These data mirror recent studies on diatom intraspecific genetic diversity, which has found comparable levels of genetic diversity at a single site to those thousands of kilometres apart, and provide evidence of a functional role of diatom diversity that will allow for rapid adaptation via ecological selection on standing variation in response to changing conditions.

Abdominal cavity access accounts for 50% of complications during laparoscopic surgery. Different safety maneuvers have been used to try to diminish these. Our study aims to establish the usefulness of Palmer’s test in the correct positioning of the Veress needle and the reduction of complications during laparoscopic access maneuvers, when used in addition to the determination of intraabdominal pressure.

Prospective observational analytic multi-centered cohort study with 370 patients undergoing gynecologic laparoscopy between July 2014 and November 2019, comparing the additional use of Palmer’s test in 185 patients (Palmer-Test-Yes, PTY), with intraabdominal pressure determination alone in 185 patients (Palmer-Test-No, PTN).

Intergroup homogeneity was described for the basic characteristics of both population samples, except for mean age and percentage of previous laparotomy. A total of 19 complications were recorded, 10 in PTY and 9 in PTN, with no significant differences (P = 0.814). No differences werof false security.

To develop and validate a frailty index (FI) from interRAI-Community Health Assessments (CHA) on older adults in retirement villages (RVs).

This is a cross-sectional analysis of a current RV research study. A FI was generated using the cumulative deficit model. Health-care utilisation measures were acute, and all, hospitalisations 12months before baseline assessment. Associations between FI and hospitalisations were explored using multivariable logistic regression to estimate odds ratio (OR).

Of 577 included residents, mean (SD) age was 81 (7) and 419 (73%) were female. Mean (SD) FI was 0.16 (0.09); 260 (45%) were mildly frail, and 108 (19%) moderate-severely frail. In multivariate-adjusted analysis, odds of acute hospitalisation for mild (OR=3.3, P<.001) and moderate-severely frail (OR=6.4, P<.001) were significantly higher than fit residents. Higher odds were also observed for all hospitalisations.

A considerable proportion of RV residents were moderately-severely frail. FI was associated with acute and all hospitalisations.

A considerable proportion of RV residents were moderately-severely frail. FI was associated with acute and all hospitalisations.Warming in the Arctic has been more apparent in the non-growing season than in the typical growing season. In this context, methane (CH4 ) emissions in the non-growing season, particularly in the shoulder seasons, account for a substantial proportion of the annual budget. However, CH4 emissions in spring and autumn shoulders are often underestimated by land models and measurements due to limited data availability and unknown mechanisms. This study investigates CH4 emissions during spring thaw and autumn freeze using eddy covariance CH4 measurements from three Arctic sites with multi-year observations. We find that the shoulder seasons contribute to about a quarter (25.6 ± 2.3%, mean ± SD) of annual total CH4 emissions. Our study highlights the three to four times higher contribution of autumn freeze CH4 emission to total annual emission than that of spring thaw. Autumn freeze exhibits significantly higher CH4 flux (0.88 ± 0.03 mg m-2 hr-1 ) than spring thaw (0.48 ± 0.04 mg m-2 hr-1 ). The mean duration of autumn freeze (58.94 ± 26.39 days) is significantly longer than that of spring thaw (20.94 ± 7.79 days), which predominates the much higher cumulative CH4 emission during autumn freeze (1,212.31 ± 280.39 mg m-2 year-1 ) than that during spring thaw (307.39 ± 46.11 mg m-2 year-1 ). Near-surface soil temperatures cannot completely reflect the freeze-thaw processes in deeper soil layers and appears to have a hysteresis effect on CH4 emissions from early spring thaw to late autumn freeze. Therefore, it is necessary to consider commonalities and differences in CH4 emissions during spring thaw versus autumn freeze to accurately estimate CH4 source from tundra ecosystems for evaluating carbon-climate feedback in Arctic.Sign language (SL) conveys linguistic information using gestures instead of sounds. Here, we apply a meta-analytic estimation approach to neuroimaging studies (N = 23; subjects = 316) and ask whether SL comprehension in deaf signers relies on the same primarily left-hemispheric cortical network implicated in spoken and written language (SWL) comprehension in hearing speakers. We show that (a) SL recruits bilateral fronto-temporo-occipital regions with strong left-lateralization in the posterior inferior frontal gyrus known as Broca’s area, mirroring functional asymmetries observed for SWL. (b) Within this SL network, Broca’s area constitutes a hub which attributes abstract linguistic information to gestures. (c) SL-specific voxels in Broca’s area are also crucially involved in SWL, as confirmed by meta-analytic connectivity modeling using an independent large-scale neuroimaging database. This strongly suggests that the human brain evolved a lateralized language network with a supramodal hub in Broca’s area which computes linguistic information independent of speech.

