Conoley, Powers, and Gutkin (2020) have provided an assessment of the progress and lack thereof of school psychology as a profession toward school reformation, especially as related to their various earlier calls for changes in training and practice. Conoley and Gutkin especially (and I have been colleagues of both) have called for decades for an emphasis on working with teachers, other adults in the school system, and the school system itself to alter the delivery of education. In some earlier work, they have characterized this as adult school psychology. In many ways this is a reconceptualization of earlier mental health consultation models of school psychology practice that were not widely adopted for reasons Conoley et al. (2020) explain. School psychology has a long history of wanting to be seen and to practice differently from in a primary role of test and place, and indeed I would characterize the primary organizations that represent the profession (the National Association of Psychologists and the American Psychological Association’s Division of School Psychology) as being in many ways antagonistic toward psychological testing. Yet, it is what most school psychologists are in fact hired to do as their primary role, and training in psychological testing and assessment is one of the key skills that sets us apart and distinguishes us from others in the schools. (PsycInfo Database Record (c) 2021 APA, all rights reserved).School psychology has been criticized for limited attention to and limited evidence-based resources for diverse populations in domestic and international settings, in part because of its foundations on psychological knowledge generated primarily in North America and Western Europe. Moreover, in the past 25 years, the profession has made insufficient progress in changing its focus toward an ecological systems perspective as initially envisioned by Conoley and Gutkin in 1995 and revisited in this issue. In this article, we embrace and expand that vision to include the infusion of global and intercultural perspectives into school psychology research, training, practice, policy, and advocacy as a means to address cultural diversity within local contexts across the globe, with a particular focus on school psychology within the United States. We begin with a discussion of terminology that addresses international and cross-cultural issues related to diversity. We then examine past and present perspectives and approaches to cultural diversity and globalization within school psychology and propose future directions for research, training, practice, policy, and advocacy within a global-intercultural perspective. We conclude with our reflections about transforming school psychology and school psychologists. (PsycInfo Database Record (c) 2021 APA, all rights reserved).In this article, we reflect on the evolution of school psychology practice from the past to the present, and share some thoughts about the future. Although school psychology programs provide training in consultation, prevention, social emotional development, counseling, and mental health interventions, school psychology practice is still dominated by assessment, and the specialty has yet to live up to its promise to address the multiple needs of an increasingly diverse student population. Today’s practitioners need to be skilled in systems-level programing that is informed by cultural awareness, knowledge, and skills necessary to responsibly work toward the best outcomes for students and families from all cultural, ethnic, and racial backgrounds. As the demand for mental health and other services in schools continues to increase, we argue for a wholescale adoption of culturally adapted evidence-based practices to address the expanding role of school-based practice. Finally, we offer considerations from the social psychology literature that will help school psychologists prioritize behavioral health while also reducing disparities in educational attainment. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Conoley, Powers, and Gutkin (2020) called for an increased emphasis on models of psychological service delivery that are primarily indirect, adult-focused, and geared toward systems-level change in the schools. They asserted that research in school psychology should not focus on the problems of individual children and youth but address the „powerful ecosystems” that surround them. Although school- and system-wide interventions are certainly important and can have a positive impact on student outcomes, we contend that biopsychosocial models of human development that integrate the effects of genetics, personal characteristics and behaviors, environments, and broad social contexts are better frameworks for guiding future research in school psychology. In these models, the role of genetics is mediated by the family environment and broader social contexts to influence variability in cognitive, social-emotional, and behavioral domains of psychological functioning. These individual differences then interact with specific situations, leading to outcomes in educationally relevant behaviors, such as achievement, self-esteem, motivation, and peer relations. The focus of research in school psychology, therefore, should not be on „1 size fits all” school-wide interventions but rather on understanding how and why children and youth differ from one another and on translating research on the effects of genes, the environment, and their interplay into effective educational interventions. Research on bullying and victimization in schools is discussed as an example of the importance of taking a biopsychosocial ecological approach to studying complex behavior. (PsycInfo Database Record (c) 2021 APA, all rights reserved).This article provides reflections on several key elements important for establishing and sustaining successful research trajectories and scholarship within the field. Developed by several Lightner Witmer Award recipients, the article highlights several of Lightner Witmer’s experiences and pioneering contributions, including the importance of his own mentors, collaborations with interdisciplinary professionals, and his emphasis on the relevance of scientific research programs and the practical implications for helping children. In an effort to move the field forward, we discuss important elements relevant to developing and sustaining successful research programs in school psychology including the