To evaluate the effect of hypernatremia on the organization of blood plasma high density lipoproteins (HDL) in goldfish; to compare the state of hypernatremia in fish and humans; to assess the possible risks and consequences of the effect of hypernatremia on human plasma lipoproteins.

The fish were acclimated for 20 days at a critical salinity of 11.5 g/L; after that the salt water was gradually „desalinated”. The concentration of Na+ and the content of total water were determined in tissues, cells, and body fluids. The HDL organization was assessed by the number of apolipoprotein molecules per particle. The methods of flame spectrophotometry, electrophoresis and MALDI were used.

In fresh water, the state of normonatremia was maintained in the fish body; at critical water salinity, the state of hypernatremia. Against the background of hypernatremia, the initial signs of muscle and erythrocyte dehydration appeared in fish, the total water content in the plasma did not change, and HDL disintegrated into sown of HDL prevents the loss of water from the fish organism and reduces the threat of their dehydration. Human hypernatremia is characterized by plasma sodium levels comparable to that in goldfish, however accompanied by life-threatening metabolic changes. The results of this study may be useful for assessing the risks of HDL breakdown at hypernatremia and for the development of protocols for the treatment of pathological conditions in humans (Fig. 4, Ref. 45).

To analyse the main features of the top 100 (T100) most cited articles in academia and 100 most discussed articles on social media about vitamin D from 1975 to 2021 and compare bibliometric and altmetric analysis.

'Vitamin D’ was searched from the Web of Science database and Altmetric.com website, and T100 citation and altmetric lists were created, respectively. Articles in both lists were analysed in terms of study type, topic, first author, publication year, citation number and altmetric attention score (AAS). Impact factor (IF) and quartile of journal, in which the articles were published was also examined.

The article „Vitamin D Deficiency” by Holick MF, published in the New England Journal of Medicine was the most cited article (n=8492), original scientific paper was the most frequent study type in both lists. No correlation was found between AAS and citation number in both lists (r=0.176, p=0.081; r=0.157, p=0.119, respectively). The journals on the T100 citation list had a statistically significantly higher IF than the journals in the T100 altmetric list (p<0.001).

Altmetric analysis of vitamin D is currently insufficient to replace traditional bibliometric analysis but can provide valuable information about the society’s interest. As social media gains more importance every day in our lives, high altmetric score could affect future interests and direct studies (Tab. 6, Fig. 3, Ref. 21).

Altmetric analysis of vitamin D is currently insufficient to replace traditional bibliometric analysis but can provide valuable information about the society’s interest. As social media gains more importance every day in our lives, high altmetric score could affect future interests and direct studies (Tab. 6, Fig. 3, Ref. 21).

The aim of this study was to establish a set of hospitalised patients with persistent pulmonary hypertension of the newborn (PPHN) by using retrospective analysis according to gestational age, position during childbirth, type of childbirth, dosage and length of the treatment by inhaled nitric oxide (NO) and application of inotropic agents as well as interindividual specifics and the background of PPHN.

Our cohort consisted of 11 newborns who were hospitalised in Neonatal Department of Intensive Medicine between 1st January 2017 and 31st December 2019. Four of these patients were born prematurely. Only two out of eleven patients were born vaginally. Nine of the newborns were diagnosed with secondary PPHN, in three of these cases it was caused by infection. The highest dose of inhaled nitric oxide used was 40 ppm.

The focus of this paper was the therapeutic use of nitric oxide, its various applications and the effect of it on pulmonary circulation of the newborn. Inhaled NO is a selective pulmonary vasodilator used as a therapeutic agent for PPHN of the newborn. The conclusions of this paper can be beneficial in the development of better therapeutic strategies for patients with PPHN in the future (Tab. 3, Fig. 1, Ref. 40).

The focus of this paper was the therapeutic use of nitric oxide, its various applications and the effect of it on pulmonary circulation of the newborn. Inhaled NO is a selective pulmonary vasodilator used as a therapeutic agent for PPHN of the newborn. The conclusions of this paper can be beneficial in the development of better therapeutic strategies for patients with PPHN in the future (Tab. 3, Fig. 1, Ref. 40).

Evaluation of selected inflammatory parameters and serum malondialdehyde (MDA) significance in the post-inflammatory period in adult patients with cystic fibrosis.

Laboratory biomarkers can be integrated into clinical practice as part of monitoring the effectiveness of treatment.

After recovery from an acute exacerbation of lung infection, selected inflammatory parameters (fibrinogen, IL-1, IL-6, SAA, hs-CRP) and serum MDA were examined in 30 adult patients with cystic fibrosis. Their correlation with FEV1, frequency and duration of subsequent hospitalizations and 6-year prognosis in terms of mortality or need for lung transplantation was evaluated.

