Our data highlight that the sequence diversity within this family results in equally diverse structures. None of these nine PLPs showed antibacterial or antifungal activity.Light-powered fuel-free colloidal motors possess significant potential for practical applications ranging from nanomedicine to environmental remediation. However, current light-powered colloidal motors often require the incorporation of expensive metals or high concentrations of toxic chemical fuels, which is a severe limitation for their practical applications. Integrating highly ordered and porous materials with a large surface area into colloidal motors is a promising strategy for upsurging their self-propelled speed and adsorption, which will benefit many applications. Here, highly efficient, fuel-free, and light-activated metal organic framework (MOF)-3-trimethoxysilyl propyl methacrylate Janus colloidal motors with a hierarchical morphology are reported. These colloidal motors can be driven by UV or visible light, with a self-propelled speed tuned by the light intensity. The speed can be further enhanced by morphology optimization or by the addition of H2O2 as a fuel. The colloidal motors display a superior efficiency in removing heavy metal ions of Hg, which is up to ∼90% within 40 min from the contaminated water, attributed to their high surface area, hierarchical morphology, large number of active sites, and high mobility. This work not only offers a facile approach to incorporate a versatile MOF family into the design of fuel-free and light-powered Janus colloidal motors, but also demonstrates their potential for real-life applications such as environmental remediation.Renal-clearable and target-responsive near-infrared (NIR) fluorescent imaging probes have been promising for in vivo diagnosis of acute kidney injury (AKI). However, designing an imaging probe that is renal-clearable and concurrently responsive toward multiple molecular targets to facilitate early detection of AKI with improved sensitivity and specificity is challenging. Herein, by leveraging the receptor-mediated binding and retention effect along with enzyme-triggered fluorescence activation, we design and synthesize an activatable small-molecule NIR fluorescent probe (1-DPA2) using a „one-pot sequential click reaction” approach. 1-DPA2 can target both the externalized phosphatidylserine (PS) and active caspase-3 (Casp-3), two essential biomarkers of apoptosis, producing enhanced 808 nm NIR fluorescence and a high signal-to-background ratio (SBR) amenable to detecting the onset of cisplatin-induced AKI in mice as early as 24 h post-treatment with cisplatin. We not only monitor the gradual activation of Casp-3 in the kidney of mice upon AKI progression but also can report on the progressive recovery of kidney functions in AKI mice following N-acetyl-l-cysteine (NAC) therapy via real-time fluorescence imaging by 1-DPA2. This study demonstrates the ability of 1-DPA2 for longitudinal monitoring of renal cell apoptosis by concurrently targeting PS externalization and Casp-3 activation, which is efficient for early diagnosis of AKI and useful for prediction of potential drug nephrotoxicity as well as in vivo screening of anti-AKI drugs’ efficacy.Paper-based fluorescence devices, with smartphone aids, bring considerable operation convenience for tetracycline (TC) sensing. Nevertheless, they must meet the challenge in real determination against complicated backgrounds. Considering that, we present a programmable-printing paper-based device and then apply it to TC determination for various natural samples. MoS2 NPs and Gmp/Eu-Cit are synthetized as composite probes. A static quenching process is found with MoS2 NP fluorescence at 430 nm, while significant magnification of Gmp/Eu-Cit emission is obtained at 617 nm, establishing a valuable ratiometric indicator. Remarkably, two-stage programmable printing maximizes the proposed sensing capability. A transitive device, containing a gradually changing amount of a certain probe, is prepared to sense TC. With a homemade smartphone application and 3D-printed measurement chamber, the corresponding signals are examined to explore optimal setups. These setups are automatically processed to prepare the final-version device, not requiring manual operations. Benefitting from this interesting feature, the proposed device gains many rewards in performances. It effectively senses TC in a wide range from 12.7 nM to 80 μM and simultaneously provides naked eye-legible signals and smartphone-based readouts with confident selectivity and stability. This device is consequently applied for various samples of soil, river water, milk, and serum and meets well with HPLC-MS and recovery tests.Direct formate fuel cells (DFFCs) as promising energy technologies have been applied for portable and wearable devices. However, for the formate oxidation reaction (FOR), the deficiency of catalysts has prevented DFFCs from practical applications. Herein, we prepared a Pd-loaded CeO2 catalyst through a simple steam treatment at 400 °C to enhance the catalytic FOR performance. In comparison with the counterpart of Pd/CeO2 without stream treatment, the as-prepared Pd/CeO2-ST catalyst has a lower onset potential of 381 mV and a lower peak potential of 0.64 V with a higher peak current of 10.62 mA cm-2. The experimental results show that the enhanced FOR properties of Pd/CeO2-ST are ascribed to the introduction of surface reactive oxygen species to the CeO2 substrate, which substantially promotes the desorption of adsorbed hydrogen (H*) intermediates. Density functional theory (DFT) calculations reveal that on the surface of CeO2, the abundant oxygen vacancies boost the OH* adsorption ability and accelerate the kinetics of the potential-limiting step. This work not only proposes a new strategy for enhancing the activity of FOR catalysts but also highlights the understanding of the FOR mechanism in alkaline media for DFFC applications.Hyperuricemia is a metabolic disease caused by impaired uric acid (UA) metabolism. Ellagic acid (EA) is a natural