importance of mentorship, collaboration, research methodologies, replicability, extramural funding, and dissemination. Throughout, we emphasize the importance of conducting research within the school context, which is consistent with the important influence of ecological systems articulated by Conoley, Powers, and Gutkin (2020), and reflects the hallmark of school psychology scholarship as an applied science. (PsycInfo Database Record (c) 2021 APA, all rights reserved).In this special issue, Conoley et al. (2020) repeat the call for a paradigm shift in school psychology graduate education from the individual level to the system level and from secondary and tertiary intervention to primary prevention and implementation science to optimize environments for children’s overall health and success. This article describes how school psychology training, as organized by professional standards of practice and credentialing, has evolved to its current status as a recognized specialty of practice within psychology. A review of the history of the accreditation and approval of school psychology programs, as well as the current status of competencies within these standards and procedures are presented. In addition, school psychology as a distinct specialty; various certifications, credentials, and licensure; professional identities; and recent developments in technology, telehealth, and cross-state credentialing are examined. The article includes a summary of how competencies are reflected in the most recent revisions of American Psychological Association accreditation, National Association of School Psychologists approval standards, and credentialing organizations such as Association of State and Provincial Psychology Boards. Finally, we conclude with the assertion that development and adoption of these standards, competencies and professional recognition certifications, which are informed by the current zeitgeist in both health and education more broadly, might propel school psychology to fulfill the promise not yet achieved as outlined by Conoley and colleagues (2020). (PsycInfo Database Record (c) 2021 APA, all rights reserved).Over the past 75 years, the history of Division 16 (School Psychology) has been integral to the science and practice of school psychology. As a constituent body of the American Psychological Association (APA), the division has advocated for role definitions and professional boundaries within APA and has represented the specialty of school psychology within the larger community of psychology. Since the convening of school psychology’s Thayer Conference in 1955, the division has remained steadfastly committed to promoting the well-being of children. Toward this end, Division 16 has negotiated entry level debates between APA and the broad specialty of school psychology, sustained partnerships within and among APA and other organizations representing school mental health, elevated the place of technology in the profession of school psychology, and promoted the central importance of cultural competence and diversity within the discipline. The past contributions of Division 16 shape the future of the profession and the division in ways that are consistent with and add to Conoley, Power, and Gutkin’s (2020) recommendations for strengthening school psychology’s contributions to psychological health promotion and risk reduction in schools. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The purpose of this article was to historically review the field of school psychology for the 75th Anniversary of the founding of the Division of School Psychology (DSP) of the APA. Past and present proactive school psychology was evaluated and recommendations for the future were offered in light of historic APA DSP goals. Since its inception, the DSP has worked with APA to protect and expand school psychology as a foundational service area within health service psychology. This article examines the challenges in the field, highlights current issues, and calls for a proactive and transformational future. The article concludes with suggestions from history to adopt current approaches to emulate the transformative vision of proactive school psychology. (PsycInfo Database Record (c) 2021 APA, all rights reserved).We take a look back to 1995 when Conoley and Gutkin shared their vision for an adult-focused practice of school psychology with a primary focus on developing health-promoting systems for schoolage children. We then look to the present to what has happened and not happened to substantiate their vision. We found very encouraging developments and continuing challenges in the research targets and practice roles of school psychologists. There is no shortage of evidence-based strategies to improve the school experience of all children. The opportunities offered by, for example, the Multi-Tiered Systems of Support paradigm are promising, but it is unclear whether school psychologists are assuming leadership roles in this work. Furthermore, incorporating postdoctoral specialties is a promising role expansion for school psychologists, but most of the specialties keep the psychologists’ focus on individual child assessment and treatment. School psychology is a very large professional tent with room for many approaches to preventing childhood disorders and promoting behavioral and academic success. Graduate education and current practice seem to reflect the traditional test and place roles for psychologists that Conoley and Gutkin hoped to expand beyond 25 years ago. Research efforts and national organization supports are hopeful, however, for a reimagined practice of psychology that makes use of the powerful ecosystems that affect children’s well-being. Much work is yet to be done. (PsycInfo Database Record (c) 2021 APA, all rights reserved).This Special Issue celebrates the 75th anniversary of the formation of the Division of School Psychology of the American Psychological Association. As part of this milestone celebration, we envisioned a field that could be changed by transcending the past, excelling in the present, and transforming the future. We identified a seminal article written by Conoley and Gutkin (1995) that advocated for the implementation of a systemic, prevention-oriented, ecological framework that would allow school psychology to realize its promise. Conoley, Powers, and Gutkin (2020) provided a synopsis of progress and stagnation in a new paper that served as the nexus