Primary rotational constants as well as quartic and sextic centrifugal distortion constants were determined. We also investigated vibrationally excited states of styrene oxide, and for the three lowest energy vibrational states, we determined rotational constants including centrifugal distortion corrections up to the sextic order. In addition, spectroscopic parameters for the singly-substituted 13C and 18O isotopologues were retrieved from the spectrum in natural abundance and used to determine the effective ground state structure of styrene oxide in the gas phase. The spectroscopic parameters and line lists of rotational transitions obtained here will assist future astrochemical studies of this class of chiral organic molecules.Heparin-like polymers are promising synthetic materials with biological functionalities, such as anticoagulant ability, growth factor binding to regulate cellular functions, and inflammation mediation, similar to heparin. The biocompatibility of heparin-like polymers with well-defined chemical structures has inspired many researchers to design heparin-like surfaces to explore their biological applications. The concept of the recombination of functional heparin structural units (sulfonate- and glyco-containing units) was proven to be successful in designing heparin-mimicking surfaces. However, besides surface structural units, topographic patterning is also an important contributor to the biological activity of the surfaces modified with heparin-like polymers. In this work, both surface structural units and topographic patterning were taken into account to investigate the vascular cell behaviors on the silicone surfaces. A facile method for the production of patterned bromine-containing polydimethylsiloxane sul responses to the corresponding flat surfaces. That is to say, surface patterning can make the „vascular cell-friendly” surface still friendly, and the „vascular cell-resistant” surface much more resistant. The combination of surface structural units and topographic patterning shows promise in the preparation of new heparin-like surfaces with improved cell compatibility that is suitable for blood-compatible biomaterials.Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free „organelles” within coacervate-based protocells.We demonstrate herein a newly designed benzothiadiazole-based covalent organic framework through an imine linkage with high crystallinity, excellent chemical stability and significant light absorption ability, which was further applied as a high-performance platform for efficient visible-light driven hydrogen evolution.The catalysis of inverting glycosyltransferases consists of several biophysical and biochemical processes during which the transfer of a sugar residue from the purine phosphate donor substrate to an acceptor substrate occurs with stereo-inversion of the anomeric C1 center at a product. During catalysis a highly charged phosphate by-product (UDP3-) is formed and a mechanism of how the enzyme stabilizes it back to the UDP2- form is not known. Using methods of molecular modeling (hybrid DFT-QM/MM calculations) we proposed and validated a catalytic mechanism of bovine inverting β-1,4-galactosyltransferase-1 (β4Gal-T1) with native (UDP-galactose) and thio donor substrates (UDP-5′ thio galactose). We focused on three aspects of the mechanism not yet investigated (i) the formation of an oxocarbenium ion intermediate, which was only found for the retaining glycosyltransferases for the time being; (ii) the mechanism of stabilization of a highly charged phosphate by-product (UDP3-) back to its standard in vivo form (UDP2-); (iii) explanation for why in experimental measurements the rate of catalysis with the thio donor substrate is only 8% of the rate of that with the natural substrate. To understand the differences in the interaction patterns between the complexes enzyme  UDP-Gal and enzyme  UDP-5S-Gal, fragmented molecular orbital (FMO) decomposition energy analysis was carried out at the DFT level.Metal-organic frameworks (MOFs) featured with flexible design and versatile properties are finding increasing applications. In particular, integrating multiple functions into one framework can bring them improved detection efficiency towards various analytes. Herein, for the first time, a Fe-Zr bi-metal-organic framework (UiO-66(Fe/Zr)-NH2) with three functions (intrinsic fluorescence, peroxidase-mimicking activity, and specific recognition) is designed to establish a ratiometric fluorescent platform for high-performance phosphate ion (Pi) sensing. The use of a fluorescent organic ligand endows the MOF material with a strong intrinsic fluorescence at 435 nm. The presence of Fe3+/Fe2+ nodes offers good enzyme-like capacity to catalyze the o-phenylenediamine (OPD) substrate to fluorescent OPDox (555 nm), which then quenches the intrinsic fluorescence of UiO-66(Fe/Zr)-NH2 due to the inner filter effect. The Zr4+ nodes in the MOF material act as selective sites for Pi recognition. When Pi exists, it specifically adsorbs onto UiO-66(Fe/Zr)-NH2 and decreases the latter’s peroxidase-mimetic activity, resulting in the less production of fluorescent OPDox. As a consequence, the intrinsic fluorescence of UiO-66(Fe/Zr)-NH2 at 435 nm is restored, and the signal from OPDox at 555 nm is reduced inversely. With the ratiometric strategy, efficient determination of Pi with outstanding sensitivity and selectivity was realized, giving a detection limit down to 85 nM in the concentration range of 0.2-266.7 μM. Accurate measurement of the target in practical water matrices was also validated, indicating its promising application for Pi analysis in environmental and other fields.Lead cyanamide PbNCN was synthesized by solid-state metathesis between PbCl2 and Na2NCN in a 1  1 molar ratio, and its structure was confirmed from Rietveld refinement of X-ray data. Electronic-structure calculations of HSE06 density-functional type reveal PbNCN to be an indirect semiconductor with a band gap of 2.4 eV, in remarkable quantitative agreement with the measured value. Mott-Schottky experiments demonstrate PbNCN to be a p-type semiconductor with a flat-band potential of 2.3 eV vs. the reversible hydrogen electrode (RHE) which is commonly used to estimate the value of the valence band edge position. Moreover, thin films of powderous PbNCN were assembled into a photoelectrode for photoelectrochemical water splitting. On the example of p-type PbNCN, this study provides the first experimental evidence that MNCN compounds can be applied as photocathodes for reductive reactions in photoelectrochemical cells.Drugs that block voltage-gated sodium channels (NaVs) have utility in treating conditions including pain, epilepsy, and cardiac arrhythmias and as anesthetics (Lancet Neurol.20109413424; Expert Opin. Ther. Pat.201020755779). The identification of compounds with improved efficacy and safety is a key aim for the discovery of improved NaV blocking drugs (Comprehensive Medicinal Chemistry III; (Elsevier, 2017; pp 131-175). We report the identification of a novel class of brain penetrant and voltage-gated sodium channel blockers, leading to the discovery of vixotrigine, a use-dependent sodium channel blocker with activity in in vivo models of pain. Vixotrigine has excellent physiocochemical properties for drug development, and both preclinical and clinical data support a safety profile suitable for potential use in neuropathic pain and other conditions. It has shown efficacy in a Phase II study for pain associated with trigeminal neuralgia.

