total of 523, 600, and 586 community health centers (CHCs) were documented using telehealth, out of the 1367, 1373, and 1362 total CHCs, in the respective three years. Our primary analysis showed that there was no association between telehealth use and the outcomes. A difference in difference approach that compared the CHCs which transitioned from not using it to using it with those that did not use telehealth in two consecutive years also produced null results. However, among rural areas, the odds of better managing the outcomes were greater for certain outcomes. Our study provides limited support that the adoption of telehealth is potentially beneficial in improving certain outcomes in the CHCs setting that are based in rural areas. More specificity in data regarding the nature of telehealth implementation in the CHC setting could bring clarity in these associations.The paper presents an operational transconductance amplifier (OTA) with low transconductance (0.62-6.28 nS) and low power consumption (28-270 nW) for the low-frequency analog front-ends in biomedical sensor interfaces. The proposed OTA implements an innovative, highly linear voltage-to-current converter based on the channel-length-modulation effect, which can be rail-to-rail driven. At 1-V supply and 1-Vpp asymmetrical input driving, the linearity error in the current-voltage characteristics is 1.5%, while the total harmonic distortion (THD) of the output current is 0.8%. For a symmetrical 2-Vpp input drive, the linearity error is 0.3%, whereas THD reaches 0.2%. The linearity is robust for the mismatch and the process-voltage-and-temperature (PVT) variations. The temperature drift of transconductance is 10 pS/°C. The prototype circuit was fabricated in 180-nanometer CMOS technology.Clubroot resistance is an economically important trait in Brassicaceae crops. Although many quantitative trait loci (QTLs) for clubroot resistance have been identified in Brassica, disease-related damage continues to occur owing to differences in host variety and constant pathogen variation. Here, we investigated the inheritance of clubroot resistance in a double haploid population developed by crossing clubroot resistant and susceptible lines „09CR500” and „09CR501”, respectively. The resistance of „09CR500” to Plasmodiophora brassicae pathotype „Banglim” was controlled as a single dominant gene, with the segregation of resistance and susceptibility being nearly 11. PbBrA08Banglim was identified as having a logarithm of odds value of 7.9-74.8, and a phenotypic variance of 26.0-97.1% with flanking marker „09CR.11390652” in A08. After aligning QTL regions to the B. rapa reference genome, 11 genes were selected as candidates. PbBrA08Banglim was located near Crr1, CRs, and Rcr9 loci, but differences were validated by marker analysis, gene structural variations, and gene expression levels, as well as phenotypic responses to the pathotype. Genotyping using the „09CR.11390652” marker accurately distinguished the Banglim-resistance phenotypes in the double haploid population. Thus, the developed marker will be useful in Brassica breeding programs, marker-assisted selection, and gene pyramiding to identify and develop resistant cultivars.Contrary to its daytime counterpart, nighttime visible and near infrared (VIS/NIR) satellite imagery is limited in both spectral and spatial resolution. Nevertheless, the relevance of such systems is unquestioned with applications to, e.g., examine urban areas, derive light pollution, and estimate energy consumption. To determine optimal spectral bands together with required radiometric and spatial resolution, at-sensor radiances are simulated based on combinations of lamp spectra with typical luminances according to lighting standards, surface reflectances, and radiative transfers for the consideration of atmospheric effects. Various band combinations are evaluated for their ability to differentiate between lighting types and to estimate the important lighting parameters efficacy to produce visible light, percentage of emissions attributable to the blue part of the spectrum, and assessment of the perceived color of radiation sources. The selected bands are located in the green, blue, yellow-orange, near infrared, and red parts of the spectrum and include one panchromatic band. However, these nighttime bands tailored to artificial light emissions differ significantly from the typical daytime bands focusing on surface reflectances. Compared to existing or proposed nighttime or daytime satellites, the recommended characteristics improve, e.g., classification of lighting types by >10%. The simulations illustrate the feasible improvements in nocturnal VIS/NIR remote sensing which will lead to advanced applications.Pulse oximetry enables oxygen saturation estimation ( S p O 2) non-invasively in real time with few components and modest processing power. With the advent of affordable development kits dedicated to the