from which invited authors were asked to respond, each representing a different aspect of school psychology practice, science, and training. In light of the division anniversary, authors described the historical context of their domain, reflected on the present, and shared recommendations for the future of school psychology. Collectively these contributions discussed school psychology’s achievement to date, identify its shortfalls, and offer actionable suggestions for future school psychologists. Transformation is critical now more than ever in light of current health and world concerns and school psychology training and practice issues related to social justice and psychological and educational change. School psychologists are called to become proactive agents of change if we are to help heal our fractured and wounded world. (PsycInfo Database Record (c) 2021 APA, all rights reserved).With many employees returning to work after lockdowns and quarantines in the current COVID-19 pandemic, research that seeks to identify effective ways to help them regain focus at work is warranted. However, the small body of applied psychology literature on large-scale disruptive events has paid insufficient attention to this important topic. Further, different from acute events (e.g., disasters), the ongoing pandemic poses an additional challenge for organizations as they seek to effectively protect employees’ job engagement from health and safety threats in the workplace. To address these gaps, we drew from job reattachment research and investigated it as an important antecedent of job engagement for employees returning to work. Moreover, we incorporated leader safety commitment as a moderator that can strengthen the effectiveness of job reattachment in enhancing job engagement. We further linked engagement to work withdrawal, use of personal protective equipment (e.g., wearing a mask), and task performance to underscore the downstream implications of job reattachment. To test our research model, we collected multiwave, multisource data from the original epicenter of the COVID-19 pandemic-Wuhan, China-where many employees were returning to work. The results provide strong support for our model. In addition to extending research on large-scale disruptive events, the current study has important implications for organizations and employees in the COVID-19 pandemic. (PsycInfo Database Record (c) 2021 APA, all rights reserved).It is impossible to write this editorial without recognizing that we are living in challenging times. Unprecedented changes in how, when, where, and with whom we work have occurred in response to the COVID-19 pandemic. In addition to the threat to human life, the pandemic is expected to increase poverty and deepen preexisting inequalities for vulnerable groups such as women (United Nations, 2020) and individuals living in poorer countries (United Nations Development Programme, 2020). In the United States, the pandemic has disproportionately negatively affected racial and ethnic minority group members (https//www.cdc.gov/coronavirus/2019-ncov/community/health-equity/race-ethnicity.html). For example, in the United States infection and mortality rates are especially high among African Americans (Yancy, 2020). These sobering realities, along with the recent deaths of George Floyd, Ahmaud Arbery, and Breonna Taylor, and so many others, are vivid and wrenching reminders of longstanding social injustice and systematic racism, both in the United States and around the globe. When preparing my candidate statement and vision for the journal, a global pandemic and widespread social protest were the furthest thing from my mind. However, several aspects of my vision for JAP are highly relevant to the current context. This includes increasing representation and supporting diversity, as well as improving the translation of our science for the public good. Other elements of my vision for the journal include enhancing the review process and promoting open science. (PsycInfo Database Record (c) 2021 APA, all rights reserved).In a typical endowment effect experiment, individuals state a higher willingness-to-accept to sell an object than a willingness-to-pay to obtain the object. The leading explanation for the endowment effect is loss aversion for the object. An alternative explanation is based on a buy-sell discrepancy, according to which people price the object in a strategic way. Disentangling these two explanations is the goal of this research. To this end, we introduce a third condition, in which participants receive an object and are asked how much they are willing to pay to keep it (Pay-to-Keep). Comparing the three conditions we find no evidence for loss aversion in the endowment effect setting. We found support for the buy-sell strategy mechanism. Our results have important implications for the understanding of buyer and seller behaviors, subjective value, and elicitation methods. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Does aging increase the reliance on central attention to carry out tasks, even when those tasks do not need it? To test the hypothesis of over-reliance on central attention (ORCA), we examined the ability of older adults to entirely bypass ideomotor-compatible (IM) tasks. IM tasks operate automatically for younger adults The perception of an IM stimulus (e.g., a left-pointing arrow) directly activates the associated response code (e.g., pressing the left key). In a psychological refractory period (PRP) procedure, younger and older adults performed a slow auditory-vocal Task 1 paired with a fast visual-manual Task 2 that was either IM or non-IM. Task-2 compatibility (IM vs. non-IM) was manipulated as a between-subjects factor (Experiment 1) and as a within-subjects factor (Experiment 2). Both experiments yielded the counterintuitive finding of larger age differences in dual-task performance when Task 2 was easy (i.e., IM) than when it was difficult (i.e., non-IM), as evidenced by old/young ratio analyses and Brinley plots. Relatedly, whereas younger adults routinely bypassed the bottleneck with an IM Task 2 (as evidenced by a small PRP effect and a high rate of response reversals), older adults did not. The present findings cannot easily be explained by the hypotheses of generalized cognitive slowing and of specific processing deficits but support the ORCA hypothesis. As cognitive decline sets in, older adults begin to try harder This extra application