Height and body mass exhibited large correlations with VIFT (r = 0.835 and r = 0.699, respectively) and small correlations with ASR (r = 0.177 and r = 0.256, respectively). The CMJ was largely correlated with VIFT (r = 0.631 to r = 0.650) while presenting small correlations with ASR (r = 0.227 to r = 0.232). Both VIFT and ASR had moderate (r = 0.3 to r = 0.5) correlations with sprinting time at different distances and very large correlations with MSS (r = 0.797 to r = 0.866). The COD time was largely correlated with VIFT (r = 0.765 and r = 0.775) while exhibiting small-to-moderate correlations with ASR (r = -0.279 and r = -0.301). In conclusion, it was found that locomotor performance at 30-15 VIFT presents high levels of correlation with anthropometry and physical fitness; ASR also presents correlations with these variables, but they are smaller. This suggest that ASR is an independent variable that should be considered for inclusion in information for characterizing players’ capacities.Our study examined the effect of 8 weeks of high-intensity interval training (HIIT) and spirulina supplementation on the humoral immunity, cardio-respiratory fitness, and body composition of overweight and obese women. Thirty sedentary women (height 161.7 ± 2.8 cm, body mass 75.8 ± 8.4 kg, body mass index [BMI] 28.8 ± 2.5 kg/m2, age 25.1 ± 6.7 years) were divided into three groups placebo with HIIT group, spirulina group (SG), or combined group (CG). Exercise groups performed HIIT for 8 weeks, with three sessions per week and four to seven repetitions in each session of 30 s running and 30 s walking; the intensity was established at 90% of the maximum heart rate. Supplementation groups received 6 g of spirulina powder per day. Fasting blood samples were collected before and after 8 weeks to determine the concentrations of immunoglobulins (IgA and IgG). There was a significant group-by-time interaction for fat free mass (FFM; p = 0.001, f = 8.52, ηp2 = 0.39) and IgA (p = 0.036, f = 3.86, ηp2 = 0.22). The post hoc analysis revealed that CG reduced FFM significantly (p = 0.012, g = -0.55) after training. CG and SG showed significantly greater IgA concentrations after 8 weeks (p = 0.02, g = 0.70 and p = 0.001, g = 0.34, respectively). We conclude that spirulina supplementation with HIIT affects the body composition (lower FFM) but also boosts IgA, which plays an important role in the immune system.Chronic heart failure (CHF) results when the heart cannot consistently supply the body’s tissues with oxygen and required nutrients. CHF can be categorized as heart failure (HF) with preserved ejection fraction (HFpEF) or HF with reduced ejection fraction (HFrEF). There are different causes and mechanisms underlying HF pathogenesis; however, inflammation can be regarded as one of the factors that promotes both HFrEF and HFpEF. Monocytes, a subgroup of leukocytes, are known to be cellular mediators in response to cardiovascular injury and are closely related to inflammatory reactions. These cells are a vital component of the immune system and are the source of macrophages, which participate in cardiac tissue repair after injury. However, these monocytes are not as homogenous as thought and can present different functions under different cardiovascular disease conditions. In addition, there is still an open question regarding whether the functions of monocytes and macrophages should be regarded as causes or consequences in CHF development. Therefore, the aim of this work was to summarize current studies on the functions of various monocyte subsets in CHF with a focus on the role of a certain monocyte subset in HFpEF and HFrEF patients, as well as the subsets’ relationship to inflammatory markers.When studying the evolution of the use of medicinal plants, it is important to identify what role, and to what extent, external factors and local biocultural diversities play in shaping cultural changes. We chose as a case study, which forms part of a larger project, a religiously and linguistically distinct group, the Seto, and compared their current and past plant use with that of the surrounding Võro. Ethnobotanical fieldwork was conducted in the summers of 2018 and 2019. Current uses of plants constituted 34% of the total registered use reports and 41% of those were used to treat general diseases or used as prophylactics. In total, the medicinal use of 86 taxa was recorded, and of these 48 were prevalent. Strong erosion (the abandonment of 43, mainly wild taxa used historically) and valorisation of the uses shared with neighboring as well as distant regions once part of the Soviet Union, were evident, signalling the potential influence of the centralised distribution of knowledge. The results clearly show that the plant medicine-related biocultural diversities of the two groups have been considerably homogenised, eroded and influenced by the knowledge spread through various means during the Soviet era and over the last 30 years.An updated overview of the 29 threatened crop wild relatives (CWRs) endemic to Italy is presented, namely Arrhenatherum elatius subsp. nebrodense, Barbarea rupicola, Brassica baldensis, Brassica glabrescens, Brassica macrocarpa, Brassica rupestris subsp. hispida, Brassica rupestris subsp. rupestris, Brassica tardarae, Brassicatrichocarpa, Brassica tyrrhena, Brassica villosa subsp. bivonana, Brassica villosa subsp. brevisiliqua, Brassica villosa subsp. drepanensis, Brassica villosa subsp. tineoi, Brassica villosa subsp. villosa, Daucus broteroi, Daucus carota subsp. rupestris, Daucus nebrodensis, Diplotaxis scaposa, Festuca centroapenninica, Lathyrus apenninus, Lathyrus odoratus, Malus crescimannoi, Phalaris arundinacea subsp. rotgesii, Vicia brulloi, Vicia consentina, Vicia giacominiana, Vicia ochroleuca subsp. ochroleuca, Vicia tenuifolia subsp. elegans. Data concerning geographical distribution, ecology (including plant communities and habitats of the Directive 92/43/EEC), genetics (chromosome number, breeding system, and/or the existence of gene pools), threat status at the national and international level (Red Lists), key plant properties, and in situ and ex situ conservation were analyzed and shown. At present, most of the listed endemic CWRs, 23 out of 29, have no gene pool at all, so they are CWRs only according to the taxon group and not according to the gene pool concept. In addition, there is a serious lack of data on the ex situ conservation in gene banks, with 16 species identified as high priority (HP) while 22 taxa have high priority (A) for in situ conservation. With the aim of their protection, conservation, and valorization, specific and urgent actions are recommended.Glioblastoma is a devastating primary brain tumor with a median overall survival of approximately 15 months despite the use of optimal modern therapy. While GBM has been studied for decades, modern therapies have allowed for a reduction in treatment-related toxicities, while the prognosis has largely been unchanged. Adjuvant stereotactic radiosurgery (SRS) was previously studied in GBM; however, the results were disappointing. SRS is a highly conformal radiation technique that permits the delivery of high doses of ionizing radiation in 1-5 sessions while largely sparing surrounding healthy tissues. Furthermore, studies have shown that the delivery of ablative doses of ionizing radiation within the central nervous system is associated with enhanced anti-tumor immunity. While SRS is commonly used in the definitive and adjuvant settings for other CNS malignancies, its role in the preoperative setting has become a topic of great interest due to the potential for reduced treatment volumes due to the treatment of an intact tumor, and a lower risk of nodular leptomeningeal disease and radiation necrosis. While early reports of SRS in the adjuvant setting for glioblastoma were disappointing, its role in the preoperative setting and its impact on the anti-tumor adaptive immune response is largely unknown. In this review, we provide an overview of GBM, discuss the potential role of preoperative SRS, and discuss the possible immunogenic effects of this therapy.Salt stress is a serious agricultural problem threatens plant growth and development resulted in productivity loss and global food security concerns. Salt tolerant plant growth promoting actinobacteria, especially deep-sea actinobacteria are an alternative strategy to mitigate deleterious effects of salt stress. In this study, we aimed to investigate the potential of deep-sea Dermacoccus abyssi MT1.1T to mitigate salt stress in tomato seedlings and identified genes related to plant growth promotion and salt stress mitigation. D. abyssi MT1.1T exhibited plant growth promoting traits namely indole-3-acetic acid (IAA) and siderophore production and phosphate solubilization under 0, 150, 300, and 450 mM NaCl in vitro. Inoculation of D. abyssi MT1.1T improved tomato seedlings growth in terms of shoot length and dry weight compared with non-inoculated seedlings under 150 mM NaCl. In addition, increased total soluble sugar and total chlorophyll content and decreased hydrogen peroxide content were observed in tomato inoculated with D. abyssi MT1.1T. These results suggested that this strain mitigated salt stress in tomatoes via osmoregulation by accumulation of soluble sugars and H2O2 scavenging activity. Genome analysis data supported plant growth promoting and salt stress mitigation potential of D. abyssi MT1.1T. Survival and colonization of D. abyssi MT1.1T were observed in roots of inoculated tomato seedlings. Biosafety testing on D. abyssi MT1.1T and in silico analysis of its whole genome sequence revealed no evidence of its pathogenicity. Our results demonstrate the potential of deep-sea D. abyssi MT1.1T to mitigate salt stress in tomato seedlings and as a candidate of eco-friendly bio-inoculants for sustainable agriculture.To address the urgent need to accurately predict the spreading trend of the COVID-19 epidemic, a continuous Markov-chain model was, for the first time, developed in this work to predict the spread of COVID-19 infection. A probability matrix of infection was first developed in this model based upon the contact frequency of individuals within the population, the individual’s characteristics, and other factors that can effectively reflect the epidemic’s temporal and spatial variation characteristics. The Markov-chain model was then extended to incorporate both the mutation effect of COVID-19 and the decaying effect of antibodies. The developed comprehensive Markov-chain model that integrates the aforementioned factors was finally tested by real data to predict the trend of the COVID-19 epidemic. The result shows that our model can effectively avoid the prediction dilemma that may exist with traditional ordinary differential equations model, such as the susceptible-infectious-recovered (SIR) model. Meanwhile, it al distribution. It is predicted that COVID-19 is likely to coexist with humans for a long time and that it will exhibit multipoint epidemic effects at a later stage. The statistical evidence is consistent with our prediction and strongly supports our modeling results.After spinal cord injury (SCI), 80% of individuals are diagnosed with osteopenia or osteoporosis. The dramatic loss of bone after SCI increases the potential for fractures 100-fold, with post-fracture complications occurring in 54% of cases. With the age of new SCI injuries increasing, we hypothesized that a SCI-induced reduction in weight bearing could further exacerbate age-induced bone loss. To test this, young (2-3 months) and old (20-30 months) male and female mice were given a moderate spinal contusion injury (T9-T10), and recovery was assessed for 28 days (BMS, rearing counts, distance traveled). Tibial trabecular bone volume was measured after 28 days with ex vivo microCT. While BMS scores did not differ across groups, older subjects travelled less in the open field and there was a decrease in rearing with age and SCI. As expected, aging decreased trabecular bone volume and cortical thickness in both old male and female mice. SCI alone also reduced trabecular bone volume in young mice, but did not have an additional effect beyond the age-dependent decrease in trabecular and cortical bone volume seen in both sexes.