The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.

Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.

To study the primary diagnosis of schizophrenia spectrum disorders within the framework of an inpatient forensic psychiatric examination.

A retrospective analysis of 52 accused, who underwent inpatient forensic psychiatric examination at Alexeev Mental Clinic No. 1 in the period 2018-2020, was carried out. Patients were divided into two groups. Group 1 included 39 patients newly diagnosed with paranoid schizophrenia and group 2 consisted of 13patients diagnosed with schizotypal disorder. Diagnosis was based on the ICD-10 criteria (F20 and F21). Clinical and psychopathological method was used as the main research tool.

The study group is represented mainly by young people (88.4%,

=46) with secondary (78.8%,

=41), less often higher (21.25,

=11) education, with a decrease in social adaptation and signs of «social drift» (90.3%,

=47). Difficulties in diagnosis at the initial stages of an endogenous disease are due to the presence of neurotic disorders that do not affect the nature of social functioning. In group 2, there was a slow increase in personality changes. The commission of unlawful actions by productive-psychopathological mechanisms was observed in 73% of cases (

=38).

The primary diagnosis of endogenous mental disorders in a forensic situation, carried out during an inpatient forensic psychiatric examination, determines the correctness of the assessment of the level of danger and the choice of compulsory medical measures.

The primary diagnosis of endogenous mental disorders in a forensic situation, carried out during an inpatient forensic psychiatric examination, determines the correctness of the assessment of the level of danger and the choice of compulsory medical measures.Currently there is a new concept of «molecular neuropsychiatry» which aim is identification of biomarkers and biological substrates for mental disorders. Autoimmune encephalitis can start with psychiatric symptoms in 60% of cases. In this article we described a clinical case of a patient, 31 years old, with GABAb-associated AE started with acute polymorphic psychosis. AE was diagnosed and treated in time with a good clinical effect. According to the frequency of psychiatric symptoms in AE patients it should be reasonable to include antineuronal test in CSF and serum in patients with first acute psychosis if «red flags» or atypical course of the disease.The goal of the up-to-date treatment of patients with schizophrenia spectrum disorders is recovery, including personal recovery. This goal is a part of the patient-centered approach. This review examines factors that may influence recovery achievement. Compliance plays a key role in relapse prevention. Its formation, in turn, depends on patients’ participation in the treatment process, level of insight and patients’ ability and willingness to play an active role in the treatment and apply self-management. All of the mentioned above should be taken into account while implementing patient-centered approach. This dictates the need to develop clear evaluation criteria of recovery factors in medical care of patients with schizophrenia spectrum disorders.

To study the medical and social characteristics of patients with the first episode of endogenous mental disorders and to compare them with the level of social functioning in the two-year follow-up.

The study included 512 case histories of patients with ICD-10 diagnoses F20, F21, F23, F25, F31, F32. Patients were admitted to a 24-hour hospital in the period from 2018 to 2019. Clinical and psychometric methods were used. The level of social functioning was measured with the Personal and Social Performance Scale (PSP).

At baseline, 23.8% (

167) of patients met the criteria of the code F23 and 6.8% (

=35) of the code F25. Two years later the diagnoses were distributed as follows F25 – 39.96% (

=205) and F21 – 17.4% (

=180). Affective disorders predominated in female patients (women – 23.6%;

=72; men – 18.7%,

=39), schizophrenia spectrum disorders were more frequent in men (81.3%;

=167) compared with women (75.5%,

=156). At the time of admission to the hospital, the number of non-working and non-student patients prevailed (52.4%,

=268). Most of them were female patients (31.5%,

=161). According to PSP, the majority of patients had moderate impairment of social functioning (82.0%) at the start of the study. After 2 years of follow-up, the majority of patients showed mild impairment of social functioning (92.0%).

The results obtained indicate a rather favorable variant of the course of endogenous mental disorders over the period studied, which may be due to the volume of complex specialized care provided.

