pe analysis (group C) was lost upon Bonferroni corrections (

<0.0025).

Prevalence of OHT in study population is observed to be similar to other studies both in TA and Dex treated patients. We can correlate rs34016742 involved in diabetes signaling pathway to the occurrence of ocular edematous and inflammatory conditions. Except rs133 that is involved in neuro-degeneration and myopia occurrence, none of the other SNPs identified in Caucasian population possess any correlation with OHT incidence in TA and Dex administered Indian subjects.

Prevalence of OHT in study population is observed to be similar to other studies both in TA and Dex treated patients. We can correlate rs34016742 involved in diabetes signaling pathway to the occurrence of ocular edematous and inflammatory conditions. Except rs133 that is involved in neuro-degeneration and myopia occurrence, none of the other SNPs identified in Caucasian population possess any correlation with OHT incidence in TA and Dex administered Indian subjects.

To evaluate the demographic features, location, and histopathologic results in primary eyelid tumors.

We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.

Nine hundred and eleven lesions from 874 patients were included in this study. Four hundred and forty-six (51.0%) of the patients were females and 428 (49.0%) were males. The mean age was 51.0y (range 3mo-94y). The lesions were located in the upper eyelid (418 cases, 45.9%), lower eyelid (378 cases, 41.5%), medial canthus (89 cases, 9.8%), and lateral canthus (26 cases, 2.8%). Four hundred and seventy (51.6%) lesions were located on the right side and 441 (48.4%) on the left. Of the eyelid lesions, 666 (73.1%) were benign, 230 (25.2%) malignant, and 15 (1.6%) premalignant. When the eyelid tumors were classified according to their tissue or cell of origin, 527 (57.8%) of the lesions were found to be epidermal, 171 (18.8%) adnexal, 131 (14.4%) inflammatory and infectious, and 65 (7.1%) stromal. The most common benign lesions were squamous cell papilloma (139 lesions, 15.2%), intradermal nevus (97 lesions, 10.6%), epidermoid inclusion cysts (78 lesions, 8.6%), seborrheic keratosis (60 lesions, 6.6%), and inflammatory masses (59 lesions, 6.5%). Basal cell carcinoma was the most common malignant tumor (191 lesions, 21.0%) followed by squamous cell carcinoma (16 lesions, 1.8%), sebaceous carcinoma (14 lesions, 1.5%), and malignant melanoma (5 lesions, 0.5%).

In this study, 73.1% of eyelid lesions are benign and the remaining 26.9% are premalignant and malignant. Basal cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.

In this study, 73.1% of eyelid lesions are benign and the remaining 26.9% are premalignant and malignant. Basal cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.

To compare the changes in excyclotorsion after inferior oblique (IO) recession in patients with primary and secondary inferior oblique overaction (IOOA).

We retrospectively analyzed the data obtained from patients with IOOA who underwent graded IO recession. The patients were followed up for at least 3mo after surgery. Fundus photographs were taken pre- and postoperatively, and the sum of the angles of torsion in both eyes was used to analyze changes in excyclotorsion. Patients were divided into two groups those diagnosed with primary IOOA were enrolled in the 1’IOOA group, and those diagnosed with secondary IOOA caused by superior oblique palsy (SOP) were enrolled in the 2’IOOA group. Excyclotorsion before and after surgery were compared between the two groups.

A total of 78 patients were enrolled in this study 34 eyes in the 1’IOOA group and 44 eyes in the 2’IOOA group. In the 78 patients, torsional angle significantly decreased from 15.31°±7.40° to 12.11°±6.53° after IO recession (

<0.001). Mean preoperative torsional angle was larger in the 2’IOOA group than in the 1’IOOA group (

=0.03). In both groups, excyclotorsion significantly decreased after IO recession (

=0.001 and

<0.001, respectively); however, there was no significant difference in the amounts of changes in excyclotorsion between the two groups.

Excyclotorsion is significantly larger in secondary IOOA than in primary IOOA, and a significant decrease in the torsional angle occurs after IO recession in both types of IOOA.

Excyclotorsion is significantly larger in secondary IOOA than in primary IOOA, and a significant decrease in the torsional angle occurs after IO recession in both types of IOOA.

To investigate the affecting factors of parapapillary gamma and delta zones and other fundus morphological features in high myopia.

Seventy high myopia patients were included in this retrospective observational study and 47 patients were female. Patients were divided into three groups no posterior staphyloma (no PS), PS with myopic traction maculopathy (PS with MTM), and PS without MTM using 3-dimensional magnetic resonance imaging and optical coherence tomography. MTM patients were further classified into three types [epiretinal membrane, macular hole, and macular retinoschisis (MRS)]. Diameters of the gamma and delta zones were measured among other morphometric variables using fundus photographs.

Of the 70 individuals (127 eyes), the mean age was 57.46±13.56y. In univariate analysis, morphological features changed most dramatically in PS with MTM patients, who had the largest gamma zone diameters, the largest disk-fovea distance (DFD) and disk-fovea angle, and the smallest angle kappa and vertical dis important role. These findings may provide a hint about the pathogenesis of traction in high myopia.

To evaluate the value of parameters on CT scan in predicting dysthyroid optic neuropathy (DON) and to provide guidance for early diagnosis of DON accordingly.

