The effectiveness of each method in removing the offsets was shown to reduce with increased echo time, decreased signal intensity and reduced overlap in coil sensitivity profiles. Quantitative susceptibility values and how they change with echo time were found to be method specific. Phase offset correction methods based on single echo time data have a tendency to produce more accurate and less noisy quantitative susceptibility maps in comparison with methods employing multiple echo time data.

There is a clinical interest in identifying normal appearing white matter (NAWM) areas in brain T2-weighted (T

W) MRI scans in multiple sclerosis (MS) subjects. These areas are susceptible to disease development and areas need to be studied in order to find potential associations between texture feature changes and disease progression.

The subjects investigated had a first demyelinating event (Clinically Isolated Syndrome-CIS) at baseline (Time

), and the NAWM

(i.e. NAWM at Time

) of the brain tissue was subsequently converted to demyelinating plaques (as evaluated in a follow up MRI at Time

). 38 untreated subjects that had developed a CIS, had brain MRI scans within an interval of 6-12months (Time

at follow-up). An experienced MS neurologist manually delineated the demyelinating lesions at Time

(L

) and at Time

(L

). Areas in the Time

MRI scans, where new lesions had been developed, were mapped back to their corresponding NAWM areas on the Time

MR scans (ROIS

). In addition, contralateral ROIs of similar size and shape were segmented on the same images at Time

(ROIS

) to form an intra-subject control group. Following that, texture features were extracted from all prescribed areas and MS lesions.

Texture features were used as input into Support Vector Machine (SVM) models to differentiate between the following NAWM

vs ROIS

, NAWM

vs NAWM

, NAWM

vs L

, NAWM

vs L

, ROIS

vs L

, ROIS

vs L

and ROIS

vs ROIS

, where the corresponding % correct classifications scores were 89%, 95%, 98%, 92%, 85%, 90% and 65% respectively.

Texture features may provide complementary information for following up the development and progression of MS disease. Future work will investigate the proposed method on more subjects.

Texture features may provide complementary information for following up the development and progression of MS disease. Future work will investigate the proposed method on more subjects.

To compare the imaging characteristics of the volumetric-interpolated breath-hold examination (VIBE) using compressed-sensing (CS) acceleration (CS-VIBE) with the conventional sequence relying on parallel imaging to assess the potential use of CS-VIBE as a functional imaging technique for upper abdominal haemodynamics.

Patients (30 men, 27 women) suspected of having a hepatic disease underwent magnetic resonance imaging (MRI) of the liver, including a dynamic contrast-enhanced study. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid was used as the contrast agent. MRI data of two multi-phase breath-hold exams were used for intra-individual comparisons. The VIBE and CS-VIBE were performed on different days. Image quality in both sequences was qualitatively assessed by three experienced radiologists. Moreover, the contrast ratio (CR) of the aorta, portal vein, liver and pancreas to muscle tissue were measured as a quantitative assessment. For the CS-VIBE, a five-phase time-intensity curve (TIC) wation speed for dynamic MRI can be adequately addressed, we believe that CS-VIBE functional images with high-contrast haemodynamics will be very useful in clinical practise.