The results obtained indicate a rather favorable variant of the course of endogenous mental disorders over the period studied, which may be due to the volume of complex specialized care provided.This review aims at studying the development and application of the provisions of the International Classification of Functioning, Disability and Health in the practice of domestic psychiatry. Publications on the quality of life and satisfaction with medical care for disabled people with schizophrenia spectrum disorders are reviewed. The review shows that with a decrease in the number of patients with mental disorders in the Russian Federation, the number of people with disabilities due schizophrenia spectrum disorders is growing. The study of the aspect of the quality of life of patients with schizophrenia spectrum disorders reveals a slow development of this scientific area, especially due to the lack of standardized and validated methods. The aspect of satisfaction with medical care for people with schizophrenia spectrum disorders is also insufficiently studied, and, being directly related to the quality of life of patients, similarly lacks specialized assessment methods. It is also necessary to assess the influence of these factors on the formation of medical and social significance of the problem of disability of the population.Genotype – phenotype relationships are considered in view of recent advances in our understanding of genome structure. Different DNA elements can contribute to phenotype formation. Genotype – phenotype relationships are mediated by epigenetic effects that can have various origins – from the most studied to date methylation of certain sites in the genome to only developing ideas about the role of remote regulatory genomic elements in the development of schizophrenia. The transition to a more in-depth study of genotype – phenotype relationships is relevant for the current period of molecular-genetic studies of schizophrenia. Obviously, the concept of phenotype as applied to schizophrenia is not limited to a causal reflection of changes in the structure of a particular gene, but is the product of the combined effect of environmental factors and epigenetic changes that affect gene expression, taking into account tissue specificity and the degree of cell stimulation.

To analyze clinical and therapeutic features of the transfer of patients with schizophrenia spectrum disorders from paliperidone palmitate of one-month action (PP-1M) to paliperidone of three-month action (PP-3M).

Data on the psychopharmacological therapy regimens of 677 patients with verified diagnoses of schizophrenia spectrum disorders (F20, F21, F25) treated with PP-3M drugs after PP-1M therapy were studied.

The study showed the high efficacy of ultra-long-acting paliperidone therapy in 82.2% of patients with schizophrenia spectrum disorders. The unfavorable dynamics of the mental state in patients when transferring from the drug PP-1M to PP-3M was 14.0%, the return to therapy with PP-1M or tablet forms was 3.8%. Successful management of patients on PP-3M was not associated with sex and age, but was correlated with some clinical and therapeutic indicators. The most successful therapy with PP-3M was noted with the earlier appointment of PP-3M mainly as monotherapy, provided the previous stable condit-19 pandemic.

To study the spectrum of inflammatory markers and their association with the psychopathological symptoms in patients with youth schizophrenia in the long-term follow-up study.

Thirty-four male patients with schizophrenia (ICD-10 F20) first manifested at the age of 16-25 years were followed-up for 20-25 years (mean duration 22±2.9 years). The mean age of patients at the time of follow-up examination was 46.7±3.2 years. PANSS and PSP scales were used to quantify the severity of psychopathological symptoms. The control group consisted of 20 mentally and somatically healthy people matched for age with the patient group. The immunological parameters (the activity of the neutrophil protease of leukocyte elastase (LE) and its endogenous inhibitor α1-PI, as well as the level of antibodies to S100B and basic myelin protein) included in the medical technology «Neuroimmunotest» were determined in blood plasma.

Three types of follow-up outcomes of youth schizophrenia were found the first type – with a predominance ith damped inflammation or depletion of the inflammatory potential).

Residual psychopathological symptoms observed in the late stages of schizophrenia can be determined by both low/moderate inflammation and genetic mechanisms (in patients with damped inflammation or depletion of the inflammatory potential).

Stem cells have been identified from various adult sources, including bone marrow, adipose tissue, and placenta, to name a few. Recently, the fallopian tube has also been identified as a novel source of therapeutics. However, the ability of stem cells from the fallopian tube mucosa to retain prolonged efficacy of proliferation and differentiation is yet to be explored. This forms the basis of the present study.

Stem cells isolated from the fallopian tube mucosa were tested for their marker characterization (markers of mesenchymal, pericyte, epithelial, and cell adhesion molecules) at various passages (P1, P3, P5, P10, P15). Proliferation, differentiation (osteoblast and adipocytes), and karyotyping were also carried out at both early (P3) and late (P15) passages.

Fallopian tube mucosa possesses mesenchymal stem cells, but they do not retain the ability to proliferate and differentiate beyond P15.

Although fallopian tube mucosal MSCs (FT-MMSCs) possess stem cell attributes, they cannot outweigh or be used in parallel to existing stem cell sources due to their inability to retain stemness characteristics beyond P15. Since FT-MMSC studies are in their infancy, further in-depth research is warranted to test whether FT-MMSCs have a use in bench to bedside applications. FT-MMSCs might be linked to tubal inflammation and fallopian tube hyperplasia, which contributes to a possible role in diagnostics and in providing insights for the betterment of womankind.

Although fallopian tube mucosal MSCs (FT-MMSCs) possess stem cell attributes, they cannot outweigh or be used in parallel to existing stem cell sources due to their inability to retain stemness characteristics beyond P15. Since FT-MMSC studies are in their infancy, further in-depth research is warranted to test whether FT-MMSCs have a use in bench to bedside applications. FT-MMSCs might be linked to tubal inflammation and fallopian tube hyperplasia, which contributes to a possible role in diagnostics and in providing insights for the betterment of womankind.