small-molecule polyphenolic compound with known antioxidative and anti-inflammatory properties. Here, we evaluated the regulatory effects of EA on hyperuricemia and explored the underlying mechanisms. We found that EA is an effective xanthine oxidase (XOD) inhibitor (IC50 = 165.6 μmol/L) and superoxide anion scavenger (IC50 = 27.66 μmol/L). EA (5 and 10 μmol/L) treatment significantly and dose-dependently reduced UA levels in L-O2 cells; meanwhile, intraperitoneal EA administration (50 and 100 mg/kg) also significantly reduced serum XOD activity and UA levels in hyperuricemic mice and markedly improved their liver and kidney histopathology. EA treatment significantly reduced the degree of foot edema and inhibited the expression of NLPR3 pathway-related proteins in foot tissue of monosodium urate (MSU)-treated mice. The anti-inflammatory effect was also observed in lipopolysaccharide-stimulated RAW-264.7 cells. Furthermore, EA significantly inhibited the expressions of XOD and NLRP3 pathway-related proteins (TLR4, p-p65, caspase-1, TNF-α, and IL-18) in vitro and in vivo. Our results indicated that EA exerts ameliorative effects in experimental hyperuricemia and foot edema via regulating the NLRP3 signaling pathway and represents a promising therapeutic option for the management of hyperuricemia.New strategies to access radicals from common feedstock chemicals hold the potential to broadly impact synthetic chemistry. We report a dual phosphine and photoredox catalytic system that enables direct formation of sulfonamidyl radicals from primary sulfonamides. Mechanistic investigations support that the N-centered radical is generated via α-scission of the P-N bond of a phosphoranyl radical intermediate, formed by sulfonamide nucleophilic addition to a phosphine radical cation. As compared to the recently well-explored β-scission chemistry of phosphoranyl radicals, this strategy is applicable to activation of N-based nucleophiles and is catalytic in phosphine. We highlight application of this activation strategy to an intermolecular anti-Markovnikov hydroamination of unactivated olefins with primary sulfonamides. A range of structurally diverse secondary sulfonamides can be prepared in good to excellent yields under mild conditions.Layered double hydroxides (LDHs) have attracted significant attention as adsorbents for the removal of anions from wastewater. However, it is challenging to develop a simple, economical, and environmentally friendly method for fabricating efficient LDH adsorbents. In this paper, we present an alternative approach for preparing a superb NiFe LDH adsorbent via a single-step topochemical synthesis method based on density functional theory (DFT) calculation. The NiFe LDH adsorbent [Ni0.75Fe0.25(OH)2]·(CO3)0.125·0.25H2O was obtained via the topotactic transformation of an oxide precursor (NaNi0.75Fe0.25O2), which was prepared by utilizing the high-temperature flux method, in ultrapure water. When the oxide precursor was soaked in ultrapure water, the host layer valence state changed from Ni3+ and Fe3+ to Ni2+ and Fe3+, and carbonate (CO32-) ions were simultaneously intercalated in the interlayer. Thereafter, the CO32- ions were deintercalated by Cl- ions to increase the adsorption capacity. The adsorbent exhibited high crystallinity, cation state, and porosity, and unique particle shape. In addition, it showed superior adsorption capacities of approximately 194.92, 176.15, and 146.28 mg g-1 toward phosphate, fluoride, and nitrate ions, respectively. The adsorption capacity toward all the anions reached over 70% within 10 min. The adsorption behavior was investigated by performing from adsorption kinetics, isotherm, and thermodynamics studies. The results showed that the anions were endothermically and spontaneously chemisorbed through an ion exchange process onto the adsorbent in a monolayer. In addition, the as-prepared NiFe LDH adsorbent showed high stability after multicycle testing.Carbon nanotube-based donor-acceptor devices are used in applications ranging from photovoltaics and sensors to environmental remediation. Non-covalent contacts between donor dyes and nanotubes are often used to optimize sensitization and scalability. However, inconsistency is often observed despite donor dye studies reporting strong donor-acceptor interactions. Here, we demonstrate that the dye binding location is an important factor in this process we used coated-acceptor chromatic responses and find that dye binding is affected by the coating layer. The emission response to free- and protein-sequestered porphyrin was tested to compare direct and indirect dye contact. An acceptor complex that preferentially red-shifts in response to sequestered porphyrin was identified. We observe inconsistent optical signals that suggest porphyrin-dye interactions are best described as coating-centric; therefore, the coating interface must be considered in application and assay design.The environment encountered by space vehicles in very low Earth orbit (VLEO, 180-350 km altitude) contains predominantly atomic oxygen (AO) and molecular nitrogen (N2), which collide with ram surfaces at relative velocities of ∼7.5 km s-1. Structural, thermal-control, and coating materials containing organic polymers are particularly susceptible to AO attack at these high velocities, resulting in erosion, roughening, and degradation of function. Copolymerization or blending of a polymer with polyhedral oligomeric silsesquioxane (POSS) yields a material that can resist AO attack through the formation of a passivating silicon-oxide layer. Still, these hybrid organic/inorganic polymers become rough through AO reactions as the passivating layer is forming. Surface roughness may enhance satellite drag because it promotes energy transfer and scattering angle randomization during gas-surface collisions. As potential low-drag and AO-resistant materials, we have investigated POSS-containing films of clear and Kapton-like polyimides that have an atomically smooth AO-resistant coating of Al2O3 that is grown by atomic layer deposition (ALD).