In patients with steno-occlusive disease, recent findings suggest that hemodynamic alterations may also be associated with crossed cerebellar diaschisis (CCD) rather than a functional disruption alone.

To use a quantitative multiparametric hemodynamic MRI to gain a better understanding of hemodynamic changes related to CCD in patients with unilateral anterior circulation stroke.

Prospective cohort study.

Twenty-four patients (25 datasets) with symptomatic unilateral anterior circulation stroke.

3T/two sequences single-shot (echo-planar imaging) EPI sequence and T

gradient echo perfusion-weighted imaging study.

The presence of CCD was inferred from the cerebellar asymmetry index (CAI) of the blood oxygenation-level dependent cerebrovascular reactivity (BOLD-CVR) exam, which was calculated from the mean BOLD-CVR and standard deviation of the CAI of the healthy control group. For all perfusion-weighted (PW)-MRI parameters, the cerebellar and middle cerebral artery (MCA) territory asymmetry indicet in the ipsilateral MCA territory, which further supports the concept of a vascular component of CCD.

3 TECHNICAL EFFICACY STAGE 3.

3 TECHNICAL EFFICACY STAGE 3.The growth of ZnO clusters supported by ZnO-bilayers on Ag(111) and the interaction of these oxide nanostructures with water have been studied by a multi-technique approach combining temperature-dependent infrared reflection absorption spectroscopy (IRRAS), grazing-emission X-ray photoelectron spectroscopy, and density functional theory calculations. Our results reveal that the ZnO bilayers exhibiting graphite-like structure are chemically inactive for water dissociation, whereas small ZnO clusters formed on top of these well-defined, yet chemically passive supports show extremely high reactivity – water is dissociated without an apparent activation barrier. Systematic isotopic substitution experiments using H216 O/D216 O/D218 O allow identification of various types of acidic hydroxyl groups. We demonstrate that a reliable characterization of these OH-species is possible via co-adsorption of CO, which leads to a red shift of the OD frequency due to the weak interaction via hydrogen bonding. The theoretical results provide atomic-level insight into the surface structure and chemical activity of the supported ZnO clusters and allow identification of the presence of under-coordinated Zn and O atoms at the edges and corners of the ZnO clusters as the active sites for H2 O dissociation.Data on cognitive function after pLT are rare, particularly regarding children with cognitive impairment. From 2016 to 2018, we evaluated cognitive function in 36 patients after pLT aged 6-17 years with the WISC IV (at least 1 year after transplantation) and analyzed potential risk factors for cognitive impairment (IQ less then 70) by means of retrospective medical data (peri-, intra-, and post-operative factors, and donor and specific organ data of the primary liver transplant) on an exploratory base. At a median age of 9.6 years (range = 6-16.9), 22% of patients were cognitive impaired (IQ less then 70; including five untestable patients with severe cognitive impairment). Children tested with the WISC IV scored within the lower normal range but differed significantly from normal population. Strongest associations showed infections at pLT, development of severe sepsis requiring intensive care within the first 6 months after pLT, neurological complications within the first 10 days and the occurrence of CPR during or after pLT, and as early laboratory variables pH value on day 0 after pLT. In our analysis, neither intraoperative factors nor donor-specific factors seemed to influence cognitive outcome. In our small cohort, medical complications before and after pLT but not transplantation itself had an influence on cognitive outcome. As such, children experiencing medical problems before and in the early post-operative phase after pLT should be closely evaluated in larger samples regarding their neurological and psychomotor development during vulnerable phases and should receive early educational support to improve long-term cognitive function.The 'Experienced Involvement’ (EX-IN) training programme prepares and certifies individuals who have experienced mental health problems to work as peer support workers and to support others challenged by similar conditions. We aimed to assess the impact of the EX-IN training on hope, self-efficacy, introspection, stigma resistance, personal recovery, health-related quality of life and employment in participants. Data was collected using standardized assessment instruments before the training started (t1) and upon course completion (t2). Data from 103 participants who participated in both measurement times were included into data analysis. Participants significantly improved their recovery, stigma resistance and introspection during the EX-IN training. In addition, a significant higher proportion of participants were employed at t2. Participants whose last inpatient stay was 0-1 year before the start of the EX-IN training showed significantly lower levels of stigma resistance, and self-efficacy at t1 than participants with two or more years since the last inpatient stay. There were no significant changes in mean values over time, or in the mean values at t2 between the two groups. EX-IN training has a positive influence on the handling of stigma, on one’s recovery path and introspection. This indicates that EX-IN training has a therapeutic effect on the participants. EX-IN training seems to meet the challenges of peer support work. Therefore, the training can be recommended as preparation for working as a peer support worker as well as an intervention to improve one´s recovery process.The discovery of extensive plant and animal fossil allows to paint a more detailed picture of how mammals arose after the demise of the dinosaurs 66 million years ago.