of central attention compensates for cognitive decline but can result in applying attention when it is not needed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Reports an error in „Uncertainty and predictiveness modulate attention in human predictive learning” by Chang-Mao Chao, Anthony McGregor and David J. Sanderson (Journal of Experimental Psychology General, Advanced Online Publication, Nov 30, 2020, np). In the article, formatting for UK Research Councils funding was omitted. The author note and copyright line now reflect the standard acknowledgment of and formatting for the funding received for this article. All versions of this article have been corrected. (The following abstract of the original article appeared in record 2020-88205-001.) Attention determines which cues receive processing and are learned about. Learning, however, leads to attentional biases. In the study of animal learning, in some circumstances, cues that have been previously predictive of their consequences are subsequently learned about more than are nonpredictive cues, suggesting that they receive more attention. In other circumstances, cues that have previously led to uncertain consequen affects attention; however, the precise nature of the effect on attention depends on the level of task complexity, which reflects a potential switch between exploration and exploitation of cues. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Overgeneral autobiographical memory (OGM) refers to the tendency toward increased general memory and reduced specific memory recall, observed in various psychiatric disorders. Previous studies have suggested that inhibitory processes involved in resolving competition between competing memories may reduce memory specificity via retrieval-induced forgetting (RIF). However, it remains unclear whether the repeated retrieval of general memories can induce forgetting of specific memories. We adapted the RIF paradigm to address this question across three experiments. Participants first generated specific memories in response to positively and negatively valenced cue words. They then generated and repeatedly retrieved general memories for half of the cue words. Recall for all of the original specific memories was later tested. Experiment 1 showed that the retrieval practice of general memories reduced the recall of associated specific memories, regardless of cue valence. Experiment 2 demonstrated that this forgetting effect was cue independent, occurring even when novel retrieval cues were used on the final test. Experiment 3 suggested that this effect was competition dependent, finding a greater RIF effect following practice of general memories (high competition) than following a cue-color association task (low competition). These results suggest that repeated retrieval of general memories suppressed specific memory representations through RIF. These findings are discussed in relation to hierarchical models of autobiographical memory, mechanisms that maintain overgeneral memory tendencies, and the role of retrieval in shaping autobiographical memory. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Self-agency is a crucial aspect of self-awareness. It is underresearched given the phenomenon’s subjectivity and difficulty of study. It is particularly underresearched comparatively, given that animals cannot receive agency instructions or make agency declarations. Accordingly, we developed a distinctively new self-agency paradigm. Humans and rhesus macaques learned event categories differentiated by whether the participant’s volitional response controlled a screen launch. They learned by trial and error after minimal instructions with no agency orientation (humans) or no instructions (monkeys). After learning, humans’ verbalized category descriptions were coded for self-agency attributions. Across three experiments, humans’ agency attributions qualitatively improved discrimination performance-participants not invoking self-agency rarely exceeded chance performance. It also produced a diagnostic latency profile classification accuracy depended heavily on the temporal relationship between the button-press and the launch, but only for those invoking agency. In our last experiment, monkeys performed the launch task. Their performance and latency profiles mirrored that of humans. Thus, self-agency can be self-discovered as a frame organizing discrimination. And it may be used as a discrimination cue by some nonhuman animals as well. (PsycInfo Database Record (c) 2021 APA, all rights reserved).This editorial describes the rationale behind changing this journal’s title beginning in 2022. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The reminiscence bump phenomenon is well established adults in the second half of life remember more events from their youth than from other periods. Almost no research has focused, however, on the adaptive value of the reminiscence bump for adult well-being. Grounded in a life story approach, this research examined whether perceiving that one had control over events from the bump period (compared with other past periods and also one’s present life) was related to current life satisfaction. We also investigated whether chronological age moderated these associations. Participants (N = 470; 49-90 years; 59% women) were part of the European Study on Adult Well-being. They briefly reported up to 15 personally significant events from across their entire life. They indicated age at occurrence and rated their perceived control for each reported event. Well-being was assessed with a standard measure of current life satisfaction. Perceived control over the present and covariates including memory valence and current circumstances (i.e., financial security, social living arrangement, number of medications, and mental health) were also measured. Findings indicate that greater perceived control over reminiscence bump events, but not other past events, predicted current life satisfaction in adults in late midlife (i.e., ages 49-60). In contrast, greater present-focused perceived control was associated with life satisfaction in those 62 years and older. The findings are discussed in the context of the life story account of the reminiscence bump. Understanding the adaptive value of recalling one’s personal past may require attention to individuals’ current life phase. (PsycInfo Database Record (c) 2021 APA, all rights reserved).To what extent self-perceptions