Finally, the proposed method has been applied to an HIV vaccine trial including 17 HIV-infected patients with 10 repeated measurements of 20,000 gene transcripts and blood concentration of human immunodeficiency virus RNA. The approach selected 21 gene transcripts for which the association with HIV viral load was fully relevant and consistent with results observed during primary infection.Degenerative disease of the lumbar spine is often ignored as a potential cause of testicular pain because the exact link between the two remains uncertain. This article reports the case of a 60-year-old man with a 3-year history of low back pain and unexplained right testicular pain for 2 years. Painful symptoms were negatively affecting his social, physical, and sexual functions. After failure to achieve pain relief through multiple types of therapy, the patient sought chiropractic treatment for his condition. Lumbar spine magnetic resonance imaging (MRI) revealed disc protrusion at the L1/L2, L3/L4, and L4/L5 segments causing thecal sac indentations. Due to the absence of direct testicular causes, the medical impression was chronic testicular pain (CTP) complicating lumbar disc disease. The patient experienced regular improvement in his low back and testicular pain with complete resolution of both after 8 weeks of chiropractic treatment. This article describes an overlook of the etiology of this patient’s testicular pain and a successful option in treating the patient. CTP has multifactorial etiology. An excellent treatment outcome depends heavily on recognizing the origin of the pain.In Korea, suicide by nurses due to workplace verbal violence has become a serious social controversy. This study used a descriptive survey to identify factors influencing nurses’ experiences with being either victims or perpetrators of verbal violence among colleagues. Participants were 205 nurses working at large-scale general hospitals in D city in August 2019. Data were collected through standardized questionnaires on experiences of verbal violence, committing acts of verbal violence, demographic characteristics, and job stress. For experiences of verbal violence, statistically significant differences were observed in age, gender, and nightshift work. Committing acts of verbal violence showed statistically significant differences in age, gender, entire career experience, career experience in one’s present division, and nightshift work. A significant correlation was found between experiences of verbal violence, committing acts of verbal violence, and job stress. Gender and nightshift work influenced experiences of verbal violence in Model 1, while gender, nightshift work, and relationship conflicts were extracted in Model 2. In Model 3, career experience and committing acts of verbal violence were found to be significant. For committing acts of verbal violence, gender, nightshift work, and career experience were extracted in Model 1; gender, nightshift work, and relationship conflict were extracted in Model 2; and nightshift work, career experience, and experiences of verbal violence were significant in Model 3. Regarding verbal violence among nurses, a vicious cycle caused by job stress exists, in which newly hired nurses are often victims of verbal violence; however, as they gain career experience, they become the perpetrators. Therefore, to reduce nurses’ job stress, it is necessary to operate job stress-control programs by career level, promote conversations among nurses to increase understanding of each other, and build a culture of mutual respect.

Endovascular surgery is minimally invasive, but the radiation exposure can be problematic. There is no report assessing whether radiation exposure can be reduced by using a low pulse rate during carotid artery stenting (CAS). The aim of this study was to evaluate whether reducing the pulse rate from 7.5 to 4 frames per second (f/s) can reduce the radiation exposure while maintaining safety during CAS procedure.

We retrospectively reviewed the radiation data and clinical features of all 100 patients who underwent CAS between 2014 and 2019. We changed the pulse rate from 7.5 to 4 f/s in 2017. The fluoroscopic time (FT), dose area product (DAP), and total air kerma (AK) were collected. Statistical analyses were performed between the pulse rate and clinical outcomes, including radiation exposure.

We retrospectively reviewed the radiation data and clinical features of all 100 patients who underwent CAS between 2014 and 2019. We changed the pulse rate from 7.5 to 4 f/s in 2017. The fluoroscopic time (FT), dose area product (DAP), and total air kerma (AK) were collected. Statistical analyses were performed between the pulse rate and clinical outcomes, including radiation exposure.

Hyperperfusion syndrome (HPS) following carotid artery stenting (CAS) is a rare but life-threatening complication. Staged angioplasty (SAP) is an alternative method that prevents HPS by preventing a sudden increase in cerebral blood flow. In this study, we investigated the safety and efficacy of SAP.

A total of 114 patients with carotid stenosis underwent CAS treatment in our hospital between September 2014 and September 2019. Patients with severe stenosis and poor collateral circulation shown on digital subtraction angiography (DSA) and hypoperfusion of the ipsilateral diseased blood vessel shown on computed tomography perfusion (CTP) imaging were subjected to SAP treatment (the SAP group), and other patients received regular CAS treatment (the RS group).

Twenty-two patients (19.3%) with a high risk of HPS underwent SAP treatment, 1 of whom had carotid dissection after stage I balloon angioplasty and underwent regular CAS. This patient had HPS after surgery. None of the other patients in either group had HPS. One patient in the SAP group (4.5%) had hyperperfusion phenomenon (HPP) after stage II stenting, and 2 patients in the RS group (2.2%) had HPP. One patient in the SAP group (4.5%) and 4 patients in the RS group (4.3%) had symptomatic ischemic complications postoperatively. None of the differences between the 2 groups were statistically significant. Three patients had reduced modified Rankin Scale (mRS) scores at 90 days after discharge.