A total of 67 eyes of 35 patients with thyroid-associated ophthalmopathy (TAO) were included in this study. Patients were divided into 2 groups (DON group and non-DON group). Parameters were measured on high resolution CT, including muscle index (MI), superior ophthalmic vein (SOV) dilatation, extraocular muscle volume/orbit volume (MV/OV), and intracranial fat prolapsed, and be compared between these 2 groups. The relation between those parameters and visual function [visual acuity (VA) and visual field defect (VF defect)] were also evaluated.

MI and MV/OV were significantly higher in DON group (

=0.00035 and

=0.00026). No significant difference was detected regarding intracranial fat prolapse existence and SOV dilatation (

=0.37 and

=0.15). MV/OV was found to have significant negative correlation with both VF defect (

=-0.332,

=0.0273) and VA (

=-0.635,

=0.00) while MI was found to have negative linear correlation with VA only (

=-0.456,

=0.00017). The area under receiver operating characteristic curves was 0.82 for MV/OV and 0.75 for MI. The best performance in detecting DON was achieved when MV/OV is set at 0.20 with 72% sensitivity and 87% specificity and MI is set at 0.52 with 64% sensitivity and 80% specificity.

MI and MV/OV are predictive parameters for DON. Together with clinical manifestations, MV/OV≥0.2 can be used as a good indicator for DON in TAO patients.

MI and MV/OV are predictive parameters for DON. Together with clinical manifestations, MV/OV≥0.2 can be used as a good indicator for DON in TAO patients.

To quantitatively evaluate the effect of the combined use of 577-nm subthreshold micropulse macular laser (SML) and multi-point mode pan retinal laser photocoagulation (PRP) on severe non-proliferative diabetic retinopathy (NPDR) with central-involved diabetic macular edema (CIDME) using optical coherence tomography angiography (OCTA).

In this observational clinical study, 86 eyes of 86 NPDR patients with CIDME who underwent SML and PRP treatment were included. Images were obtained 1d before laser and post-laser (1d, 1wk, 1, 3, and 6mo) using AngioVue software 2.0. Best corrected visual acuity (BCVA, LogMAR), foveal avascular zone area (FAZ), choriocapillary flow area (ChF), parafoveal vessel density (PVD), capillary density inside disc (CDD), peripapillary capillary density (PCD), macular ganglion cell complex thickness (mGCCT), central macular thickness (CMT), and subfoveal choroidal thickness (ChT) were compared between pre- and post-laser treatment.

BCVA remained stable during 6mo post-laser therapy correlation with ChF and PVD in most post-laser stages.

During a 6-month follow-up period after combined use of SML and PRP therapy, BCVA remained stable and there was a decreased trend in macular edema. Blood flow increased at 1d post-laser therapy and reduced at 6mo post-laser therapy.

During a 6-month follow-up period after combined use of SML and PRP therapy, BCVA remained stable and there was a decreased trend in macular edema. Blood flow increased at 1d post-laser therapy and reduced at 6mo post-laser therapy.

To assess the effectiveness of the XEN 45 gel stent, either alone or combined with cataract surgery, in advanced stage open angle glaucoma (OAG) patients.

Retrospective and single-center study conducted on consecutive OAG patients who underwent a XEN 45 gel stent implantation surgery, between July 2017 and September 2018. The primary efficacy end-point was the mean intraocular pressure (IOP) reduction at the end of the follow-up period. Success was defined as an IOP reduction of at least 20% and an IOP value ≤18 mm Hg without (complete) or with (qualified) hypotensive medication.

Seventy-four patients (80 eyes) were included in the study. In the overall study sample, XEN implant significantly reduced IOP from 21.0 (19.8 to 22.1) mm Hg at baseline to 9.3 (8.2 to 10.4), 10.7 (9.6 to 11.9), 13.4 (12.2 to 14.7), 14.5 (13.6 to 15.4), 14.7 (13.8 to 15.6), and 14.7 (13.9 to 15.4) mm Hg at 1d, 1wk, 1, 3, 6, and 12mo of follow-up, respectively (

<0.0001 each). In the overall study population, at the end of tn with phacoemulsification, significantly reduced the IOP and the number of hypotensive medications in patients with OAG in advanced stage.

To assess the inter-device consistency of corneal curvature and central corneal thickness between Pentacam and a swept-source Fourier-domain anterior segment optical coherence tomography (AS-OCT) in ectopia lentis patients.

Totally 72 eyes of ectopia lentis patients were recruited. Central corneal thickness (CCT), corneal curvature values and corneal astigmatism were obtained from both the Pentacam and AS-OCT (CASIA2). Repeatability was evaluated for both devices. The coefficient of repeatability (COR) and the relative COR was calculated. Bland-Altman plots were conducted to evaluate the inter-device agreement of measurement. Orthogonal linear regression was used to examine any proportional bias.

The mean difference of CCT, steep anterior corneal curvature (anterior K

), flat anterior corneal curvature (anterior K

), anterior corneal astigmatism (ACA), steep posterior corneal curvature (posterior K

), flat posterior corneal curvature (posterior K

), posterior corneal astigmatism (PCA), steep true net power (TNP K

), flat true net power (TNP K

) and total corneal astigmatism (TCA) between Pentacam and CASIA2 were 7.