of aging and their correlates in later life may be gendered remains relatively unexplored. In particular, little is known about how changes in the health and spousal relationship quality over time contribute to self-perceptions of aging among married men and women. To clarify these links, we analyzed panel data from the Health and Retirement Study (2008-2016) on married individuals aged 65 years and older (N = 2,623) using within-between random effects models. Findings showed no gender difference in self-perceptions of aging at baseline and in the rate of change, and poorer health and spousal relationship quality were generally associated with less positive self-perceptions of aging. However, men and women differed in how within-person changes in health and spousal relationship quality were associated with their self-perceptions of aging. Increases in spousal strain and chronic conditions were associated with less positive self-perceptions of aging on that wave for men, whereas increases in functional limitations were associated with less positive self-perceptions of aging on that wave for women. Finally, a person-mean of spousal strain had a moderating effect for men, such that men with more overall spousal strain reported less positive self-perceptions of aging across a range of chronic conditions, compared to the men with less overall spousal strain. Findings highlight the intersection of social resources, health, and self-perceptions of aging, suggesting that gender differences in older adults’ self-perceptions of aging are contextualized by different behaviors and social experiences among married men and women. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Sexual harassment is pervasive and has adverse effects on its victims, yet perceiving sexual harassment is wrought with ambiguity, making harassment difficult to identify and understand. Eleven preregistered, multimethod experiments (total N = 4,065 participants) investigated the nature of perceiving sexual harassment by testing whether perceptions of sexual harassment and its impact are facilitated when harassing behaviors target those who fit with the prototype of women (e.g., those who have feminine features, interests, and characteristics) relative to those who fit less well with this prototype. Studies A1-A5 demonstrate that participants’ mental representation of sexual harassment targets overlapped with the prototypes of women as assessed through participant-generated drawings, face selection tasks, reverse correlation, and self-report measures. In Studies B1-B4, participants were less likely to label incidents as sexual harassment when they targeted nonprototypical women compared with prototypical women. In Studies C1 and C2, participants perceived sexual harassment claims to be less credible and the harassment itself to be less psychologically harmful when the victims were nonprototypical women rather than prototypical women. This research offers theoretical and methodological advances to the study of sexual harassment through social cognition and prototypicality perspectives, and it has implications for harassment reporting and litigation as well as the realization of fundamental civil rights. For materials, data, and preregistrations of all studies, see https//osf.io/xehu9/. (PsycInfo Database Record (c) 2021 APA, all rights reserved).People seek to detect who facilitates and who impedes their goal pursuit. The resulting relevance appraisals of opportunity and threat, respectively, can strongly shape subsequent social judgment and behavior. However, important questions about the nature of relevance appraisals remain unanswered Are relevance appraisals unidimensional or multidimensional? Are people evaluated as generally posing opportunities and/or threats, or as dynamically relevant depending on perceiver goals? We test two hypotheses. First, we propose that opportunity and threat are appraised independently, rather than as endpoints of a single dimension. If so, then others can be evaluated as (a) facilitating a goal, (b) impeding a goal, (c) both facilitating and impeding a goal, or (d) neither facilitating nor impeding a goal. Second, we hypothesize that relevance appraisals shift dynamically with perceiver goals. For example, a single person may be appraised as facilitating one’s mate-seeking goal, but as neither facilitating nor impeding one’s self-protection goal. In two studies, participants rated the extent to which a variety of targets (e.g., a doctor, a 5-year-old child) pose threats and opportunities to different goals. Confirmatory factor analyses support both hypotheses. We also explore relationships between the Relevance Appraisal Matrix and the stereotype content (Fiske et al., 2002) and ABC (Koch et al., 2016) models of stereotypes, finding evidence that relevance appraisals are distinct from stereotypes of group attributes. In sum, we provide a framework for understanding the structure of relevance appraisals A central and consequential, yet dynamic and relatively understudied, aspect of social cognition. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Employees exert emotional effort in order to perform their work effectively, albeit to varying degrees based on their occupation. These emotional job demands (EJDs) affect employees’ well-being, yet evidence is mixed as to whether these effects are positive or negative. One limiting factor in extant studies is that they investigated short-term effects or cross-sectional relationships between EJDs (usually assessed at the employee level) and work outcomes. The present study used an accelerated longitudinal design with a 10-year timespan of data (effectively covering the whole working lifespan) to test the effects of EJDs at the occupational level on long-term trajectories of well-being. Drawing on the model of strengths and vulnerabilities integration (SAVI) from the lifespan psychology literature, we tested three competing effects an experience effect (EJDs predict increased well-being), a vulnerability effect (EJDs predict diminished well-being), and an overload effect (a non-linear relationship in which very high levels lead to more unfavorable trajectories). Using data of N = 2,478 working adults in Germany drawn from the Socioeconomic Panel Study (SOEP), in tandem with data on EJDs from the Occupational Information Network (O*NET), we found an overload effect of EJDs on trajectories of positive affect and job