Compared with the conventional VIBE, the CS-VIBE had significantly higher temporal resolution and higher image contrast. The temporal resolution of the CS-VIBE was sufficient for viewing abdominal haemodynamics. If the remaining limitation of acquisition speed for dynamic MRI can be adequately addressed, we believe that CS-VIBE functional images with high-contrast haemodynamics will be very useful in clinical practise.There is broad consensus that children’s ability to regulate emotion, particularly negative affect, can have enormous implications for the cascading processes underlying social and emotional development. With the burgeoning autonomy of toddlerhood comes a rudimentary understanding of the varieties of emotional experience, and initial awareness that a child’s actions can augment or attenuate the intensity of those experiences. Successful forays into emotion regulation are crucial for healthy psychological development, allowing children to accommodate life’s difficulties by purposefully altering their emotional state (ie, coping) when necessary. By contrast, persistent negative affect in childhood is known to increase the risk for depression by late adolescence.1 Neuroimaging studies in youth and adults have implicated a key circuit in the generation and regulation of negative affect including the amygdala, a subcortical structure that detects emotionally salient information, and the medial prefrontal cortex (mPFC), a cortical region known to exert regulatory influence on the amygdala. Synchronous activation of these regions, reflecting functional transmission of information between them, is conceptually and empirically linked to individual differences in the intensity and purposeful modulation of emotion.2 Furthermore, amygdala reactivity is associated with negative affect in preschoolers,3 whereas emotion-related amygdala-mPFC connectivity may shape the subsequent development of resting (intrinsic) amygdala-mPFC connectivity, particularly in childhood.4.It is heartening to see that our rapid systematic review1 is stimulating others to highlight the needs of particular subsets of vulnerable children and adolescents. We found evidence that loneliness in children and adolescents is associated with increased depression and anxiety symptoms both cross-sectionally and longitudinally. We agree with Dr. Morrissette2 that children and adolescents with social phobia merit additional consideration in the 2019 novel coronavirus disease (COVID-19) pandemic. Speculatively, we suggest that many children and adolescents who did not have social phobia before the pandemic may begin to experience worries about social situations as schools reopen. Furthermore, we hypothesize that a range of mental health symptoms including social phobia are likely to become more obvious as many pupils return to school.In their recent systematic review, Loades et al.1 reported on the effects that social isolation and loneliness may have on children and adolescents during the global 2019 novel coronavirus disease (COVID-19) pandemic, with their findings suggesting associations between social anxiety and loneliness/social isolation. While this is undoubtedly true for many children and adolescents, it is also worth commenting on the subset of children and youths with social phobia for whom a temporary lessening of distress may be observed while schools are closed owing to a lack of exposure to anxiety-provoking situations in the school environment.The impacts of the Adverse Childhood Experiences (ACEs) Study continue to reverberate across medicine, influencing clinical practice, research, and public policy, prompting reexamination of the original ACEs research, and generating a range of new research questions that are critical for understanding health and development across the lifespan.1,2 Within child and adolescent psychiatry, this explosion of interest in childhood trauma and its consequences is generating rich new areas of inquiry how does adversity become biologically embedded in brain structure and functioning? What familial, environmental, and genetic factors influence resilience and risk? How should we update and adapt the original ACEs framework to account for cultural, ethnic, and geographic differences across populations with various exposures during childhood and distinct ways of experiencing and understanding these exposures? What positive experiences during childhood might have equally profound lifelong health impacts? In this issue of the Journal, Salhi et al.3 present findings from a large cross-national survey of parents of young children to examine their hypotheses that particular household exposures, physical discipline, and lack of cognitive stimulation represent adverse experiences associated with specific developmental outcomes in young children. Like much related research emerging in this area, the present study may provoke more new questions than it answers, and the article sharpens our focus to better understand the developmental science of early adversity and its implications for mental health promotion and clinical care.

Centers from Europe and United States have reported an exceedingly high number of children with a severe inflammatory syndrome in the setting of coronavirus disease 2019, which has been termed multisystem inflammatory syndrome in children (MIS-C).

This study aimed to analyze echocardiographic manifestations in MIS-C.

A total of 28 MIS-C, 20 healthy control subjects and 20 classic Kawasaki disease (KD) patients were retrospectively reviewed. The study reviewed echocardiographic parameters in the acute phase of the MIS-C and KD groups, and during the subacute period in the MIS-C group (interval 5.2 ± 3days).

Only 1 case in the MIS-C group (4%) manifested coronary artery dilatation (z score=3.15) in the acute phase, showing resolution during early follow-up. Left ventricular (LV) systolic and diastolic function measured by deformation parameters were worse in patients with MIS-C compared with KD. Moreover, MIS-C patients with myocardial injury were more affected than those without myocardial injury with rteries may be spared in early MIS-C; however, myocardial injury is common. Even preserved EF patients showed subtle changes in myocardial deformation, suggesting subclinical myocardial injury. During an abbreviated follow-up, there was good recovery of systolic function but persistence of diastolic dysfunction and no coronary aneurysms.Our aim was to identify the longitudinal changes in gray matter volume (GMV) and secondary alterations of structural covariance after pontine stroke (PS). Structural MRI and behavioral scores were obtained at 1 week, 1 month, 3 months, 6 months in 11 patients with PS. Twenty healthy subjects underwent the same examination only once. We used voxel-based morphometry and seed-based structural covariance to investigate the altered GMV and structural covariance patterns. Furthermore, the associations between the GMV changes and behavioral scores were assessed. With the progression of the disease, GMV decreased significantly in the bilateral cerebellar posterior lobe (ipsilateral Crus II (CBE Crus II_IL) and contralateral Crus I (CBE Crus I_CL)), which were initially detected at the first month and then continued to decrease during the following 6 months. Based on the CBE Crus II_IL and CBE Crus I_CL as seed regions, structural covariance analysis revealed that there were more positively and negatively correlated brain regions in PS group, mainly distributed in the bilateral prefrontal lobe, parietal lobe, temporal lobe, paralimbic system and cerebellum. In addition, PS group showed more additional correlations between these covariant brain regions, and the changes of GMV in these regions were correlated with behavioral scores related to motor and cognitive functions. These findings indicate that PS could lead to significant GMV atrophy in the bilateral cerebellar posterior lobe at the early stage, accompanied by anomalous structural covariance patterns with more covariant brain regions and additional structural connectivity, which may provide useful information for understanding the neurobiological mechanisms of behavioral recovery after PS.