Posttranslational S-fatty acylation (or S-palmitoylation) modulates protein localization and functions, and has been implicated in neurological, metabolic, and infectious diseases, and cancers. Auto-S-fatty acylation involves reactive cysteine residues in the proteins which directly react with fatty acyl-CoA through thioester transfer reactions, and is the first step in some palmitoyl acyltransferase (PAT)-mediated catalysis reactions. In addition, many structural proteins, transcription factors and adaptor proteins might possess such „enzyme-like” activities and undergo auto-S-fatty acylation upon fatty acyl-CoA binding. Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine residues, providing potential binding sites for covalent and non-covalent modulators. Therefore, targeting auto-S-fatty acylation could be a promising avenue to pharmacologically intervene in important cellular signaling pathways. Here, we summarize the recent progress in understanding the regulation and functions of auto-S-fatty acylation in cell signaling and diseases. We highlight the druggability of auto-S-fatty acylated proteins, including PATs and other proteins, with potential in silico and rationalized drug design approaches. We also highlight structural analysis and examples of currently known small molecules targeting auto-S-fatty acylation, to gain insights into targeting this class of proteins, and to expand the „druggable” proteome.Purpose This study aimed to compare the oxygen consumption, lactate concentrations, and energy expenditure using three different intensities during the resistance training sessions. Methods A total of 15 men (22.9 ± 2.61 years) experienced in resistance training underwent 3 sessions composed of 8 exercises (chest press, pec deck, squat, lat pull-down, biceps curl, triceps extension, hamstring curl, and crunch machine), which were applied in the same order. The weight lifted differed among the sessions [high session 6 sets of 5 repetitions at 90% of 1-repetition maximum (1-RM); intermediary session 3 sets of 10 repetitions at 75% of 1-RM; and low session 2 sets of 15 repetitions at 60% of 1-RM]. The oxygen consumption (VO2)-during and after (excess post-exercise oxygen consumption (EPOC)) the session, blood lactate concentration, and energy expenditure (i.e., the sum of aerobic and anaerobic contributions, respectively) were assessed. Results The VO2 significantly decreased in the function of the weight lifting (F (2.28) = 17.02; p 0.05; η G 2 less then 0.01). Thus, the total energy expenditure during the session (kcal) significantly increased in the function of the weight lifting (F (2.28) = 86.68; p less then 0.01; η G 2 = 0.75). The energy expenditure expressed in time unit (kcal·min-1) was higher in low session than in high session (F (2.28) = 6.20; p less then 0.01; η G 2 = 0.15). Conclusion The weight lifted during resistance training-induced different physiological responses, which induced higher energy expenditure per unit of time during the low session.Sport participation is considered a positive pastime endower that can offer a range of positive outcomes for children and youths. It has also increasingly been recognized as a potentially important context for fostering social inclusion for minority youths. Yet across Europe, minority girls are participating in sport to a lesser degree than their majority counterparts. Using self-determination theory (SDT) and the social ecological model as the framework, this study explored the reasons why a particular project aimed at recruiting minority girls to organized team sport succeeded in doing just that. A case study design was adopted to provide an in-depth analysis of how this project satisfied the basic psychological needs of minority girls. Nine girls, four parents, two coaches, and two project team members were interviewed about the project and sport participation in general. Data were analyzed using thematic analysis. Two main themes were identified, a sense of being facilitated and inclusion in the sport environment. The former emphasized the importance of aligning the participation with the girls’ cultural norms and values, particularly in the beginning. It also included practical issues such as finances, reminding us that participation in sport is not just a motivational issue. The latter focused on the importance of including the girls in the general sports program, regardless of their athletic abilities at the onset of their participation and creating a mastery environment. Moreover, by removing remediable differences between the minority and majority girls, such as having the right equipment, seemed important to fostering a sense of belonging in the sports club. Additionally, establishing meaningful relationships with coaches and majority counterparts seemed to be a major motivating factor.Canoe polo is an increasingly popular discipline requiring both kayaking and ball-handling skills. While the kinematics of the upper body during throw has been investigated for several overhead sports, the canoe polo throw has still to be studied. Therefore, the aim of this study is to analyze the canoe polo throw kinematics in terms of angles and inter-articular sequencing to understand its specificity. A secondary aim was to investigate whether adding pelvis mobility has an impact. Nineteen male players of canoe polo were equipped with reflective body markers for the throw analysis. They performed 5 throws with the pelvis fixed and 5 throws with additional pelvic mobility in rotation around a vertical axis. Inverse kinematics was performed with OpenSim providing pelvis, trunk, and glenohumeral rotations. Angular velocities were calculated to build the inter-articular sequences relative to these throws. Statistical parametric mapping was used to assess the effect of pelvis mobility on the throwing kinematics. Similar kinematics patterns as in other overhead sports were observed, however, a different inter-articular sequence was found