satisfaction. However, EJDs did not influence trajectories of negative affect. We discuss the implications of our findings for theory and practice. (PsycInfo Database Record (c) 2021 APA, all rights reserved).We examine how team members respond to the inclusion of new members’ physical attractiveness and sex. Drawing on Social Exchange Theory, we argue and show that incumbent team members engage in three behaviors (mimicry, ingratiation, and challenging) in response to the inclusion of more or less attractive male or female members in their team. Using a multilevel experimental design, we show that existing team members mimic newcomers who are higher on physical attractiveness and that the effect is more pronounced when there is a sex match (i.e., existing males mimic new males more). Furthermore, they ingratiate toward the physically attractive newcomers who are also committed to the task. In addition, we find that existing team members challenge physically attractive females who are committed to the task. Our findings suggest that the basic combinations of primary cues of newcomers’ characteristics affect intrateam behaviors and produce different outcomes across sexes for attractiveness. By shifting the attention to the effect that newcomers have on team behaviors, the study provides novel insights for scholars that help move the discussion of team membership changes beyond the traditional accounts of new member socialization and team effectiveness. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Posttraumatic stress disorder (PTSD) has a specified precipitant (i.e., trauma), and thus, is particularly well-suited to examine risk and maintenance factors for the development of the disorder. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) alternative model of personality disorder (AMPD) is based, in part, on a dimensional trait model; previous research suggests that personality traits are related to PTSD symptoms. To date, there is little research examining this model with regard to PTSD symptoms, and such research could elucidate new strategies for identification and prevention. The present study investigates associations between AMPD traits and PTSD symptoms in a cross-sectional high-risk sample (N = 490; 100% female; 97.8% African American) and in a prospective, longitudinal sample of Level 1 trauma center patients (N = 185; 46.8% female; 72.5% African American). The Personality Inventory for DSM-5 Brief Form domains were significantly associated with PTSD total symptom severity and symptom clusters across both self-report and clinical interview measures. Personality Inventory for DSM-5 Negative Affectivity and Psychoticism emerged as significant predictors of concurrent PTSD. When prospectively predicting PTSD symptoms in the longitudinal cohort, Negative Affectivity and Psychoticism were significant predictors of PTSD symptom severity. These findings indicate how the DSM-5 AMPD pathological traits are associated with risk for stress-related disorders cross-sectionally and prospectively. (PsycInfo Database Record (c) 2021 APA, all rights reserved).A central question in psychological science concerns whether psychological constructs are best conceptualized as dimensional or consist of one or more categories. The present study uses contemporary taxometric procedures to examine the latent structure of suicidal thoughts, with implications for how suicidal thoughts and behavior (STB) ought to be conceptualized, assessed, measured, and managed. Three nonredundant taxometric procedures (MAMBAC, MAXEIG, and L-Mode) were performed on various sets of indicators, and analyses were replicated across two large samples that included large numbers of individuals reporting current and recent STB. Results provide further evidence that the latent structure of suicidal thoughts is best understood as dimensional. However, inconsistent findings across studies and the relatively small number of taxometric studies conducted to date both suggest that it is premature to draw clear or definitive conclusions about the latent structure of STB being dimensional or categorical based on taxometric evidence. We report a meta-analysis of the current literature which evidences this ambiguity. We provide a detailed, critical discussion of the STB taxometric literature and outline key directions for future taxometric studies in this area, particularly how taxometric analysis relates to testing „ideation to action” theoretical models, which hypothesize that the development of suicidal ideation and the progression from suicide desire to attempting suicide are distinct processes with distinct explanations/mechanisms. It remains entirely possible that qualitatively distinct types of STB (e.g., representing ideation vs. action) or populations have different latent structures indicating different levels of risk. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Animals need to adjust their decision-making strategies to the ecological challenges of their environment. Variation in ecological unpredictability and harshness thus seem to affect their decisions in the wild. In our study, we combine methods from human life history theory and previous comparative work with chimpanzees to investigate whether current variability in ecological factors such as reward unpredictability and harshness affect chimpanzees’ decision-making strategies in two value-based scenarios. We presented chimpanzees with choices varying in the probability of obtaining food rewards (risk-choice task) and in their temporal availability (temporal discounting task). These scenarios were preceded by different sets of priming phases mimicking variability in resource unpredictability (predictable or unpredictable rewards) and harshness (abundant or scarce rewards). In addition, we implemented a social manipulation to explore whether variations in unpredictable gains and losses affected chimpanzees’ performance in both tasks. We found that chimpanzees were only affected by the social manipulation in the risk-choice scenario. Specifically, after a period of constant food losses chimpanzees became less risk prone. We discuss how different types of negative experiences affect chimpanzees’ decisions. