07%) (

< 0.05). The total incidence of complications (7.32%) was significantly lower in the observation group than that in the control group (25.58%) (

< 0.05). The overall satisfaction rate was significantly higher in the observation group than the control group (

< 0.05).

The clinical effect of four-step pouch plastic surgery in ocular plastic surgery is significant.

The clinical effect of four-step pouch plastic surgery in ocular plastic surgery is significant.

To explore the impact of humanized nursing care on negative emotions and quality of life (QOL) of patients with mental disorders.

Among the 112 patients with mental disorders treated in our hospital from July, 2017 to November, 2019, 53 who received routine care served as the control group and 59 who received humanized nursing care were in the observation group. Changes in self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores were compared for mental status assessment, and the generic quality of life inventory-74 (GQOL-74) was used to evaluate their QOL. Besides, patient satisfaction, scores of activity of daily living (ADL) scale and mini-mental state examination (MMSE) were compared after intervention.

After intervention, patients in the observation group had higher scores in the self-rating anxiety scale, self-rating depression scale, the generic quality of life inventory-74, and mini-mental state examination, and lower scores in the activities of daily living scale; they also presented a higher overall satisfaction than those in control group.

Humanized nursing care contributes to the relief of negative emotions and the enhancement of quality of life of patients with mental disorders, which is worth popularizing in clinical nursing services.

Humanized nursing care contributes to the relief of negative emotions and the enhancement of quality of life of patients with mental disorders, which is worth popularizing in clinical nursing services.

To investigate the perioperative complications and safety of microwave ablation (MA) therapy for patient’s non-small cell lung cancer (NSCLC) combined with severe chronic obstructive pulmonary disease (COPD).

A total of 28 patients with NSCLC combined with severe COPD in our center were analyzed for complications during MA therapy and post-treatment outcomes.

All patients were successfully ablated by puncture, with a tumor efficiency of 85.7% and no death within 30 days. The tumor tissues showed hypodense changes, cavitation, and decreased CT values when the CT was reexamined 24 hours after surgery. A total of 24 patients showed different surgery-related complications, and were cured after targeted treatments. During the follow-up, the lung tumor disappeared, while the fibrous scars and foci as well as pulmonary cavity still remained. CT imaging examination showed there was no enhancement in the tissue after resection.

In this study, we confirmed that the complications of NSCLC combined with severe COPD after MA were manageable, safe and effective.

In this study, we confirmed that the complications of NSCLC combined with severe COPD after MA were manageable, safe and effective.

To investigate the clinical efficacy and safety of crizotinib and alectinib in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) treatment and the predictive value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 125 (CA125) for treatment efficacy.

A total of 120 patients with ALK-positive NSCLC were enrolled and randomly assigned to receive crizotinib treatment (54 patients, the control group) or alectinib treatment (66 patients, the research group). Treatment efficacy, adverse reactions, survival, and quality of life of patients were compared between the two groups. Enzyme-linked immunosorbent assay was used to determine the serum CEA and CA125 concentrations and these levels were compared between patients with certain treatment responses or no responses. Receiver operating characteristic curve was used to assess the predictive value of CEA and CA125 for treatment efficacy.

The overall disease control rate, overall response rate, and number of 1-year survival patients were substantially higher in the research group compared with the control group. Moreover, the incidence of adverse reactions was significantly lower and progression-free survival and overall survival rates were higher in the research group compared with those in the control group. The area under the curve (AUC) for predicting treatment efficacy was 0.889 for CEA and 0.866 for CA125.

Alectinib was clinically more efficacious and safer than crizotinib for ALK-positive NSCLC treatment. Both CEA and CA125 demonstrated excellent predictive value for treatment efficacy.

Alectinib was clinically more efficacious and safer than crizotinib for ALK-positive NSCLC treatment. Both CEA and CA125 demonstrated excellent predictive value for treatment efficacy.

This study aims to demonstrate the effect of the arthroscopic minimally invasive technique on the clinical symptoms and lower limb functional recovery in knee joint bone trauma patients.

From January 2015 to January 2020, 150 knee joint bone trauma patients were recruited as the study cohort and divided into two groups according to the different intervention method each patient underwent. The patients in the control group (the CG, n=68) were administered routine treatment, and the patients in the research group (the RG, n=82) were treated using the arthroscopic minimally invasive technique. The postoperative clinical operative indexes and the clinical effectiveness, as well as the intraoperative complications were observed in the two groups. The inflammatory factor levels before and after the surgeries were compared. The Visual Analogue Scale (VAS) was employed to evaluate the pain levels before and after the surgeries, the Hospital for Special Surgery Knee Scores (HSS) were used to assess the knee joint y of the knee joint and the lower limbs.

The arthroscopic minimally invasive technique is effective at treating patients with knee joint bone trauma, and it can promote the surgical recovery of patients and facilitate the functional recovery of the knee joint and the lower limbs.