Cancer prevention and screening is a significant part of the cancer care continuum. Nurses are trusted professionals who can bring stakeholders together and serve diverse groups.

This article describes how nurses can advance cancer prevention and screening initiatives in industry, education, legislative advocacy, research, survivorship, and program development and support.

An online search and collaborative knowledge revealed examples of nurses leading the way in cancer prevention and screening efforts.

Nurse-driven cancer prevention and screening collaborations advance care farther and faster. By creating maximum impact and mobilizing individual passion for a project, any nurse can find collaborative niche opportunities in clinical practice.

Nurse-driven cancer prevention and screening collaborations advance care farther and faster. By creating maximum impact and mobilizing individual passion for a project, any nurse can find collaborative niche opportunities in clinical practice.

Prevention strategies help to teach what individuals can do to potentially offset cancer risks. Screenings can detect cancer at earlier stages, allowing for earlier treatments and better outcomes.

This article seeks to identify best practices in cancer prevention and screening.

This article presents exemplars in oncology nursing that illustrate implementation of best practices for cancer prevention and screening.

Oncology nurses are well situated to not only provide education about prevention activities, but also to encourage participation in recommended screenings. Implementation of evidence-based practice, along with the nurses’ clinical knowledge and patient preferences, allows for the best outcomes for patients. The use of exemplars is an ideal way of telling nurses’ stories to share their experiences and how they affected patient outcomes.

Oncology nurses are well situated to not only provide education about prevention activities, but also to encourage participation in recommended screenings. Implementation of evidence-based practice, along with the nurses’ clinical knowledge and patient preferences, allows for the best outcomes for patients. The use of exemplars is an ideal way of telling nurses’ stories to share their experiences and how they affected patient outcomes.

Although most cancer survivors adhere to recommendations to refrain from tobacco and minimize alcohol use, survivors of certain cancers are not meeting these recommendations. In addition, most cancer survivors do not achieve optimal recommendations for diet and physical activity, further decreasing survivor health and quality of life. Sun protective and sleep behaviors also tend to be suboptimal among survivors. Uptake of age-appropriate vaccinations is variable among survivors.

The purpose of this article is to review the prevalence of healthy behavior uptake among cancer survivors and provide nurses with an overview of effective interventions, strategies, and resources to help patients improve these behaviors.

An expert panel was convened to conduct an integrative review and synthesis on the state of the science of healthy behavior uptake among cancer survivors.

Not meeting recommendations for healthy lifestyle behaviors increases the risk of second cancers and mortality and decreases overall health and quality of life. Healthy lifestyle behaviors can contribute to improved function, quality of life, and overall survival for cancer survivors. Nurses can help survivors to understand and improve their behaviors.

Not meeting recommendations for healthy lifestyle behaviors increases the risk of second cancers and mortality and decreases overall health and quality of life. Healthy lifestyle behaviors can contribute to improved function, quality of life, and overall survival for cancer survivors. Nurses can help survivors to understand and improve their behaviors.