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Previous work with corvids such as scrub jays (Aphelocoma californica) and ravens (Corvus corax) suggests that many social corvids alter their caching behavior when observed by conspecifics to protect their caches. We examined whether the Clark’s nutcracker (Nucifraga columbiana), an asocial corvid, can utilize a barrier to conceal its caching activities from a conspecific observer. Nutcrackers were allowed to cache nuts in a visible or concealed location in either the presence or absence of an observer. Nutcrackers were also given experience of having their caches pilfered. The nutcrackers cached significantly more nuts in the concealed compared to a visible location when observed. Importantly, nutcrackers also recovered a larger percentage of their nuts 24 hr later from a visible cache location but when the observer was no longer present. The results extend recent work suggesting that relatively nonsocial corvids, similar to their more social relatives, also engage in multiple forms of cache protection. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Protein adsorption onto nanomaterial surfaces is important for various nanobiotechnology applications such as biosensors and drug delivery. Within this scope, there is growing interest to develop alumina- and silica-based nanomaterial vaccine adjuvants and an outstanding need to compare protein adsorption onto alumina- and silica-based nanomaterial surfaces. Herein, using alumina- and silica-coated arrays of silver nanodisks with plasmonic properties, we conducted localized surface plasmon resonance (LSPR) experiments to evaluate real-time adsorption of bovine serum albumin (BSA) protein onto alumina and silica surfaces. BSA monomers and oligomers were prepared in different water-ethanol mixtures and both adsorbing species consistently showed quicker adsorption kinetics and more extensive adsorption-related spreading on alumina surfaces as compared to on silica surfaces. We rationalized these experimental observations in terms of the electrostatic forces governing protein-surface interactions on the two nanomaterial surfaces and the results support that more rigidly attached BSA protein-based coatings can be formed on alumina-based nanomaterial surfaces. Collectively, the findings in this study provide fundamental insight into protein-surface interactions at nanomaterial interfaces and can help to guide the development of protein-based coatings for medical and biotechnology applications such as vaccines.Taking advantage of the diversity-oriented synthesis strategy with α,β-unsaturated carbonyl compounds, we have successfully established the DNA-compatible transformations for various heterocyclic scaffolds. The ring-closure reactions for pyrrole, pyrrolidine, pyrazole, pyrazoline, isoxazoline, pyridine, piperidine, cyclohexenone, and 5,8-dihydroimidazo[1,2-a]pyrimidine were elegantly demonstrated in a DNA-compatible format. These efforts paved the way for preparing DNA-encoded libraries with more extensive chemical space.Bioaerosols, including infectious diseases such as COVID-19, are a continuous threat to global public safety. Despite their importance, the development of a practical, real-time means of monitoring bioaerosols has remained elusive. Here, we present a novel, simple, and highly efficient means of obtaining enriched bioaerosol samples. Aerosols are collected into a thin and stable liquid film by the unique interaction of a superhydrophilic surface and a continuous two-phase centrifugal flow. We demonstrate that this method can provide a concentration enhancement ratio of ∼2.4 × 106 with a collection efficiency of ∼99.9% and an aerosol-into-liquid transfer rate of ∼95.9% at 500 nm particle size (smaller than a single bacterium). This transfer is effective in both laboratory and external ambient environments. The system has a low limit of detection of less then 50 CFU/m3air using a straightforward bioluminescence-based technique and shows significant potential for air monitoring in occupational and public-health applications.We describe here the facile construction of sterically hindered tertiary alkyl ethers and thioethers via the Zn(OTf)2-catalyzed coupling of alcohols/phenols with unactivated tertiary alkyl bromides and the Cu(OTf)2-catalyzed thiolation of unactivated tertiary alkyl oxalates with thiols. The present protocol represents one of the most effective unactivated tertiary C(sp3)-heteroatom bond-forming conditions via readily accessible Lewis acid catalysis that is surprisingly less developed.A family of novel compounds with planar tetracoordinate silicon (ptSi) supported by B-heterocyclic carbenes (BHCs) have been theoretically investigated. The lowest energy molecules (a3, b3, and c3) with single ptSi are a triplet. We further designed 1D and 2D compounds with multi-ptSi atoms by condensation of a3 along latitudinal (m) and longitudinal (n) directions. The lowest energy 1D compounds prefer to be zigzag conformation along the m direction. The lowest energy 2D compounds (m,n) (m ≥ n) are zigzag conformation along both m and n directions. The total spin quantum number (S) of the lowest energy compounds with ptSi is equal to the number of ptSi. Thus, the compounds with ptSi stabilized by BHCs are magnetic. The singly occupied molecular orbitals (SOMOs) of such compounds are mainly the linear combination of the 3p orbitals of ptSi, indicating that the magnetism of the compounds originates from ptSi.The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has been precluded by human host toxicities and suppression of immune responses. We recently described resorcylate aminopyrazoles (RAPs) as the first class of Hsp90 inhibitors capable of discriminating between fungal (Cryptococcus neoformans, Candida albicans) and human isoforms of Hsp90 in biochemical assays. Here, we report an iterative structure-property optimization toward RAPs capable of inhibiting C. neoformans growth in culture. In addition, we report the first X-ray crystal structures of C. neoformans Hsp90 nucleotide binding domain (NBD), as the apoprotein and in complexes with the non-species-selective Hsp90 inhibitor NVP-AUY922 and three RAPs revealing unique ligand-induced conformational rearrangements, which reaffirm the hypothesis that intrinsic differences in protein flexibility can confer selective inhibition of fungal versus human Hsp90 isoforms.The first asymmetric total synthesis of C(9)-S-(+)-taumycin A is now reported using an approach that targeted both C(9) diastereomers concurrently. To facilitate this work, we called upon the symmetrical nature of a C(5)-C(13) side-chain intermediate and exploited orthogonal protecting