the four cancerous cell lines. Cyanobacteria and microalgae from the soil and drain water sources are efficient free radical scavengers, containing apoptogens capable of stimulating apoptotic cascades and overcoming chemo-resistance in cancer therapy. Thus, these novel secondary metabolites are an excellent alternative, safe, and low-cost antioxidant and anticancer therapeutic compounds.In this study, two software tools, namely the ERICA Assessment Tool and the RESRAD-BIOTA code, are used for the calculation of the radiological exposure of non-human organisms. For the purposes of the analysis, data retrieved from field studies are used. The site-specific measurements were performed on organisms (mammals-sheep and goats of Bovidae spp.) collected from free-ranged grazing regions in Greece. Plants (grass) of Poaceae spp. and soil samples were also collected from these regions. Natural radionuclides (226Ra, 228Ra, and 228Th) of lithogenic origin and 137Cs, resulted from human activities (Chernobyl and Fukushima nuclear power plant accidents and global fallout), were detected in all samples. The measured activity concentrations were used as input to the two software tools, the ERICA Assessment Tool and the RESRAD-BIOTA code. The results of the simulations provided the external, internal, and total dose rates received by the organisms due to the exposure to the radionuclides. The assessments indicated that out of all detected radionuclides, 228Th is the main contributor to the external dose and 226Ra and 228Ra are the main contributors to the internal dose. The comparative analysis of the two tools revealed significant differences in the calculated doses. In fact, external and internal doses calculated by RESRAD-BIOTA are higher than the values calculated by the ERICA Tool, due to the dose conversion coefficients (DCCs) used for the dose calculation. RESRAD-BIOTA provides more conservative values, but ERICA Tool provides lower uncertainty due to the higher flexibility in the design of the phantom organism. On a risk assessment basis, there is no significant impact, due to organisms’ exposure to radioactivity. However, further consideration of the exposure levels is required due to the potential effects of protracted low-level ionizing radiation on the various levels of life’s organization.The continuous decline in the resource and environment-carrying capacity of cultivated land resources has seriously threatened the sustainable supply of cultivated land resources in China. Using the Hicks-Moorsteen total factor productivity index method, we examine the total factor productivity of cultivated land use (CL-TFP) in China from 2003 to 2017 under environmental constraints. We further use a panel Tobit model to estimate the effect of its influencing factors. The results show that the CL-TFP presents a fluctuating upward trend and reaches data envelopment analysis (DEA) efficiency during the sample period. The regional results reveal a significant spatial difference, especially in the mid-west region, which fails to reach DEA efficiency. China’s main cultivated land did not realize economies of scale. The phenomenon of spatial polarization in what we refer to as very low-value areas and very high-value areas is clear, and the changes are gradual. Regarding the determinative influencing factors, results from the panel Tobit model show that cultivated land usage tax and environmental pollution control investment have no significant effect on CL-TFP, while income level and agricultural intermediate consumption do have a positive effect on CL-TFP. The empirical evidence can help policymakers craft and frame effective policies that improve the utilization efficiency of China’s cultivated land resources.Urban street dust was collected from 22 locations in Riyadh, Saudi Arabia, and nine metals (Pb, Cr, Zn, Co, Cu, Al, Fe, Mn, and Ni) were investigated. The concentrations of these metals were employed in several common contamination evaluation indices to examine the contamination and the health risk caused by metals. Evaluation of these indices showed that they had variable degrees of contamination sensitivity. For individual contaminating elements (Pb, Cr, Zn, Co, Cu, and Ni), the sensitivities of the contamination of contamination factor (CF), the potential ecological risk (Ei), and geo-accumulation index (Igeo) were very similar. Therefore, these indices should yield very similar results. However, enrichment factor (EF) exhibited a different sensitivity pattern for determining the contamination caused by metals compared with the contamination level indicated by the other indices used in this study. Therefore, to avoid potential false indication of contamination, it is not recommended to use EF alone for determining contamination level. As indicated by four contamination evaluation indices (CF, Ei, Igeo, and EF), Riyadh was mainly contaminated by Pb. However, the health risk assessment results revealed that the Pb contamination level did not exceed the significant risk level for non-cancer effects. The cancer risk values indicated a negligible cancer risk to inhabitants of Riyadh exposed to metals associated with street dust. Considering the comprehensive contamination evaluation indices, the ecological risk index (RI) showed that about 77% of the sampling locations featured high ecological risk of which approximately 41% also featured high contamination indicated by pollution load index (PLI).Clear speech refers to intentionally modifying conversational speech to maximise intelligibility. This study aimed to compare the speech behaviour of patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and Parkinson’s disease (PD) under conversational and clear speech conditions to gain