Adipokine dysregulation may play a role in the development of frailty in heart failure.

Glycemic control is important in order to avoid LDLs increased susceptibility to oxidation in diabetic patients. This study assess the relationship between diabetes control with serum prooxidant-antioxidant balance (PAB), oxidized LDL cholesterol (oxLDLc), homocysteine and vitamin D levels in patients with type 2 diabetes.

This was a cross-sectional study on threegroups including 80 subjects as well (WGC) and poor (PGC) glycemic control and 40 healthy subjects. Presence of nephropathy and retinopathy were determined using IDF criteria. HbA1c level was determined with columnar chromatography using BioSystems kit. Serum PAB, homocysteine, oxLDLc and vitamin D levels were measured by the standard tests.

There was a significant association between PAB with PGC (P< 0.001), diabetic retinopathy (P< 0.01) and nephropathy (P< 0.01) in type 2 diabetic patients. Moreover, the results showed that vitamin D serum levels was significantly lower in PGC patients (P< 0.01), and diabetic patients with retinopathy (P< 0.01). Multiple linear regression analysis revealed that the vitamin D deficiency can predict the HbA1c variations by 77.7% (β=- 0.775) in subjects with type 2 diabetes mellitus (P<0.001).

There was a significant association between prooxidant-antioxidant balance and vitamin D serum levels with diabetic complications.

There was a significant association between prooxidant-antioxidant balance and vitamin D serum levels with diabetic complications.Purpose The purpose of this bibliometric study was to summarize European orthopedic literature produced by EFORT memberships between 2009 and 2019 and to identify the 100 most cited articles, analyzing the characteristics that made them so interesting for the orthopedic scientific world. Method A search of the literature was conducted using Clarivate Analytics Web of Science in the subject category „orthopaedics”; then the results were summarized using Web of Science tools. Results A total of 160.375 articles were found most of these were produced by England. In particular the most prolific institution was the University of London. Analyzing in detail the 100 most cited publications emerged that most of them were review published in journal with high impact factor (Q1). The University of Oxford was the institution with the greatest number of contributions (13%). The most cited topics were osteoarthritis (24%), followed by orthopedic basic science (22%). Biomaterials was the most common topic by ordering the 100 analyzed articles according to „usage count”, a recent indicator of the level of interest in a specific item. Conclusion This bibliometric study can be useful to identify topics of interest for future scientific research and to outline the features that make some publications more interesting than others.

Burnout is a stress-induced occupational related syndrome, characterized by Emotional Exhaustion (EE), feeling of depersonalization (DP) and low sense of professional accomplishment (PA). The aim of this study is to analyse the effectiveness of interventions in decreasing health professionals Burnout as well as work and life-style risk factors. Methods A survey in Medical Oncology Department in the University Hospital of Parma was conducted using the validated Maslach Burnout Inventory (MBI) and two additional questionnaires exploring lifestyle and work factors. An 8-months intervention involved fortnight meetings by facilitators, incorporated elements of reflection, shared experiences and managing emotions. Six months after the end of the intervention a second survey was performed among the participants using MBI and the same questionnaires mentioned above. Results EE resulted the most problematic score in Day Hospital after the 8-month intervention we described a significant decreasing in EE score especiak of Burnout. Our study in Oncology Department shows that specific intervention should be used to prevent and reduce Burnout. Effective personal health care strategies should be incorporated into routine oncology care to prevent and treat Burnout.To date, there is still a lack of unanimity regarding the definition of exacerbation of asthma and COPD and about objective measurements in the currently used criteria. The aim of our study was to conduct a survey among general practitioners (GPs) and pulmonologists regarding the clinical criteria arbitrarily considered as important to start a course of systemic corticoids and/or antibiotics in asthma and COPD. We conducted a survey enrolling 50 general practitioners (GPs) and 50 pulmonologists, that evaluated the clinical criteria arbitrated as essential to start a course of systemic corticosteroids or antibiotics during asthma and/or COPD exacerbations. Our results demonstrated incongruities between GPs and pulmonologist and within the same professional category concerning systemic corticosteroids. Conversely, we showed higher consensus between and within the groups about criteria to prescribe antibiotics.Background The aim of this retrospective study is to evaluate the patient-reported outcome after immediate ADM-assisted implant- based breast reconstruction. Material and Methods Patients underwent breast reconstruction from 2015 to 2019 have been retrospectively divided into group A (partial subpectoral implant and ADM and group B (expander/implant). For each patient we evaluated retrospectively postoperative complications and patients’ satisfaction. Results 26 patients from the case group and 40 from the control group completed the BREAST-Q. The incidence of complications in the cases was 18.4%, while in the control group was 20.4%. We found no statistical difference in most of the domains and in the mean score of the questionnaire (mean score cases=69.0±14.4 vs controls=68.4±15.7; p=0.888). A significant difference results only in the domains Q2a and Q2b, sensation of rippling. Conclusions. The use of ADM in one-stage reconstruction allows to perform breast reconstruction in only one surgery, with similar complication rates and patient satisfaction.We report the case of a 15-year-old boy who developed eosinophilic esophagitis (EoE) during cow’s milk oral immunotherapy (CM-OIT). In order to not completely invalidate OIT benefits, baked milk-containing foods were allowed instead of a strict CM-free diet. However, histological remission of EoE was reached only after a strict cow’s milk-free diet, not associated to pharmacological treatment. Nevertheless, given the limited data on real incidence of food OIT related EoE and potential beneficial treatment for this condition, we highlight the need of prospective studies aimed to evaluate if a strict CM free diet in OIT related EoE is always necessary to obtain remission of the disease or similarly to CM EoE, baked milk-containing foods” diet could be abeneficial treatment also in these patients.

