The Coronavirus Disease 2019 (COVID-19) pandemic has had far-reaching effects on orthodontic care delivery worldwide. This study aimed to assess the impacts of the pandemic on orthodontists and orthodontic residents in Nigeria.

This cross-sectional study was conducted among consenting orthodontists and orthodontic residents. The respondents were contacted through the WhatsApp group of the Nigerian Association of Orthodontists to fill the self-administered online questionnaires (Google forms). The questionnaire had two sections A, Sociodemographics; B, Perceived impact of the COVID-19 pandemic. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Descriptive statistics were used to compute mean and standard deviation and chi-square for association. Level of significance was set at P < 0.05.

This study population comprised 98 people; however, only 73 participants responded, which represented a response rate of 74.5%. Approximately 60% (44) of the respondents thought that the COVID-19 pandemic would lead to a reduction in the number of orthodontic patients in the future, whereas almost all the respondents reported that it would affect their future practice of orthodontics. Most of the respondents (63.0%) reported that the pandemic had recorded a moderate to severe negative economic impact on them. Significant gender differences were recorded, in the social life of respondents, in addition to economic and psychosocial effects.

Almost all respondents reported that they would change their future practice of orthodontics, particularly with respect to placing a greater emphasis on infection control. Most of the respondents reported perceived economic, psychosocial, and social impacts due to the pandemic.

Almost all respondents reported that they would change their future practice of orthodontics, particularly with respect to placing a greater emphasis on infection control. Most of the respondents reported perceived economic, psychosocial, and social impacts due to the pandemic.

To explore patients’ perspectives and experiences living with moderate to severe glaucoma through qualitative, semistructured interviews and to identify important benefits and risks that patients consider when choosing glaucoma treatments.

Semistructured, in-person qualitative interviews with a convenience sample of patients seen at the Johns Hopkins Wilmer Eye Institute.

Surgery-naive patients 21 years of age or older with moderate to severe open-angle glaucoma seeking treatment at the Wilmer Eye Institute’s Glaucoma Center of Excellence between August and December2018.

We conducted semistructured interviews with patients diagnosed with moderate to severe open-angle glaucoma, focusing on outcomes they prioritize when considering various treatment options. We used Atlas.ti software version 7.5.12 (Scientific Software Development GmbH, Berlin, Germany) to process interview transcripts and the framework approach to analyze the qualitative data.

Patients’ descriptions of outcomes important to them in msymptoms, and disease progression via maintenance of IOP control. We also observed that these patients have varied and nuanced perspectives on surgical management and its outcomes. It behooves providers and trial designers to consider these in future evaluations of new treatments for moderate to severe glaucoma.

We identified outcomes that matter to patients who are undergoing treatment for moderate to severe glaucoma, many of which may serve as end points in clinical trials, such as functional independence in vision-dependent activities of daily living, avoidance of visual symptoms, and disease progression via maintenance of IOP control. We also observed that these patients have varied and nuanced perspectives on surgical management and its outcomes. It behooves providers and trial designers to consider these in future evaluations of new treatments for moderate to severe glaucoma.

To investigate if a stress event can influence intraocular pressure (IOP) in a group of healthy individuals.

Case-control study.

A total of 28 healthy subjects were included 17 in the stress group and 11 in the control group.

The Trier Social Stress Test (TSST) is a tool to evaluate cortisol response to psychologic stimulation based on the stress induced by public speaking. All participants underwent a modified diurnal tension curve (DTC) 1 week before the TSST, with 3 IOP measurements performed between 800 am and 200 pm. We evaluated the response to the TSST measuring the levels of salivary cortisol, IOP, and heart rate before, immediately after, and 40 minutes after TSST. The State Trait Anxiety Inventory (STAI) was applied to evaluate the levels of anxiety at the same time intervals.

Changes in IOP (mmHg), salivary cortisol, heart rate, and STAI scores.

At baseline, there were no significant differences between case and controls regarding age (52.2 ± 6.26 vs. 53.8 ± 8.4 years, P= 0.661), genderIOP, salivary cortisol, STAI scores, and heart rate occurred after inducing psychologic stress with TSST in a group of healthy individuals.

A phase 3 trial (MERCURY-1) investigated efficacy and safety of a once-daily, fixed-dose combination (FDC) of netarsudil and latanoprost, compared with each active component, in reducing elevated intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). A planned 3-month analysis demonstrated the superiority of netarsudil/latanoprost FDC over its individual active components at every assessment. Herein, the 12-month efficacy and safety of netarsudil/latanoprost FDC are reported.

Double-masked, randomized, active-controlled, parallel-group trial.

Patients had unmedicated IOP >20 to <36 mmHg in both eyes at 800 am and met other standard criteria for OAG or OHT.