To explore the clinical value of dNLR and TILS in the prognostic diagnosis of breast cancer (BC) and the efficacy evaluation of neo-adjuvant chemotherapy.

From January 2012 to January 2014, 72 patients with BC who received neo-adjuvant chemotherapy in our hospital were selected for this study and analyzed retrospectively. The clinical value of dNLR and TILS in the prognosis of BC was observed, and the clinical data of the patients were collected for Cox regression analysis to observe their independent prognostic indicators. According to the clinical efficacy of neo-adjuvant chemotherapy, patients were divided into effective group (EG) (CR+PR) and invalid group (IG) (SD+PD), and the value of dNLR and TILS in the therapeutic effect of patients was observed.

After therapy, there were 10 cases of CR, 44 cases of PR, 13 cases of SD and 5 cases of PD in 72 patients. With the improvement of curative effect, the expression of dNLR was gradually declined (P < 0.05). The less effective the patients were, the less TILS positive rate was (P < 0.05). However, the expression of dNLR in the EG was obviously lower than that in the IG (P < 0.05). The area under dNLR curve was 0.844, while the area under TILS curve was 0.618. Multivariate Cox regression analysis revealed that TNM staging, dNLR and TILS were independent prognostic factors that affected the patients.

Patients with high expression of dNLR and TILS-negative BC have poor efficacy of neoadjuvant chemotherapy, and dNLR and TILS can be used as prognostic observation indexes for BC.

Patients with high expression of dNLR and TILS-negative BC have poor efficacy of neoadjuvant chemotherapy, and dNLR and TILS can be used as prognostic observation indexes for BC.

This study was designed to determine the effect of high-quality nursing on patients with gestational diabetes mellitus (GDM).

A total of 114 patients diagnosed with GDM in our hospital between December 2016 and December 2018 were enrolled, and assigned to a high-quality group (HQ group; n=64) and a normal group (Nor group; n=50). Patients in the HQ group were nursed under the high-quality nursing mode, while those in the Nor group were nursed under the routine nursing mode. The following items of all patients were determined Blood glucose index, serum lipids index, insulin resistance index, mental health level, treatment compliance, total effective rate of diabetes mellitus treatment, incidence of adverse reactions, and satisfaction.

Compared with the Nor group, the HQ group showed higher levels of fasting blood glucose, 2-hour postprandial blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, and lower levels of high-density lipoprotein-cholesterol, and also showed lower Homa IR and incidence of adverse reactions, with lower Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores, and showed higher treatment compliance, total effective rate of diabetes mellitus treatment, and overall satisfaction.

High-quality nursing can effectively improve the blood glucose level and psychological state of patients with GDM, and contributes to higher treatment compliance.

High-quality nursing can effectively improve the blood glucose level and psychological state of patients with GDM, and contributes to higher treatment compliance.

To evaluate the efficacy of dendritic cell-cytokine-induced killer cell (DC-CIK)-based immunotherapy combined with chemotherapy in the treatment of intermediate to advanced non-small cell lung cancer (NSCLC) and its effect on the levels of serum carbohydrate antigen 199 (CA199), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1).

Sixty patients with intermediate to advanced NSCLC who were treated in the Department of Oncology of Jiangxi Cancer Hospital from January to June 2016 were grouped according to a randomized double-blind method, including the control group (CG, n=30) receiving a routine chemotherapy regimen and the experimental group (EG, n=30) receiving DC-CIK immunotherapy plus a routine chemotherapy regimen. The treatment efficacy, major adverse reactions, immune function, level of cytokines in peripheral blood, serum tumor markers and CA-199, MMP-9, TIMP-1 and vascular endothelial growth factor (VEGF) levels were compared between the two groups.

The overa’ cellular immune function, reducing the inflammatory response, regulating tumor marker levels, and inhibiting tumor invasion and metastasis, without increasing adverse reactions.

To explore the influence of shortening preoperative fasting on the comfort and gastrointestinal function of patients undergoing elective laparoscopic surgery.

a total of 179 patients undergoing elective laparoscopic cholecystectomies (LC) in our hospital from March, 2019 to August, 2020 were recruited as the study cohort and placed into the research group (n=97) or the control group (n=82) according to different fasting periods assigned to each patient. In the control group, the patients were subjected to 12-h fasting and 6-h water deprivation before their surgeries, and the patients in the research group were subjected to 6-h fasting and 2-h water deprivation. The preoperative hunger and thirst, comfort, anxiety, and intraoperative aspiration, as well as the postoperative hospital stay durations, the blood glucose levels, the nausea and vomiting, the pain levels, and the times to the recovery of gastrointestinal function were compared between the two groups.

The research group had shorter hospital stay durations and decreased blood glucose levels.