monitoring of biosignals, capabilities once reserved to hospitals and high-end research laboratories are becoming accessible for rapid prototyping. While one may think that medical-grade equipment differs greatly in quality, surprisingly, we found that the performance requirements are not widely different from available consumer-grade components, especially regarding the photodetection module in pulse oximetry. This study investigates how the use of candidate light sources and photodetectors for the development of a custom S p O 2 monitoring system can lead to inaccuracies when using the standard computational model for oxygen saturation without calibration. Following the optical characterization of selected light sources, we compare the extracted parameters to the key features in their respective datasheet. We then quantify the wavelength shift caused by spectral pairing of light sources in association with photodetectors. Finally, using the widely used approximation, we report the resulting absolute error in S p O 2 estimation and show that it can lead up to 8% of the critical 90-100% saturation window.Phospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate the action of Asp-49 Ca2+-dependent secreted phospholipase A2 (sPLA2) (MT-III) and Lys-49 sPLA2 (MT-II), two group IIA phospholipase A2s isolated from the venom of the snake Bothrops asper, on human peripheral blood monocytes. MT-III is catalytically active, whereas MT-II lacks enzyme activity. A large decrease in the fatty acid content of membrane phospholipids was detected in MT III-treated monocytes. The significant diminution of the cellular content of phospholipid-bound arachidonic acid seemed to be mediated, in part, by the activation of the endogenous group IVA cytosolic phospholipase A2α. MT-III triggered the formation of triacylglycerol and cholesterol enriched in palmitic, stearic, and oleic acids, but not arachidonic acid, along with an increase in lipid droplet synthesis. Additionally, it was shown that the increased availability of arachidonic acid arising from phospholipid hydrolysis promoted abundant eicosanoid synthesis. The inactive form, MT-II, failed to produce any of the effects described above. These studies provide a complete lipidomic characterization of the monocyte response to snake venom group IIA phospholipase A2, and reveal significant connections among lipid droplet biogenesis, cell signaling and biochemical pathways that contribute to initiating the inflammatory response.Plectranthus ecklonii Benth. has widespread ethnobotanical use in African folk medicine for its medicinal properties in skin conditions. In this study, two different basic formulations containing P. ecklonii extracts were prepared, one in an organic solvent and the other using water. The aqueous extract only contained rosmarinic acid (RA) at 2.02 mM, and the organic extract contained RA and parvifloron D at 0.29 and 3.13 mM, respectively. RA in aqueous solution permeated skin; however, in P. ecklonii organic extract, this was not detected. Thus, P. ecklonii aqueous extract was further studied and combined with benzophenone-4, which elevated the sun protection factor (SPF) by 19.49%. No significant cytotoxic effects were observed from the aqueous extract. The Staphylococcus epidermidis strain was used to determine a minimum inhibitory concentration (MIC) value of 10 µg.mL-1. The aqueous extract inhibited the activity of acetylcholinesterase by 59.14 ± 4.97%, and the IC50 value was 12.9 µg.mL-1. The association of the P. ecklonii extract with a UV filter substantially elevated its SPF efficacy. Following the multiple bioactivities of the extract and its active substances, a finished product could be claimed as a multifunctional cosmeceutical with broad skin valuable effects, from UV protection to antiaging action.Movement analysis of human body parts is momentous in several applications including clinical diagnosis and rehabilitation programs. The objective of this research is to present a low-cost 3D visual tracking system to analyze the movement of various body parts during therapeutic procedures. Specifically, a marker based motion tracking system is proposed in this paper to capture the movement information in home-based rehabilitation. Different color markers are attached to the desired joints’ locations and they are detected and tracked in the video to encode their motion information. The availability of this motion information of different body parts during the therapy can be exploited to achieve more accurate results with better clinical insight, which in turn can help improve the therapeutic decision making. The proposed framework is an automated and inexpensive motion tracking system with execution speed close to real time. The performance of the proposed method is evaluated on a dataset of 10 patients using two challenging matrices that measure the average accuracy by estimating the joints’ locations and rotations.