FEV1 negatively correlated with fibrinogen, but positively with MDA. No significant correlation with hs-CRP, IL-1, IL-6 and SAA was recorded. Plasma fibrinogen predicted the frequency and duration of subsequent hospitalizations. The 6-year prognosis was negatively associated with plasma fibrinogen whereas its association with MDA was positive. However, the prognosis of patients in the multivariate analysis was significantly associated only with FEV1.

Plasma fibrinogen examined in the post-inflammatory period is a marker of lung damage in patients with cystic fibrosis and can be used to predict the prognosis. The positive correlation of serum MDA with FEV1 in the post-inflammatory period may be important to the interpretation of treatment interventions (Tab. 3, Fig. 2, Ref. 17).

Plasma fibrinogen examined in the post-inflammatory period is a marker of lung damage in patients with cystic fibrosis and can be used to predict the prognosis. The positive correlation of serum MDA with FEV1 in the post-inflammatory period may be important to the interpretation of treatment interventions (Tab. 3, Fig. 2, Ref. 17).Research has established that certain forms of underemployment relate to poorer mental health, but no studies have examined which components of underemployment are uniquely related to mental health over time. To address this gap in the literature, we longitudinally examined how multiple subjective underemployment constructs (i.e., underpayment, status, involuntary temporary work, field, poverty-wage employment, involuntary part-time work, and overqualification) predicted symptoms of distress in a large sample of working adults in four waves over 9 months. We also identified group differences in underemployment. Results revealed that involuntary part-time work, involuntary temporary work, and poverty-wage employment fluctuated with distress over the course of the study, but only involuntary temporary work predicted greater symptoms of distress over time. Group differences also revealed that gender, age, level of education, and subjective social class predicted various forms of subjective underemployment. Findings encourage researchers, practitioners, and policymakers to consider involuntary temporary work as potentially harmful to mental health and inform the future examination of mental health inequities for marginalized groups. (PsycInfo Database Record (c) 2022 APA, all rights reserved).In the United States, children often generalize the meaning of new words by assuming that objects with the same shape have the same name. We propose that this shape bias is influenced by children’s exposure to objects of different categories (artifacts and natural kinds) and language to talk about them. We present a cross-cultural study between English speakers in the United States and Tsimane’ speakers in the Bolivian Amazon. We found that U.S. children and adults were more likely to generalize novel labels by shape rather than by material or color, relative to Tsimane’ participants. Critically, Tsimane’ children and adults systematically avoided generalizing labels to objects that shared no common features with the novel referent. Our results provide initial evidence that the relative exposure to objects of different kinds and language to talk about them can lead to cross-cultural differences on object name learning. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Stigma is described as highly relevant to the treatment context for opioid use disorder (OUD) partly because it is known to influence providers’ treatment decisions and care provision. However, further study is needed to directly test the salience of stigmatizing views for healthcare decision-making among providers, and particularly those including medication for opioid use disorder (MOUD). This study assessed whether stigma toward illicit opioid use was associated with a willingness to provide or refer patients for MOUD treatment among a sample of healthcare providers. It also evaluated variation in stigmatizing views as a function of familiarity with OUD and MOUD and provider type.

Structural equation modeling was utilized to evaluate the antecedents and healthcare decision-making consequences associated with stigma based on survey data from a sample of 144 clinicians participating in a buprenorphine waiver training program (30% female).

Providers who have less familiarity with OUD and MOUD and those who are medical students or residents are significantly more likely to endorse stigmatizing views of illicit opioid use. In turn, greater stigma is significantly associated with a lesser willingness to provide treatment or refer patients to MOUD treatment.

Further consideration of stigma is recommended in future research to improve clinical practice and increase the implementation of MOUD treatment. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Further consideration of stigma is recommended in future research to improve clinical practice and increase the implementation of MOUD treatment. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Individual placement and support (IPS) is the evidence-based supported employment approach for people with serious mental illness. Because funding is the major barrier for states to implement IPS and increase access, the IPS Learning Community collected information about sources of IPS funding from 24 member states.

In early 2020, IPS employment leaders from the public mental health authority and the state vocational rehabilitation (VR) authority completed a questionnaire identifying sources of funding for IPS in their states.

The main sources of funding were Medicaid, Substance Abuse and Mental Health Services Administration (SAMHSA) block grants, state and county government, the Ticket to Work program, and the federal-state VR programs.

Funding IPS services requires braided funding from multiple sources. This complicated method limits scaling up services statewide. Solving this funding problem would require coordinated action from federal and state agencies. (PsycInfo Database Record (c) 2022 APA, all rights reserved).