This study aims to quantify abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) using T2-weighted magnetic resonance imaging (MRI), and assess the extent of its concordance with VAT surface-area measured by a state-of-the-art segmental multi-frequency bioelectrical impedance analysis (BIA) device. A comparison between manual and semi-automated segmentation was conducted. Further, abdominal VAT and SAT sex-based comparison in healthy Arab adults was piloted.

A cross-sectional design was followed to recruit subjects. Abdominal VAT and SAT were determined on T2-weighted MRI manually and semi-automatically. Body composition was assessed using a BIA machine. Statistical differences between the abdominal VAT areas defined by BIA, manual, and semi-automated MRI were compared. Correlation between all methods was assessed, and statistical differences between sex abdominal VAT/SAT defined areas were compared.

A total of 165 abdominal T2-weighted MR images taken for 55 overweight/obese ada feasible and convenient assessment tool for the visceral adiposity in obese subjects.Emergent pathogen as Purpureocillium lilacinum are becoming cause of morbidity and mortality in our population, especially in immunocompromised patients. We describe a case of hyalohyphomycosis in a diabetic man under systemic steroid treatment for a bullous pemphigoid. Treatment with different antimycotic drugs were ineffective and infection spread diffusely, leading to deterioration of general conditions and ultimately death. The aim of this article is to increase awareness of clinicians about this uncommon, but frequently fatal refractory mycotic infection.

Estimation of age, stature, sex, and ancestry contributes to the establishment of the biological profile of the deceased in forensic examinations. Assessment of the body weight aids in the approximation of the overall body size of the individual which may help in the forensic identification process. In clinical examinations, body weight assessment assumes importance in cases where body weight measurement is a challenging task due to illness and body deformity.

The present research was conducted to estimate the body weight from the percutaneous width of the bones and joints with the help of prediction equations.

The study was carried out on 344 adults (172 Females and 172 Males) aged between 18 and 25 years from the Himachal Pradesh State of North India. Eleven anthropometric measurements including height vertex, mid-arm circumference, humerus bicondylar width, transverse chest breadth, sagittal chest breadth, bi-iliac breadth, handbreadth, femur bicondylar breadth, ankle breadth, foot breadth, and body r regression models show better accuracy than simple linear regression models. The MAPPE was found to be less in the case of multiple linear regression models than the linear ones.

The present investigation concludes that regression models can be used in the estimation of body weight from the percutaneous measurements and joint widths with reasonable accuracy in an Indian population.

The present investigation concludes that regression models can be used in the estimation of body weight from the percutaneous measurements and joint widths with reasonable accuracy in an Indian population..

processing the heterogeneous data on the Italian Covid-19 epidemic by fractal investigation on the trend curve of the ratio between new Covid19 cases/new Sars-Cov-2 tests.

New cases of Covid-19 disease and new tests were calculated from raw data freely available on the Italian governing website. The effectiveness of Italian government Decrees aiming to obtain lock-down was assessed by fractal investigation. Self-similarity parameters of presumed fractal shapes obtained 6 days after each Decree were estimated, when possible. Self-organized criticality was also assessed to check for chaos involvement in disturbing the fractal shapes. Shapes were then compared and were used to estimate the number of new tests for Sars-Cov-2 that Italy would be able to perform.

The full lock-down changed the biocomplexity of the Covid-19 epidemic in Italy. If the biocomplexity of Covid-19 did not change after the lock-down, Italy should have been able to perform at least 25490 tests daily (±8940) on average, while real data show that a larger number of tests were done (p<0.