Randomization to once-daily netarsudil 0.02%/latanoprost 0.005% FDC (n= 238), netarsudil 0.02% only (n= 243), or latanoprost 0.005% only (n= 237). Patients instilled study drug into each eye between 800 pm and 1000 pm.

IOP was obtained at 800 am, 1000 am, and 400 pm on day 1 (baseline); at weeks 2st group.

Results at 12 months revealed superior efficacy for netarsudil/latanoprost FDC compared with the individual components, netarsudil and latanoprost, at every time point assessed and an ocular tolerability profile similar to that of netarsudil alone.

Results at 12 months revealed superior efficacy for netarsudil/latanoprost FDC compared with the individual components, netarsudil and latanoprost, at every time point assessed and an ocular tolerability profile similar to that of netarsudil alone.

Biliary stones are the most common etiology of acute pancreatitis Cholecystectomy has been accepted as a popular treatment for acute biliary pancreatitis (ABP) to reduce the risk of recurrent complications. However, the precise time of intervention still remains controversial.

The aim of this meta-analysis was to compare early and delayed cholecystectomy and determine the most precise timing of cholecystectomy following gallstone pancreatitis.

Search the publications on comparison the efficacy of early cholecystectomy comparison with delayed cholecystectomy in treatment outcomes of ABP to October, 2018. After rigorous reviewing on quality, the data was extracted from eligible trials. All trials analyzed the summary hazard ratios (HRs) of the endpoints of interest, including survival data and individual postoperative complications.

A total of 9 trials were met our inclusion criteria. The pooled results indicate that postoperative complications、readmission rate、conversion to an open procedure and cholecystectomy-related morbidity/mortality did not have statistical significance (P>0.05) between the early and delayed cholecystectomy. While, the length of hospital stay was shorter for the early cholecystectomy group than the delayed group in all included studies.

Although the efficacy of delayed intervention in terms of inflammation reduction is definite, their adverse events are often major limitations. In the present study, an early cholecystectomy may result in a significantly shortened hospital stays without increased complications or mortality.

Although the efficacy of delayed intervention in terms of inflammation reduction is definite, their adverse events are often major limitations. In the present study, an early cholecystectomy may result in a significantly shortened hospital stays without increased complications or mortality.

Current information-processing models of sexual arousal imply that both controlled and automatic affective-motivational processes are critically involved in sexual responding and suggest that dysfunctional automatic processes may be involved in the development and persistence of sexual dysfunctions. Because (dysfunctional) automatic processes and responses cannot be adequately captured by common self-report measures, implicit performance-based measures have been developed to index these processes.

This review provides an overview of studies that used implicit tasks in clinical sexual research, and critically evaluates the contribution and promise of these measures to improve our understanding of the mechanisms involved in sexual dysfunctions.

6 electronic main databases (AMED, MEDLINE, PsycArticles, Psychology & Behavioral Sciences Collection, PsycINFO, and SocINDEX) were searched for studies involving implicit measurement techniques to measure automatic processes in clinical sex research.

A serie of psychometrically sound measures are critical for a more comprehensive evaluation of the relevance of implicit measures in clinical sex research and their usefulness as indices of individual differences in clinical practice. Hinzmann J, Borg C, de Jong PJ. Implicit Measures in Clinical Sex Research A Critical Evaluation. Sex Med Rev 2020;8531-541.

Implicit measures showed some promise as tools to index automatic sex-relevant cognitive mechanisms in sexual dysfunctions. Yet, more systematic research and the development of psychometrically sound measures are critical for a more comprehensive evaluation of the relevance of implicit measures in clinical sex research and their usefulness as indices of individual differences in clinical practice. Hinzmann J, Borg C, de Jong PJ. Implicit Measures in Clinical Sex Research A Critical Evaluation. Sex Med Rev 2020;8531-541.

Hemoglobin A1c (HbA1c), a glycated form of hemoglobin, develops when glucose is elevated in the blood. It is used as a marker of how well a diabetic patient has been controlling their blood sugar over the previous 3-4months. Some use HbA1c as a predictor of infection risk during prosthetic surgery, and many surgeons require patients to lower it preoperatively.

This study was designed to comprehensively review the literature relating HbA1c and penile prosthesis (PP).

A PubMed search of English-language articles identified studies that investigate the relationship between HbA1c levels and PP infection. Studies were only included if they reported the mean HbA1c of all PP patients and compared patients who did/did not develop a prosthetic infection. References from relevant articles are included.

A total of 6 studies, 1992-2020, were identified. 2 studies occurred before the advent of antibiotic-enhanced devices in the early 2000s and have limited applicability to the modern era. Of the 4 studies published after, 2 reported a significant difference in mean HbA1c when comparing patients who developed a prosthetic infection and those who did not (9.