groups as a tactic to access both stereoisomers from a single chiral, nonracemic intermediate. In addition to our successful approach, several minor detours that helped refine our strategy and a detailed analysis of 1H NMR data will be discussed. Select compounds included in this work were screened against the NCI60 cell line panel and displayed modest growth inhibition activity.Lactylates are an important group of molecules in the food and cosmetic industries. A series of natural halogenated 1-lactylates, chlorosphaerolactylates (1-4), were recently reported from Sphaerospermopsis sp. LEGE 00249. Here, we identify the cly biosynthetic gene cluster, containing all the necessary functionalities for the biosynthesis of the natural lactylates, based on in silico analyses. Using a combination of stable isotope incorporation experiments and bioinformatic analysis, we propose that dodecanoic acid and pyruvate are the key building blocks in the biosynthesis of 1-4. We additionally report minor analogues of these molecules with varying alkyl chains. This work paves the way to accessing industrially relevant lactylates through pathway engineering.A Ru(II)-catalyzed facile and controllable protocol for C-H alkylation and spirocyclization of 2-arylquinoxalines with maleimides has been achieved under ambient air in high yields. Sequential ortho-C-H activation and C-annulation results in the formation of diverse polyheterocycles containing spiro[indeno[1,2-b]quinoxaline-11,3′-pyrrolidine]-2′,5′-diones, which are of potent interest in medicinal chemistry. Mechanistic investigations suggest a reversible cleavage of the ortho-C-H bond in the turnover-limiting step.The independent gradient model (IGM) is a recent electron density-based computational method that enables to detect and quantify covalent and noncovalent interactions. When applied to large systems, the original version of the technique still relies on promolecular electron densities given by the sum of spherically averaged atomic electron distributions, which leads to approximate evaluations of the inter- and intramolecular interactions occurring in systems of biological interest. To overcome this drawback and perform IGM analyses based on quantum mechanically rigorous electron densities also for macromolecular systems, we coupled the IGM approach with the recently constructed libraries of extremely localized molecular orbitals (ELMOs) that allow fast and reliable reconstructions of polypeptide and protein electron densities. The validation tests performed on small polypeptides and peptide dimers have shown that the novel IGM-ELMO strategy provides results that are systematically closer to the fully quantum mechanical ones and outperforms the IGM method based on the crude promolecular approximation, but still keeping a quite low computational cost. The results of the test calculations carried out on proteins have also confirmed the trends observed for the IGM analyses conducted on small systems. This makes us envisage the future application of the novel IGM-ELMO approach to unravel complicated noncovalent interaction networks (e.g., in protein-protein contacts) or to rationally design new drugs through molecular docking calculations and virtual high-throughput screenings.The prevalence of intrinsically disordered proteins (IDPs) and protein regions in structural biology has prompted the recent development of molecular dynamics (MD) force fields for the more realistic representations of such systems. Using experimental nuclear magnetic resonance backbone scalar 3J-coupling constants of the intrinsically disordered proteins α-synuclein and amyloid-β in their native aqueous environment as a metric, we compare the performance of four recent MD force fields, namely, AMBER ff14SB, CHARMM C36m, AMBER ff99SB-disp, and AMBER ff99SBnmr2, by partitioning the polypeptides into an overlapping series of heptapeptides for which a cumulative total of 276 μs MD simulations were performed. The results show substantial differences between the different force fields at the individual residue level. Except for ff99SBnmr2, the force fields systematically underestimate the scalar 3J(HN,Hα)-couplings due to an underrepresentation of β-conformations and an overrepresentation of either α- or PPII conformations. The study demonstrates that the incorporation of coil library information in modern MD force fields, as shown here for ff99SBnmr2, provides substantially improved performance and more realistic sampling of the local backbone dihedral angles of IDPs as reflected by the good accuracy of the computed scalar 3J(HN,Hα)-couplings with less than 0.5 Hz error. Such force fields will enable a better understanding of how structural dynamics and thermodynamics influence the IDP function. Although the methodology based on heptapeptides used here does not allow the assessment of potential intramolecular long-range interactions, its computational affordability permits well-converged simulations that can be easily parallelized. This should make the quantitative validation of intrinsic disorder observed in MD simulations of polypeptides with experimental scalar J-couplings widely applicable.A key step in gas-phase polycyclic aromatic hydrocarbon (PAH) formation involves the addition of acetylene (or other alkyne) to σ-type aromatic radicals, with successive additions yielding more complex PAHs. A similar process can happen for N-containing aromatics. In cold diffuse environments, such as the interstellar medium, rates of radical addition may be enhanced when the σ-type radical is charged. This paper investigates the gas-phase ion-molecule reactions of acetylene with nine aromatic distonic σ-type radical cations derived from pyridinium (Pyr), anilinium (Anl), and benzonitrilium (Bzn) ions. Three isomers are studied in each case (radical sites at the ortho, meta, and para positions). Using a room temperature ion trap, second-order rate coefficients, product branching ratios, and reaction efficiencies are measured. The rate coefficients increase from para to ortho positions. The second-order rate coefficients can be sorted into three groups low, between 1 and 3 × 10-12 cm3 molecule-1 s-1 (3Anl and 4Anl); intermediate, between 5 and 15 × 10-12 cm3 molecule-1 s-1 (2Bzn, 3Bzn, and 4Bzn); and high, between 8 and 31 × 10-11 cm3 molecule-1 s-1 (2Anl, 2Pyr, 3Pyr, and 4Pyr); and 2Anl is the only radical cation with a rate coefficient distinctly different from its isomers.