This research suggests that SAP appears to be an effective method to prevent HPS for patients with a high risk of HPS.

This research suggests that SAP appears to be an effective method to prevent HPS for patients with a high risk of HPS.

Cannabis use for medical condition has significantly increased over the past 20 years with 33 states and the District of Columbia passing laws legalizing medical cannabis. Five qualifying psychiatric disorders have been identified. The objective of this review article is to present a brief history of medical cannabis, the evidence for the qualifying psychiatric conditions, and to discuss the implications for psychiatric nurses.

A review of the literature on the five qualifying psychiatric disorders was conducted. Databases searched included CINAHL, PubMed, Cochrane Library, MedLine Plus, and EMBASE. Keywords were cannabis, medical cannabis, delta-9-tetrahydrocannabinaol, cannabidiol, and psychiatric disorders.

The evidence that medical cannabis or cannabinoids is an effective treatment for the qualifying psychiatric disorders (e.g., posttraumatic stress disorder, agitation in Alzheimer’s disease and other dementias, Tourette’s syndrome, anxiety, and obsessive-compulsive disorder) is too weak and of low s opportunities for psychiatric nurses to make an impact both clinically and be conducting research in this emerging field. We need to educate ourselves and our patients about the benefits and risks of medical cannabis and to help patients make informed decisions about their health care.Objectives This study examined the associations between parent-child relationships and sleep difficulty among older parents in the context of Chinese multiple-children and one-child families. Methods Using the 2014 China Longitudinal Aging Social Survey, this study analyzed older parents’ (N = 8,450) reports of sleep quality and relationships with each of children. Results Results from multivariate logistic regression models showed that living alone, greater variations in children’s financial transfers and emotional closeness, and more instrumental support from children were associated with higher risks of sleep difficulty for Chinese older parents with multiple children. The maximum levels of financial transfers and emotional closeness from all children were related to lower risks of sleep difficulty for parents from multiple-children families, while greater instrumental support from children was associated with higher risks of sleep difficulty for parents from one-child families. Discussion Findings have implications for support programs for Chinese aging population with sleep problems.This study explored the relationship between the opioid epidemic and elder abuse. Twenty professionals from four states with working knowledge of elder abuse cases participated in focus groups. Thematic analysis revealed four themes characterizing the relationship between opioid misuse and elder abuse (a) Opioid-Related Elder Abuse is an Escalating Problem; (b) Vulnerable Older Adults are Prisoners in Their Own Home; (c) Health Care Professionals Perpetrate Opioid-Related Elder Abuse; and (d) Older Adults Abuse and Deal Opiates. In addition, all participants noted the lack of reliable, retrievable data to address cases of elder abuse when opioids are involved. Findings lay the groundwork for further research to understand the breadth and depth of the opioid-elder abuse relationship that can ultimately be used to develop prevention and intervention strategies and policies to address this hidden but widespread concern.

The aim of this study was to devise a novel test for assessing the cervico-ocular reflex (COR) system

head vibration (termed h-COR) or neck vibration (termed n-COR) method.

Thirteen patients with complete loss of bilateral vestibulo-ocular reflex (VOR) showing oscillopsia were assigned to Group A, while 13 patients with bilateral VOR loss but no oscillopsia were Group B. Another 13 healthy elderly served as a control. The COR test was performed

modifying the ocular vestibular-evoked myogenic potential (oVEMP) test by tapping at the forehead with head rotation (h-COR) or at mid-dorsal neck with head straight (n-COR).

Both h-COR and n-COR tests displayed similar cI-cII waveforms. None of the Group A or healthy elderly showed present h-COR, while 8% of Group A and 31% of the healthy elderly revealed present n-COR. In contrast, present h-COR and n-COR were elicited in 85 and 77% of Group B, respectively. Restated, significantly higher response rate of COR in Group B (without oscillopsia) than Group A (with oscillopsia) indicates that present COR is related to the alleviation of oscillopsia.

Head vibration method (h-COR test) is superior to neck vibration method (n-COR test) for assessing the COR system.

Head vibration method (h-COR test) is superior to neck vibration method (n-COR test) for assessing the COR system.Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the CNS which is distinct from multiple sclerosis and typically presents with a relapsing course of optic neuritis, myelitis and midline brain inflammatory lesions. In at least two-thirds of cases, antibodies against the water channel AQP4 can be found, which lead to an antibody-mediated activation of the complement system with consecutive damage to neuronal structures. Eculizumab, a humanized monoclonal antibody against the terminal complement component 5, was shown to significantly reduce the risk of NMOSD relapse in a Phase III placebo-controlled trial. Based on this, eculizumab (Soliris®) was the first drug to be formally approved for the treatment of anti-AQP4-antibody positive NMOSD in 2019.