for the canoe polo throw with a maximal angular velocity occurring sooner for the thorax in axial rotation than for the pelvis in rotation. While the limitation of rotation of the pelvis around a vertical axis has an influence on the pelvis and trunk kinematics, it did not modify the kinematic sequence.In regular times, implementing exercise-based injury prevention programs into the training routine of high-level and professional athletes represents a key and challenging aspect to decrease injury risk. Barriers to implementing such prevention programs have previously been identified such as lack of resources, logistic issues or motivation. The COVID-19 pandemic associated with restrictions on daily life dramatically impacted sports participation from training to competition. It is therefore reasonable to assume that such lockdown-like context has exacerbated the challenge to implement exercise-based injury prevention programs, potentially leading to a greater musculoskeletal injury risk. In this narrative review, recommendations are proposed for building an expertise- and evidence-based Standard Operating Procedure for injury prevention in lockdown-like contexts for high-level and professional athletes. The following recommendations can be provided (1) assess the global and sport-specific risks in the light of the ongoing cause of isolation; (2) adapt remote training materials and programs; (3) ensure regular quality communication within the staff, between athletes and the staff as well as between athletes; (4) follow the athlete’s mental well-being; and (5) plan for a safe return-to-sports as well as for an ongoing monitoring of the load-recovery balance. These key domains should further be addressed to comply with local policies, which are subject to change over time in each individual country. The use of these recommendations may improve the readiness of athletes, coaches, physicians and all sports stakeholders for future lockdown-like contexts.Youth is characterized by testing and crossing natural boundaries, sometimes with the help of performance-enhancing substances. In this context, doping prevention measures play a crucial role to protect individuals both within and outside the context of elite sport. Based on the PRISMA guidelines, a systematic literature search was conducted in the databases ProQuest (ERIC), Scopus, PSYNDEX/PsychInfo, PubMed, and Web of Science Core Collection to provide an overview of the impact of doping prevention measures, with particular attention to the underlying understanding of learning. As a result of the screening process, 30 of the initial 5,591 articles met the previously defined and recorded eligibility criteria. The analysis led to heterogeneous results regarding content, implementation, target group, or outcome variables considered relevant. Two-thirds of the studies related to the competitive sports context. Nevertheless, there has been a growing interest in studying doping prevention and its effects on non-ed changes, a further modification in doping prevention seems necessary. The review results support the value of primary prevention. Doping prevention measures should enable tailored learning and development options in the sense of more meaningful differentiation to individual needs. The implementation in a school context or an online setting is promising and sees doping as a problem for society. The review highlights the importance of accompanying evaluation measures to identify efficient prevention components that promote health and protect young people.Basketball games and training sessions are characterized by quick actions and many scoring attempts, which pose biomechanical loads on the bodies of the players. Inertial Measurement Units (IMUs) capture these biomechanical loads as PlayerLoad and Inertial Movement Analysis (IMA) and teams collect those data to monitor adaptations to training schedules. However, the association of biomechanical loads with game performance is a relatively unexplored area. The aims of the current study were to determine the statistical relations between biomechanical loads in games and training with game performance. Biomechanical training and game load measures and player-level and team-level game stats from one college basketball team of two seasons were included in the dataset. The training loads were obtained on the days before gameday. A three-step analysis pipeline modeled (i) relations between team-level game stats and the win/loss probabilities of the team, (ii) associations between the player-level training and game loenabled modeling the expected game performance for each individual. Coaches, trainers, and sports scientists can use these findings to further optimize training plans and possibly make in-game decisions for individual player performance.As demands for more sustainable ways of living increase, organisers of sport events have come under increasing pressure to adapt. At the same time, more and more national and local event policies increase the demand for events. These two trends raise the question of how policy makers can combine the demand for events with a sustainable way of living; a question that so far has been subject to little research. The present paper analyses the conceptualisation of sustainability in all local policies relating to events in Norwegian municipalities. The paper is based on the analysis of policies covering 22 municipalities and includes both general development plans and more specific policies on events in its analysis. The analysis shows that all the municipalities have adopted a „broad” conceptualisation of sustainability, i.e., pursued a development, which should not limit the possibilities of future generations, in their general development plans. Although the general development plans serve as a basis for every other policy, the paper also shows that the municipalities in the specific policies for events often had „narrow” conceptualisation of sustainability, i.