greater pathophysiological insight. A total of 68 participants including 17 PD, 17 MSA, 17 PSP and 17 healthy controls (HC) performed two readings of the same standardized passage. During the first reading, participants were instructed to read the text in an ordinary way, while during the second reading to read the text as clearly as possible. Acoustic analyses were based upon measurements of mean loudness, loudness variability, pitch variability, vowel articulation, articulation rate and speech severity. During clear speech production, PD patients were able to achieve improvements mainly in loudness (p  less then  0.05) and pitch variability (p  less then  0.001), leading to a reduction in overall speech severity (p  less then  0.001), whereas PSP and MSA patients were able to modulate only articulation rate (p  less then  0.05). Contrary to HC and PD groups, which slowed or maintained articulation rate, PSP and MSA groups employed a markedly faster articulation rate under the clear speech condition indicating an opposing approach to speech adaptation. Patients with atypical Parkinsonism showed a different strategy to intentionally improve their speech performance following a simple request to produce speech more clearly compared to PD, suggesting important therapeutic implications for speech rehabilitation management.Despite its clinical relevance, cerebral amyloid angiopathy (CAA) is underdiagnosed worldwide. This retrospective study aimed to assess the incidence, etiology, predictors, and outcome of intracerebral hemorrhages (ICHs) in this region, with special focus on possible underlying CAA. Database screening of acute cares with intracranial hemorrhage diagnosis within 01/07/2014-01/07/2018 were conducted analyzing medical records and imaging. Spontaneous ICHs were classified as deep (basal ganglionic/thalamic/brainstem) and lobar/cerebellar (i.e., CAA-compatible) ICHs. Probable/definite CAA was established using the modified Boston criteria in a subgroup with 'complete’ radiological/neuropathological work-up. The ability of several factors to discriminate between deep and lobar/cerebellar ICHs, between probable/definite CAA and non-probable CAA cases, and to predict 1-month case fatality was assessed. Of the 213 ICHs identified, 121 were in deep and 92 in lobar/cerebellar localization. Sub-analysis of 47 lobar/cerebellar ICHs with 'complete’ work-up identified 16 probable/definite CAA patients, yielding an estimated 14.7% prevalence of CAA-related ICHs. Chronic hypertension was the most prevalent risk factor for all types of ICHs (including CAA-related), with hypertensive excess and younger age being independent predictors of deep whereas antiplatelet use of lobar/cerebellar localization. The 1-month case fatality was 33.8%, driven predominantly by age and INR > 1.4. Probable/definite CAA diagnosis was independently predicted by age, prior intracranial hemorrhage, and antiplatelet use. First in this region and among the few in the literature, this study reports a remarkable prevalence of CAA-related ICHs, emphasizing the need for an increased awareness of CAA and its therapeutic implications, especially regarding antiplatelets among the elderly.Vascular cognitive impairment (VCI) is a common feature of vascular brain lesions. The heterogeneity of clinical presentation after a stroke makes it challenging to find. However, the Montreal Cognitive Assessment Scale (MoCA) may be suitable for such purpose. Aim of the present study was to validate the Slovenian version of MoCA for detecting cognitive impairment after ischemic stroke. Seventy patients up to three months after ischemic stroke and 69 age-matched healthy control were included. All performed the MoCA and Hachinski Ischemic Scale (HIS). Cut-off value, sensitivity, specificity and likelihood ratio of MoCA were calculated with the receiver operating characteristic curve. Mean age of healthy controls was 67.1 (SD 9.2) years, mean MoCA was 25.8 (SD 2.6) points, and mean HIS was [1.9 (SD 1.5). There were no age differences between healthy controls and patients [70.4 (SD 10.9) years]. However, patients performed significantly worse on MoCA [mean 18.7 (SD 6.3) points) and had higher HIS score (7.6 (SD 0.3) points]. Optimal cut-off values for MoCA were 24/25 points. The area under the curve was 0.86, sensitivity was 81%, and specificity was 70%. A negative correlation was found between MoCA and education and age. Our results demonstrate that an optimal cut-off for screening for VCI in the Slovenian population is 24/25 points on MoCA, which is similar to other studies performed on patients with different cultural background. The test is easy to perform and could be used in daily clinical practice.Anxiety is common in patients with atrial fibrillation (AF). The mutual causal effect between anxiety and AF is expected with limited evidence. Atrial cardiopathy is a term to describe structural or electrophysiological atrium abnormality that precedes the onset of AF. This study aimed to investigate the association of anxiety with atrial cardiopathy, giving a clue to the causal relationship of this mind-heart link. This cross-sectional study analyzed 532 patients who were free of AF, atrial flutter, stroke, acute coronary syndrome and valvular heart disease. Atrial cardiopathy was defined as P-wave terminal force in lead V1 > 5000 μV·ms on electrocardiogram or severe left atrial enlargement on echocardiogram. Generalized anxiety disorder was ascertained by a score of > 17/56 on Hamilton anxiety rating scale. Multivariable logistic regression was used to explore the association of anxiety with atrial cardiopathy. A total of 65(12.2%) patients had atrial cardiopathy and 53(10.0%) had generalized anxiety disorder, respectively.